1H,1H,2H,2H-全氟-7-甲基辛-1-醇 | 20015-46-7

• 物质功能分类: 生物 - 细胞培养 - 培养基
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1H,1H,2H,2H-全氟-7-甲基辛-1-醇
• 中文别名: 1H,1H,2H,2H-全氟-7-甲基-1-辛醇
• 英文名称: 1H,1H,2H,2H-perfluoro-7-methyloctan-1-ol
• 英文别名: 3,3,4,4,5,5,6,6,7,8,8,8-Dodecafluoro-7-(trifluoromethyl)octan-1-ol
• CAS: 20015-46-7
• 化学式: C₉H₅F₁₅O
• 分子量: 414.114
• InChiKey: WVZPXINSJOBSTI-UHFFFAOYSA-N

物化性质

• 沸点：
  98 °C
• 密度：
  1,754 g/cm3
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  16

安全信息

• 危险等级：
  FLAMMABLE
• 危险品标志：
  F
• 危险类别码：
  R36/37/38
• 安全说明：
  S26,S36

反应信息

• 作为反应物：
  描述：

  1H,1H,2H,2H-全氟-7-甲基辛-1-醇 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 34.0h， 生成 tert-butyl (4-(2-(diphenoxyphosphoryl)-2-((((3,3,4,4,5,5,6,6,7,8,8,8-dodecafluoro-7-(trifluoromethyl)octyl)oxy)carbonyl)amino)ethyl)phenyl)carbamate
  参考文献：
  名称：

  α-氨基二苯基膦酸酯是大肠杆菌ClpP蛋白酶的新型抑制剂

  摘要：

  革兰氏阴性细菌对抗生素的耐药性日益成为全球性问题，因此需要具有新颖作用机制的新型抗生素。酪蛋白水解蛋白酶亚基P（ClpP）是一种在细菌中保守的丝氨酸蛋白酶，被认为是一种有趣的药物靶标。ClpP功能与蛋白质代谢和体内稳态，应激反应以及其他过程中的毒力有关。这项研究的重点是确定大肠杆菌ClpP的新抑制剂并了解其作用方式。测试了基于二芳基膦酸酯战斗部的丝氨酸蛋白酶抑制剂的重点文库对ClpP的抑制作用，并对命中化合物进行了化学探索。总共有14种新的强效大肠杆菌抑制剂确定了ClpP。化合物85和92分别由于其效力以及适度但一致的抗菌特性以及有利的细胞毒性特性而成为本研究中最令人感兴趣的化合物。

  DOI：

  10.1021/acs.jmedchem.8b01466

文献信息

• POLYCARBONATE-BASE POLYMER, PRODUCTION PROCESS, RESIN COATING FLUID PREPARED THEREFROM, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR PREPARED THEREFROM
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0837085A1

  公开（公告）日：1998-04-22

  A polymer comprising mainly repeating units (1) and/or repeating units (2), containing optionally terminal groups (3) and/or repeating units (4), and having a reduced viscosity [ηsp/c] of 0.2 to 10.0 dl/g as measured in a 0.5 g/dl solution thereof in methylene chloride at 20°C; a resin coating fluid containing the polymer, a charge-transfer substance and a solvent; and an electrophotographic photoreceptor containing the polymer as a binder resin in a photosensitive layer, wherein Rf1 represents a group that is composed of at least carbon atoms and fluorine atoms and bonded directly to the two oxygen atoms of the carbonate linkage in the general formula (1) without any intervening arylene group; and Rf2 represents a group that is composed of at least carbon atoms and fluorine atoms and bonded directly to one of the oxygen atoms of the carbonate linkage in the general formula (3) without any intervening arylene group.

