10-[2-(二甲基氨基)丙基]吩噻嗪马来酸盐 | 5992-13-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 10-[2-(二甲基氨基)丙基]吩噻嗪马来酸盐
• 英文名称: promethazine maleate
• 英文别名: [10-[2-(Dimethylammonio)propyl]-10H-phenothiazinium]maleate；(Z)-but-2-enedioate;dimethyl-[1-(10H-phenothiazin-10-ium-10-yl)propan-2-yl]azanium
• CAS: 5992-13-2
• 化学式: C₄H₄O₄*C₁₇H₂₀N₂S
• 分子量: 400.499
• InChiKey: JSYGKADGBBTFIQ-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NASAL SPRAY COMPOSITION AND METHOD FOR TREATING RHINITIS, SINUSITIS OR BOTH
  申请人：Knauer Kent A.

  公开号：US20100099650A1

  公开（公告）日：2010-04-22

  A nasal spray composition for treating mucosal inflammation associated with rhinitis, sinusitis, or both can include a decongestant and at least one therapeutic agent. The therapeutic agent is selected from the group consisting of an anti-inflammatory agent and an anti-histamine agent. The nasal spray composition is non-habituating and is administered intranasally to a subject in need thereof.
• AQUEOUS NASAL SPRAY COMPOSITION OF CORTICOSTEROIDS
  申请人：Gavis Pharmaceuticals

  公开号：US20160220584A1

  公开（公告）日：2016-08-04

  A novel and improved aqueous nasal spray composition of corticosteroids is provided. The composition is characterized by containing either chitosan or polycarbophil as the bioadhesive or mucoadhesive agent. The invention also provides a method of alleviating or treating corticosteroid responsive conditions or disease by topically administering said aqueous nasal spray composition of corticosteroid to the nasal cavity.
• AQUEOUS NASAL SPRAY COMPOSITION OF CORTICOSTEROIDS AND ANTIHISTAMINIC AGENTS
  申请人：Gavis Pharmaceuticals

  公开号：US20160220583A1

  公开（公告）日：2016-08-04

  A novel and improved aqueous nasal spray composition comprising a combination of corticosteroids and antihistaminic agents is provided. The composition is characterized by containing chitosan and/or polycarbophil as a bio-adhesive or mucoadhesive agent. The invention also provides a method of alleviating or treating a corticosteroid or antihistaminic agent responsive condition or disease by topically administering said aqueous nasal spray composition to the nasal cavity.
• US5948414A
  申请人：——

  公开号：US5948414A

  公开（公告）日：1999-09-07
• [EN] NASAL SPRAY COMPOSITION AND METHOD FOR TREATING RHINITIS, SINUSITIS OR BOTH<br/>[FR] COMPOSITION DE PULVÉRISATION NASALE ET PROCÉDÉ POUR TRAITER UNE RHINITE, UNE SINUSITE OU LES DEUX
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2008070264A2

  公开（公告）日：2008-06-12

  [EN] A nasal spray composition for treating mucosal inflammation associated with rhinitis, sinusitis, or both can include a decongestant and at least one therapeutic agent. The therapeutic agent is selected from the group consisting of an anti-inflammatory agent and an anti-histamine agent. The nasal spray composition is non-habituating and is administered intranasally to a subject in need thereof.
  [FR] L'invention concerne une composition de pulvérisation nasale pour traiter une inflammation des muqueuses associée à une rhinite, une sinusite ou aux deux, qui peut comprendre un décongestionnant et au moins un agent thérapeutique. L'agent thérapeutique est choisi dans le groupe consistant en un agent anti-inflammatoire et un agent anti-histaminique. La composition de la pulvérisation nasale n'est pas toxicomanogène et est administrée par voie intra-nasale à un sujet qui en a besoin.