10-甲基-10-十八醇 | 50997-06-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 10-甲基-10-十八醇
• 英文名称: 10-methyl-10-nonadecanol
• 英文别名: 10-methylnonadecan-10-ol
• CAS: 50997-06-3
• 化学式: C₂₀H₄₂O
• 分子量: 298.553
• InChiKey: BTFNSSWQSTYKHB-UHFFFAOYSA-N

物化性质

• 沸点：
  349.5±10.0 °C(Predicted)
• 密度：
  0.838±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙酸烯丙酯 、 Magnesium, chlorononyl- 在 iron(II) acetate 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以52%的产率得到10-甲基-10-十八醇
  参考文献：
  名称：

  作为掩蔽烷基-烷基交叉偶联的铁催化烯丙基化-氢化序列†

  摘要：

  在温和条件下（Fe(OAc) 2或 Fe(acac) 2 , Et 2 O, rt），有机镁试剂（烷基、芳基）与简单的乙酸烯丙酯发生铁催化烯丙基化反应，得到各种烯烃和苯乙烯衍生物。机理研究表明了同伦催化剂的运作。这种铁催化烯丙基化与铁催化氢化的顺序组合导致整体C(sp 3 )–C(sp 3 )-键形成，这构成了具有挑战性的与烷基卤化物的直接交叉偶联方案的有吸引力的替代方案。

  DOI：

  10.1039/c9ra07604b

文献信息

• COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
  申请人：ModernaTX, Inc.

  公开号：US20220409536A1

  公开（公告）日：2022-12-29

  The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

  该披露涉及新型脂质和相关组合物。纳米粒子组合物包括一种新型脂质以及其他脂质，例如磷脂、结构脂质和PEG脂质。纳米粒子组合物进一步包括治疗和/或预防剂，例如RNA，可用于将治疗和/或预防剂传递到哺乳动物细胞或器官中，例如调节多肽、蛋白质或基因表达。
• Compounds and compositions for intracellular delivery of therapeutic agents
  申请人：ModernaTX, Inc.

  公开号：US10266485B2

  公开（公告）日：2019-04-23

  The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

  本公开的特征是新型脂质和涉及新型脂质的组合物。纳米颗粒组合物包括新型脂质以及磷脂、结构脂质和 PEG 脂质等其他脂质。纳米颗粒组合物进一步包括治疗和/或预防剂，如 RNA，可用于向哺乳动物细胞或器官输送治疗和/或预防剂，以调节多肽、蛋白质或基因表达等。
• COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS TO IMMUNE CELLS
  申请人：ModernaTX, Inc.

  公开号：US20190314291A1

  公开（公告）日：2019-10-17

  The disclosure features immune cell delivery lipid nanoparticle (LNP) compositions that allow for enhanced delivery of agents, e.g., nucleic acids, such as therapeutic and/or prophylactic RNAs, to immune cells, in particular T cells, as well as B cells, dendritic cells and monocytes. The LNPs comprise an effective amount of an immune cell delivery potentiating lipid such that delivery of an agent by an immune cell delivery LNP is enhanced as compared to an LNP lacking the immune cell delivery potentiating agent. Methods of using the immune cell delivery LNPs for delivery of agents, e.g., nucleic acid delivery, for protein expression, for modulating immune cell activity and modulating immune responses are also disclosed.
• LIPID NANOPARTICLE FORMULATION
  申请人：ModernaTX, Inc.

  公开号：US20200129445A1

  公开（公告）日：2020-04-30

  The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
• US9868692B2
  申请人：——

  公开号：US9868692B2

  公开（公告）日：2018-01-16