1-碘-2-丙氧基-乙烷 | 149230-00-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-碘-2-丙氧基-乙烷
• 英文名称: 1-iodo-2-propoxy-ethane
• 英文别名: (β-Jod-aethyl)-propyl-aether；1-Jod-2-propoxy-aethan；1-(2-iodoethoxy)propane
• CAS: 149230-00-2
• 化学式: C₅H₁₁IO
• 分子量: 214.046
• InChiKey: DSCSVCWUUUKJDV-UHFFFAOYSA-N

物化性质

• 沸点：
  175-175.3 °C
• 密度：
  1.5379 g/cm3(Temp: 15 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  7
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-碘-2-丙氧基-乙烷 、 三甲胺 在 乙醇 作用下， 生成 trimethyl-(2-propoxy-ethyl)-ammonium; iodide
  参考文献：
  名称：

  Ewins, Biochemical Journal, 1914, vol. 8, p. 370

  摘要：

  DOI：
• 作为产物：
  描述：

  丙醇 、 1,2-二碘乙烷 生成 1-碘-2-丙氧基-乙烷
  参考文献：
  名称：

  THE EFFECT OF PROFILING DIALYSATE SODIUM AND ULTRAFILTRATION ON PATIENT COMFORT AND CARDIOVASCULAR STABILITY DURING HAEMODIALYSIS

  摘要：

  SUMMARYThe aim of this study was to investigate what affect profiling dialysate sodium and ultrafiltration rate had on cardiovascular stability during haemodialysis, and if there was any effect on patients' fluid balance, thirst, serum sodium levels, blood pressure, or comfort and tolerance.The past decade has seen major advances in haemodialysis machine technology. Parallel developments have included profiling dialysate sodium levels and fluid removal during dialysis. However, some dialysis centres do not use profiling due to fears of long‐term detrimental effects, especially with regard to hypertension and fluid control. Within my own workplace, approximately 30% of haemodialysis treatments utilise either sodium or ultrafiltration profiling, or a combination of both. Anecdotally, we have seen an increase in cardiovascular stability and haemodialysis tolerance. The aim of this study was to identify the effects of profiling haemodialysis, to ensure that the treatment we offer patients is safe and effective.

  DOI：

  10.1111/j.1755-6686.2003.tb00276.x

文献信息

• 4-Arylpiperidine derivatives for the treatment of pruritus
  申请人：Pfizer Inc.

  公开号：US06518282B1

  公开（公告）日：2003-02-11

  There is provided a compound of formula I, wherein R1, R2, R3 and R4 have meanings given in the description, which are useful in the prophylaxis and in the treatment of pruritus.

  提供了一种具有化学式I的化合物，其中R1、R2、R3和R4的含义如描述中所示，在预防和治疗瘙痒方面具有用处。
• SMITH, KIM R.;BORLAND, JAMES E.;SAUER, JOE D.
  作者：SMITH, KIM R.、BORLAND, JAMES E.、SAUER, JOE D.

  DOI：——

  日期：——
• Ewins, Biochemical Journal, 1914, vol. 8, p. 370
  作者：Ewins

  DOI：——

  日期：——
• THE EFFECT OF PROFILING DIALYSATE SODIUM AND ULTRAFILTRATION ON PATIENT COMFORT AND CARDIOVASCULAR STABILITY DURING HAEMODIALYSIS
  作者：M. Gerrish、J. Little

  DOI：10.1111/j.1755-6686.2003.tb00276.x

  日期：2003.4.6

  SUMMARYThe aim of this study was to investigate what affect profiling dialysate sodium and ultrafiltration rate had on cardiovascular stability during haemodialysis, and if there was any effect on patients' fluid balance, thirst, serum sodium levels, blood pressure, or comfort and tolerance.The past decade has seen major advances in haemodialysis machine technology. Parallel developments have included profiling dialysate sodium levels and fluid removal during dialysis. However, some dialysis centres do not use profiling due to fears of long‐term detrimental effects, especially with regard to hypertension and fluid control. Within my own workplace, approximately 30% of haemodialysis treatments utilise either sodium or ultrafiltration profiling, or a combination of both. Anecdotally, we have seen an increase in cardiovascular stability and haemodialysis tolerance. The aim of this study was to identify the effects of profiling haemodialysis, to ensure that the treatment we offer patients is safe and effective.