11-[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]十一碳-1-烯 | 219641-34-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 11-[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]十一碳-1-烯
• 英文名称: 11-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)undec-1-ene
• 英文别名: 2,5,8,11-tetraoxadocos-21-ene；11-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]undec-1-ene
• CAS: 219641-34-6
• 化学式: C₁₈H₃₆O₄
• 分子量: 316.481
• InChiKey: FGUIEJPCDOYEBG-UHFFFAOYSA-N

物化性质

• 沸点：
  380.9±22.0 °C(Predicted)
• 密度：
  0.914±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  11-[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]十一碳-1-烯 在 盐酸 、 偶氮二异丁腈 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 11-[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]十一烷-1-硫醇
  参考文献：
  名称：

  Probing Resistance to Protein Adsorption of Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers by Scanning Force Microscopy

  摘要：

  Functionalized scanning force microscope (SFM) probes were used to investigate and to mimic the interaction between fibrinogen and self-assembled monolayers (SAMs) of methoxytri(ethylene glycol) undecanethiolates -S(CH2)(11)(OCH2CH2)(3)OCH3 (EG(3)-OMe) on gold and silver surfaces. The SAMs on gold an resistant to protein adsorption, whereas the films on silver adsorb variable amounts of fibrinogen. Experiments were performed with both charged and hydrophobic tips as models for local protein structures to determine the influence of these parameters on the interaction with the SAMs. A striking difference between the two monolayers was established when the forces were measured in an aqueous environment with hydrophobic probes. While a long-range attractive hydrophobic interaction was observed for the EG3-OMe on silver, a repulsive force was measured for EG3-OMe on gold. The strong dependence of the repulsive force for the EG3-OMe-gold system upon the solution ionic strength suggests that this interaction has a significant electrostatic contribution. The observed differences are attributed to the distinct molecular :conformations of the oligo(ethylene glycol) tails on the gold-supported (helical) and silver-supported ("all-trans") monolayers. A comparison of the force/distance curves for the EG3-OMe SAMs with those measured under identical conditions on end-grafted poly(ethylene glycol) (PEG 2000) on gold further emphasizes that the nature of the repulsive forces originating from the short-chain oligomers is unique and not related to a "steric repulsion" effect.

  DOI：

  10.1021/ja991049b
• 作为产物：
  描述：

  三甘醇单甲醚 、 11-溴-1-十一烯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以73%的产率得到11-[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]十一碳-1-烯
  参考文献：
  名称：

  Evidence for Why Tri(ethylene oxide) Functionalized Si-C Linked Monolayers on Si(111) Have Inferior Protein Antifouling Properties Relative to the Equivalent Alkanethiol Monolayers Assembled on Gold

  摘要：

  通过热水解反应，在 Si(111)-H 表面形成了含有三（环氧乙烷）分子的高质量甲氧基端单层。X 射线光电子能谱、接触角和 X 射线反射率测量结果表明，这些 Si-C 连接单层的蛋白质防污性能不理想的原因是链的横向堆积密度降低，从而形成了内外亲水性不足的无序层。

  DOI：

  10.1071/ch05121

文献信息

• Sample presentation device
  申请人：Belisle M. Christopher

  公开号：US20050164402A1

  公开（公告）日：2005-07-28

  The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

  本发明涉及用于执行分析测量的样品呈现装置。这些装置已被配置为使液体处理的各个方面得到了促进，例如：保留、储存、运输、浓缩、定位和转移。此外，这些装置可以增强分析物的检测和表征。本发明的样品呈现装置由一个或多个基板组成，具有多个不同润湿性的区域。公开了使用本发明的样品呈现装置分析样品的方法，以及制备样品呈现装置的方法。
• Sample Presentation Device
  申请人：Belisle Christopher M.

  公开号：US20080248589A1

  公开（公告）日：2008-10-09

  The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

  本发明涉及用于执行分析测量的样品呈现装置。这些装置已被配置为使液体处理的各个方面如：保留、储存、运输、浓缩、定位和转移成为可能。此外，这些装置可以增强分析物的检测和表征。本发明的样品呈现装置包括一个或多个基板，其具有多个不同润湿性的区域。揭示了使用本发明的样品呈现装置分析样品的方法，以及制作样品呈现装置的方法。
• SAMPLE PRESENTATION DEVICE
  申请人：Belisle Christopher M.

  公开号：US20110070659A1

  公开（公告）日：2011-03-24

  The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

  本发明涉及用于执行分析测量的样品呈现装置。这些装置已被配置为使得液体处理的各个方面如保留、存储、传输、浓缩、定位和转移成为可能。此外，这些装置可以增强分析物的检测和表征。本发明的样品呈现装置由一个或多个基板组成，具有多个不同润湿性的区域。公开了使用本发明的样品呈现装置分析样品的方法，以及制造样品呈现装置的方法。
• Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules
  申请人：INTERUNIVERSITAIR MICROELEKTRONICA CENTRUM ( IMEC)

  公开号：EP1607743A1

  公开（公告）日：2005-12-21

  The present invention provides a silane molecule which combines preactivated and protein-resistant functionalities in one molecule, the molecule has a general formula:         A-(CH2)n-(O[CH2]t)m-(CH2)v-Y     (1) wherein A is a functional group for binding to a substrate and Y is a functional group for binding to biomolecules. The invention furthermore provides a method for the synthesis of such a silane molecule and a method for depositing a monolayer of such silane molecules onto a substrate. Such a monolayer of silane molecules may be used in biosensors, DNA/protein micro-arrays or other sensor applications. For further lowering the protein binding to the surface of the biosensor, the monolayer may furthermore comprise second silane molecules with formula:         B-(CH2)o-(OCH2CH2)r-Z     (4)

  本发明提供了一种硅烷分子，它在一个分子中结合了预活化官能团和抗蛋白质官能团，该分子具有通式： A-(CH2)n-(O[ ]t)m-( )v-Y (1) 其中 A 是与底物结合的官能团，Y 是与生物大分子结合的官能团。 本发明还提供了合成这种硅烷分子的方法和将这种硅烷分子的单层沉积到基底上的方法。这种硅烷分子单层可用于生物传感器、DNA/蛋白质微阵列或其他传感器应用。为了进一步降低蛋白质与生物传感器表面的结合力，单层硅烷分子还可进一步包含式如下的第二硅烷分子： B-( )o-(O )r-Z (4)
• Nanoparticle-Based Receptors Mimic Protein-Ligand Recognition
  作者：Laura Riccardi、Luca Gabrielli、Xiaohuan Sun、Federico De Biasi、Federico Rastrelli、Fabrizio Mancin、Marco De Vivo

  DOI：10.1016/j.chempr.2017.05.016

  日期：2017.7

  The self-assembly of a monolayer of ligands on the surface of noble-metal nanoparticles dictates the fundamental nanoparticle's behavior and its functionality. In this combined computational-experimental study, we analyze the structure, organization, and dynamics of functionalized coating thiols in monolayer-protected gold nanoparticles (AuNPs). We explain how functionalized coating thiols self-organize through a delicate and somehow counterintuitive balance of interactions within the monolayer itself and with the solvent. We further describe how the nature and plasticity of these interactions modulate nanoparticle-based chemosensing. Importantly, we found that self-organization of coating thiols can induce the formation of binding pockets in AuNPs. These transient cavities can accommodate small molecules, mimicking protein-ligand recognition, which could explain the selectivity and sensitivity observed for different organic analytes in NMR chemosensing experiments. Thus, our findings advocate for the rational design of tailored coating groups to form specific recognition binding sites on monolayer-protected AuNPs.