The present invention relates to a sodium salt represented by average formula (I):
(wherein, m
1
, n
1
, m
2
and n
2
respectively and independently represent a positive number of
0
0r
2
or less, provided that m
1
+n
1
=2, m
2
+n
2
=2, 0
本发明涉及一种由平均式(I)表示的钠盐：（其中，m1、n1、m2和n2分别独立地表示00r2或更小的正数，前提是m1+n1=2，m2+n2=2，0
Left-Side Glucose Lipid a Analogue
申请人：Shiozaki Masao
公开号：US20090062214A1
公开（公告）日：2009-03-05
A compound having excellent macrophage activity inhibitory action, which is represented by the general following formula:
wherein Q represents an oxygen atom, a C
1
-C
3
alkylene group, a —O-Alk- group or a —O-Alk-O— group (in which Alk is a C
1
-C
3
alkylene group),
R
1
represents a C
1
-C
20
alkanoyl group which may be substituted, a C
3
-C
20
alkenoyl group which may be substituted or a C
3
-C
20
alkynoyl group which may be substituted,
R
2
, R
3
and R
4
, which may be the same or different, represent a hydrogen atom, a C
1
-C
20
alkyl group which may be substituted, a C
2
-C
20
alkenyl group which may be substituted, a C
2
-C
20
alkynyl group which may be substituted, a C
1
-C
20
alkanoyl group which may be substituted, a C
3
-C
20
alkenoyl group which may be substituted or a C
3
-C
20
alkynoyl group which may be substituted,
R
5
represents a hydrogen atom, a halogen atom, a hydroxyl group, a C
1
-C
6
alkoxy group which may be substituted, a C
2
-C
6
alkenyloxy group which may be substituted or a C
2
-C
6
alkynyloxy group which may be substituted, and
W represents an oxygen atom or a —NH— group, or a pharmacologically acceptable salt thereof.
一种具有出色的巨噬细胞活性抑制作用的化合物，其通式如下：其中，Q代表氧原子、C1-C3烷基、—O-Alk-基团或—O-Alk-O—基团（其中，Alk代表C1-C3烷基），R1代表C1-C20烷酰基，可以被取代的C3-C20烯酰基或可以被取代的C3-C20炔酰基，R2、R3和R4，可以相同也可以不同，代表氢原子、可以被取代的C1-C20烷基、可以被取代的C2-C20烯基、可以被取代的C2-C20炔基、可以被取代的C1-C20烷酰基、可以被取代的C3-C20烯酰基或可以被取代的C3-C20炔酰基，R5代表氢原子、卤原子、羟基、可以被取代的C1-C6烷氧基、可以被取代的C2-C6烯氧基或可以被取代的C2-C6炔氧基，W代表氧原子或—NH—基团，或其药学上可接受的盐。
[EN] REAGENTS AND METHODS FOR PREPARING LPS ANTAGONIST B1287 AND STEREOISOMERS THEREOF<br/>[FR] REACTIFS ET PROCEDES DE PREPARATION D'UN ANTAGONISTE LPS B1287 ET DE STEREOISOMERES DE CELUI-CI
申请人：EISAI CO LTD
公开号：WO2004074303A3
公开（公告）日：2004-12-29
Substituted Liposaccharides Useful in the Treatment and Prevention of Endotoxemia
申请人：Christ William J.
公开号：US20080214802A1
公开（公告）日：2008-09-04
Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.
PROCESS FOR PRODUCTION OF LIPID A ANALOGUE
申请人：Tagami Katsuya
公开号：US20090149647A1
公开（公告）日：2009-06-11
Discloses is a process for producing α-D-glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]- or 1-(dihydrogen phosphate) tetrasodium salt which is useful as an active ingredient of a pharmaceutical or an intermediate for the synthesis thereof, which is environment-friendly and excellent in safety, operationality and reproducibility. A process for producing a compound represented by the formula (I) comprising the steps of reacting a compound represented by the formula (VIII) with a palladium catalyst in the presence of a nucleopholic agent and treating the product with a sodium source.
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