阿拉伯糖基胸腺嘧啶 5'-三磷酸酯 | 66097-68-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 中文名称: 阿拉伯糖基胸腺嘧啶 5'-三磷酸酯
• 中文别名: 阿拉伯糖基胸腺嘧啶5'-三磷酸酯
• 英文名称: 5-methyl-1-[O⁵-(tetrahydroxy-[1]triphosphoryl)-β-D-arabinofuranosyl]-1H-pyrimidine-2,4-dione
• 英文别名: 1-β-D-arabinofuranosylthymin-5'-triphosphat；Ara-ttp；[[(2R,3S,4S,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 66097-68-5
• 化学式: C₁₀H₁₇N₂O₁₅P₃
• 分子量: 498.171
• InChiKey: RZCIEJXAILMSQK-JAGXHNFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  259
• 氢给体数：
  7
• 氢受体数：
  15

文献信息

• Process for cognate nucleotide detection in a nucleic acid sequencing workflow
  申请人：Omniome, Inc.

  公开号：US10975427B2

  公开（公告）日：2021-04-13

  Method and composition for identifying cognate nucleotides in a Sequencing By Binding™ procedure, wherein one or more labeled nucleotides are detected in ternary complexes but never incorporated. Labeled nucleotides can be incorporable nucleotides that contact preformed blocked primed template nucleic acids. Alternatively, labeled nucleotides are labeled non-incorporable nucleotides. Labeled nucleotides, including labeled non-incorporable nucleotides, can be detected in ternary complexes in the same reaction mixture that incorporates a reversible terminator nucleotide to create a blocked primed template nucleic acid. Detection of ternary complexes can take place in the presence of a catalytic metal ion.

  在 Sequencing By Binding™ 程序中识别同源核苷酸的方法和组合物，其中在三元复合物中检测到一种或多种标记核苷酸，但从未与之结合。标记的核苷酸可以是可结合的核苷酸，与预先形成的阻断引物模板核酸接触。或者，标记的核苷酸是标记的不可结合核苷酸。标记的核苷酸，包括标记的不可结合核苷酸，可以在同一反应混合物中的三元复合物中检测到，该反应混合物结合了可逆的终止子核苷酸，生成了阻断引物的模板核酸。三元复合物的检测可在催化金属离子存在的情况下进行。
• NUCLEIC ACID SEQUENCING METHODS, KITS AND REAGENTS
  申请人：GeneForm Technologies Limited

  公开号：EP1594987B1

  公开（公告）日：2009-05-27
• Nucleic acid sequencing methods, kits and reagents
  申请人：Hoser J. Mark

  公开号：US20070148645A1

  公开（公告）日：2007-06-28

  The present invention relates to nucleic acid sequencing methods, kits and reagents, and more particularly to methods of sequencing nucleic acid which employ a nucleic acid processing enzyme and one or more nucleotide analogues that are capable of binding to the active site of the enzyme and to complementary bases in the nucleic acid molecule being sequenced, but which are non-incorporable or inhibitors of the nucleic acid processing enzyme. In further aspects, the present invention relates to conjugates which comprise a deoxyribonucleotide triphosphates (DNTPs) or an analogue thereof linked to an intercalating dye.
• PROCESS FOR COGNATE NUCLEOTIDE DETECTION IN A NUCLEIC ACID SEQUENCING WORKFLOW
  申请人：Omniome, Inc.

  公开号：US20180208983A1

  公开（公告）日：2018-07-26

  Method and composition for identifying cognate nucleotides in a Sequencing By Binding™ procedure, wherein one or more labeled nucleotides are detected in ternary complexes but never incorporated. Labeled nucleotides can be incorporable nucleotides that contact preformed blocked primed template nucleic acids. Alternatively, labeled nucleotides are labeled non-incorporable nucleotides. Labeled nucleotides, including labeled non-incorporable nucleotides, can be detected in ternary complexes in the same reaction mixture that incorporates a reversible terminator nucleotide to create a blocked primed template nucleic acid. Detection of ternary complexes can take place in the presence of a catalytic metal ion.
• US8399196B2
  申请人：——

  公开号：US8399196B2

  公开（公告）日：2013-03-19