10,12-二十五二炔酰胺 | 178323-65-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 10,12-二十五二炔酰胺
• 英文名称: 10,12-pentacosadiynoyl amide
• 英文别名: 10,12-Pentacosadiynamide；pentacosa-10,12-diynamide
• CAS: 178323-65-4
• 化学式: C₂₅H₄₃NO
• 分子量: 373.623
• InChiKey: MSWYELBSLSBHBS-UHFFFAOYSA-N

物化性质

• 熔点：
  99-102 °C(Solv: chloroform (67-66-3))
• 沸点：
  548.7±33.0 °C(Predicted)
• 密度：
  0.914±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  10,12-二十五二炔酰胺 在 红铝 作用下， 以 甲苯 为溶剂， 反应 17.0h， 以72%的产率得到1-amino-10,12-pentacosadiyne
  参考文献：
  名称：

  Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

  摘要：

  The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T-10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T-10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.047
• 作为产物：
  描述：

  10,12-二十五碳二炔酸 在 ammonium hydroxide 、 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 10,12-二十五二炔酰胺
  参考文献：
  名称：

  Lipophilic peptide nucleic acids containing a 1,3-diyne function: synthesis, characterization and production of derived polydiacetylene liposomes

  摘要：

  Adenine-, cytosine- and thymine-containing peptide nucleic acid (PNA) monomers have been synthesized in which either diacetylenic or stearoyl moieties are attached to the N-or C-terminus; the diacetylenic group is embedded within a long hydrocarbon chain. A range of analogous lipophilic functionalized PNA oligomers have been prepared using either solid phase synthesis or a post-synthetic solution phase procedure following cleavage of the PNA oligomer from the solid Support. Selected functionalized PNA monomers and oligomers have been incorporated into liposomal polydiacetylenes and characterized by UV-vis absorption spectroscopy. Preliminary investigations show that blue PDA-liposomes containing thymine-based PNAs can be formed and that production of liposomes with other PNA systems are viable. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.07.021

文献信息

• Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid
  作者：Nicola M Howarth、W.Edward Lindsell、Euan Murray、Peter N Preston

  DOI：10.1016/j.tetlet.2003.09.047

  日期：2003.10

  The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T-10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T-10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. (C) 2003 Elsevier Ltd. All rights reserved.
• TARGETED POLYMERIZED NANOPARTICLES FOR CANCER TREATMENT
  申请人：Children's Hospital Los Angeles

  公开号：EP3129062A2

  公开（公告）日：2017-02-15
• DURATION AND ENVIRONMENTAL MONITORING COMPOSITIONS, DEVICES METHODS FOR PREPARATION AND SYSTEMS
  申请人：Ribi Hans O.

  公开号：US20100029004A1

  公开（公告）日：2010-02-04

  Duration monitoring co-topo-polymeric compositions and methods for making and using the same are provided. Indicator compositions of the invention include an organic polymer and undergo a color change, which may be reversible or irreversible, in a time dependent manner following an initiation event. Also provided are indicator devices that include the indicator compositions of the invention. The compositions of the invention find use in a variety of different applications.
• Type Separation of Single-Walled Carbon Nanotubes via Two-Phase Liquid Extraction
  申请人：Ziegler Kirk Jeremy

  公开号：US20100166637A1

  公开（公告）日：2010-07-01

  The subject invention provides a two-phase liquid-liquid extraction process that enables sorting and separation of single-walled carbon nanotubes based on (n, m) type and/or diameter. The two-phase liquid extraction method of the invention is based upon the selective reaction of certain types of nanotubes with electron withdrawing functional groups as well as the interaction between a phase transfer agent and ionic moieties on the functionalized nanotubes when combined in a two-phase liquid solution. Preferably, the subject invention enables efficient, bulk separation of metallic/semi-metallic nanotubes from semi-conducting nanotubes. More preferably, the subject invention enables efficient, bulk separation of specific (n, m) types of nanotubes.
• BIOMARKER DETECTION-2
  申请人：Nagy Jon Owen

  公开号：US20110166043A1

  公开（公告）日：2011-07-07

  Provided are methods, compositions and articles of manufacture for detecting biomarkers indicative of exposure of a mammal to organophosphate compounds. The organophosphate compound includes pesticides, their metabolites and highly reactive organophosphoryl compounds. In one aspect of the invention, the biomarker results from interaction of the organophosphate compound with a polypeptide such as a serine hydrolase that includes acetylcholiestersae. The interaction of a biomarker so derived with a optical sensor comprising a receptor bound to a biopolymer results in an optical readout that reports the presence of the biomarker. In one aspect of the invention the receptor that is bound to a biopolymer, such as a poly-di-acetylene polymer, is a antibody that selectively recognizes the biomarker.