  一种主要由重复单元（1）和/或重复单元（2）组成的聚合物，含有任选的末端基团（3）和/或重复单元（4），在 0.其中 Rf1 代表至少由碳原子和氟原子组成并直接与通式（1）中碳酸酯连接的两个氧原子键合的基团，而没有任何芳基介入；Rf2 代表一个至少由碳原子和氟原子组成的基团，直接与通式（3）中碳酸酯链节的一个氧原子键合，中间不含任何芳烯基。
• Fluorine-modified polyurethane resins containing one or two constituents, method for the production thereof, and use of the same
  申请人：Maier Alois

  公开号：US20060167206A1

  公开（公告）日：2006-07-27

  A description is given of a fluorine-modified one- or two-component polyurethane resin having improved surface properties, which is obtainable by a) preparing a fluorine-modified polyurethane prepolymer having free isocyanate groups or free amino and/or hydroxyl groups, or a fluorine-modified polyol mixture having free hydroxyl groups (binder), and by b) preparing a fluorine-modified polyurethane resin having a polymer-bonded fluorine content of 1% to 4% by weight in the system as a whole by reacting the fluorine-modified polyurethane prepolymer from stage a 3 ) in the case of a one-component application with atmospheric moisture, or reacting the fluorine-modified polyurethane prepolymer or polyol mixture (binder) in the case of a two-component application with a crosslinker component (D) (curing agent), with a formulating component (F)(ii) in the presence if desired of a solvent component (L)(iii) and also of a catalyst. Through the use of suitable fluorinated macromonomers in the one- or two-component polyurethane resins of the invention it is possible to produce hard coating systems and/or surfaces having very low surface tensions and very high contact angles. Furthermore, the dirt pickup tendency of these polyurethane resins is also significantly reduced as compared with the known prior art.

  描述了一种表面性能得到改善的氟改性单组分或双组分聚氨酯树脂，其制备方法是 a) 制备具有游离异氰酸酯基团或游离氨基和/或羟基的氟改性聚氨酯预聚物、或具有游离羟基的氟改性多元醇混合物（粘结剂），并通过以下方法制备氟改性聚氨酯树脂： b) 将阶段 a 的氟改性聚氨酯预聚物与阶段 b 的氟改性聚氨酯预聚物反应，制备整个体系中聚合物键合氟含量为 1%至 4%（重量百分比）的氟改性聚氨酯树脂。 3 在单组分应用中，将氟改性聚氨酯预聚物或多元醇混合物（粘合剂）与交联剂组分 （D）（固化剂）和配方组分（F）(ii)反应；在双组分应用中，将氟改性聚氨酯预聚 物或多元醇混合物（粘合剂）与溶剂组分（L）(iii)和催化剂反应。通过在本发明的单组分或双组分聚氨酯树脂中使用合适的含氟大单体，可以生产出具有极低表面张力和极高接触角的硬涂层系统和/或表面。此外，与已知的现有技术相比，这些聚氨酯树脂的吸污倾向也大大降低。
• FLUORMODIFIZIERTE REAKTIVHARZSYSTEME, VERFAHREN ZUR IHRER HERSTELLUNG UND DEREN VERWENDUNG
  申请人：Construction Research and Technology GmbH

  公开号：EP1791882A1

  公开（公告）日：2007-06-06
• FLÜSSIGE FLUORHALTIGE ZUSAMMENSETZUNGEN FÜR DIE OBERFLÄCHENBEHANDLUNG MINERALISCHER UND NICHTMINERALISCHER UNTERGRÜNDE
  申请人：Evonik Degussa GmbH

  公开号：EP1812498B1

  公开（公告）日：2014-05-14
• Fluorine compound, liquid repellent membrane using the same and product using the same
  申请人：Sasaki Hiroshi

  公开号：US20050194588A1

  公开（公告）日：2005-09-08

  The present invention provides a liquid repellent membrane whose liquid repellency can be controlled by a varying physical stimulation; a novel fluorine compound which can be formed into the liquid repellent membrane; an electrical board, display device and color filter for display devices which are formed using the liquid repellent membrane by a method involving irradiation of visible light, which may be combined with a heating step, but needing no vacuum or ultraviolet ray irradiation process; methods for producing an electrical board, display device and color filter for display devices; and a pH sensor and ion sensor working on measurement of changed liquid repellency. The fluorine compound having liquid repellency is provided with a site at which it can be bound to a functional group, e.g., compound having a pigment unit.