2,2,2-三氯-1-甲氧基乙醇 | 18271-82-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 中文名称: 2,2,2-三氯-1-甲氧基乙醇
• 英文名称: chloral methyl hemiacetal
• 英文别名: 2,2,2-trichloro-1-methoxyethan-1-ol；Chloral-monomethylacetal；Chloral-monomethanolat；1,1,1-Trichlor-2-hydroxy-2-methoxy-ethan；2,2,2-Trichlor-1-methoxyethanol；trichloroacetaldehyde methyl hemiacetal；Trichloracetaldehyd-monomethylacetal；2,2,2-Trichlor-1-methoxy-aethanol；2,2,2-trichloro-1-methoxy-ethanol；Chloral-methylalkoholat；1-methoxy-2,2,2-trichloro-ethanol；2,2,2-Trichloro-1-methoxyethanol
• CAS: 18271-82-4
• 化学式: C₃H₅Cl₃O₂
• 分子量: 179.43
• InChiKey: LVMUSFXOLZJHFU-UHFFFAOYSA-N

物化性质

• 沸点：
  98-100 °C
• 密度：
  1.540±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,2-三氯-1-甲氧基乙醇 在 吡啶 、 氯化亚砜 、 苯 作用下， 生成 1,1,1,2-四氯-2-甲氧基-乙烷
  参考文献：
  名称：

  Fluorine containing ethers and process for preparation thereof

  摘要：

  公开号：

  US02803665A1
• 作为产物：
  描述：

  3-Trichlormethyl-2,4,6-trioxaheptan 在 甲醇 、 硫酸 作用下， 生成 2,2,2-三氯-1-甲氧基乙醇
  参考文献：
  名称：

  Mamedov,S.; Gadzhizade,F., Journal of general chemistry of the USSR, 1963, vol. 33, p. 817 - 821

  摘要：

  DOI：

文献信息

• Herbicidal composition containing dioxolane, dioxane, or dioxepane
  申请人：Magyar Tudomanvos Akademia Kozponti Kemiai Kutato Intezete Nitrokemia

  公开号：US05116402A1

  公开（公告）日：1992-05-26

  The invention relates to a herbicidal composition which contains, besides binding, wetting, dispersing, emulsifying agents, solvents and/or surface-active substances, herbicides as active agent of thiocarbamate, carbamate, acid amide or urea type alone or in a combination, furthermore as antidote a compound of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, independently of each other, are hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-4 cyanoalkyl, C.sub.1-6 haloalkyl, phenyl-C.sub.1-4 -haloalkyl, phenyl, halogenphenyl, C.sub.1-4 -alkyl-phenyl, C.sub.1-4 -alkoxyphenyl, furfuryl; R.sup.3 and R.sup.4, independently of each other, are hydrogen, C.sub.1-18 -alkyl, C.sub.2-4 -haloalkyl, C.sub.2-4 -cyanoalkyl, C.sub.1-4 -alkoxy-C.sub.2-4 -alkyl, C.sub.5-6 -cycloalkyl, phenyl-C.sub.1-4 -alkyl, C.sub.3-4 -alkenyl, phenyl-C.sub.3-4 -alkenyl, di-C.sub.1-4 -alkylamino-C.sub.2-4 -alkyl, hydroxy-C.sub.2-6 -alkyl, furfuryl, tetrahydrofurfuryl, C.sub.1-4 -alkoxy-C.sub.2-4 -alkoxy-C.sub.2-4 -alkyl; R.sup.3 and R.sup.4, together, are C.sub.2-4 -alkylene, C.sub.4 -alkenylene, glucofuranosylene, acetoxy-C.sub.3 -alkylene, C.sub.1-4 -alkoxy-C.sub.3 -alkylene, hydroxy-C.sub.3 -alkylene, halogen-C.sub.3 -alkylene; wherein the quantity of the antidote lies between 0.01 and 15 parts by weight referred to 1 part by weight of herbicidal agent, furthermore the composition contains altogether 0.1 to 95 percent by weight of the herbicidal agents and the antidote.

  该发明涉及一种除草剂组合物，除了包含粘结、润湿、分散、乳化剂、溶剂和/或表面活性物质之外，还包含硫代氨基甲酸酯、氨基甲酸酯、酸酰胺或尿素类活性剂作为活性剂，可以单独使用或组合使用，此外，作为解毒剂的一般式I的化合物如下：其中R.sup.1和R.sup.2，彼此独立，是氢、C.sub.1-6烷基、C.sub.2-6烯基、C.sub.1-4氰基烷基、C.sub.1-6卤代烷基、苯基-C.sub.1-4-卤代烷基、苯基、卤代苯基、C.sub.1-4-烷基苯基、C.sub.1-4-烷氧基苯基、呋喃甲基；R.sup.3和R.sup.4，彼此独立，是氢、C.sub.1-18-烷基、C.sub.2-4-卤代烷基、C.sub.2-4-氰基烷基、C.sub.1-4-烷氧基-C.sub.2-4-烷基、C.sub.5-6-环烷基、苯基-C.sub.1-4-烷基、C.sub.3-4-烯基、苯基-C.sub.3-4-烯基、二-C.sub.1-4-烷基氨基-C.sub.2-4-烷基、羟基-C.sub.2-6-烷基、呋喃基、四氢呋喃基、C.sub.1-4-烷氧基-C.sub.2-4-烷氧基-C.sub.2-4-烷基；R.sup.3和R.sup.4，一起，是C.sub.2-4-烷基烯、C.sub.4-烯基、葡萄糖呋喃基、乙酸氧基-C.sub.3-烷基烯、C.sub.1-4-烷氧基-C.sub.3-烷基烯、羟基-C.sub.3-烷基烯、卤代-C.sub.3-烷基烯；解毒剂的量在除草剂的1份重量中介于0.01和15份重量之间，此外，该组合物总共含有0.1至95重量百分比的除草剂和解毒剂。
• Lewis acid catalysis of the ene addition of chloral and bromal to olefins; product studies
  作者：Jill P. Benner、G. Bryon Gill、Stephen J. Parrott、Brian Wallace

  DOI：10.1039/p19840000291

  日期：——

  The addition of chloral and bromal to a variety of alkyl-substituted alkenes has been investigated. The effect on the reaction of varying the Lewis acid catalyst and the structure of the substrate have been studied. Anhydrous AlCl3 was found to be the most effective catalyst, and ene-type adducts were the major products in most cases. Side reactions were observed with the less reactive systems leading

  已经研究了向各种烷基取代的烯烃中添加氯醛和溴代醛的方法。研究了路易斯酸催化剂的变化对反应的影响以及底物的结构。发现无水AlCl 3是最有效的催化剂，并且在大多数情况下，烯类加合物是主要产物。观察到副反应与反应性较低的系统不同，导致形成三卤代酮，氢卤化的烯加合物和环状醚。在某些情况下，建立了优化烯加合物收率的条件。三卤代酮副产物可通过格利雅型反应方便地除去。
• Process for formylation of aromatic compounds
  申请人：Union Camp Corporation

  公开号：US05457239A1

  公开（公告）日：1995-10-10

  A process for the preparation of a formylated aromatic compound comprising contacting an aromatic compound with (i) a halogenated compound in the presence of a Lewis acid, and (ii) a base, is described. The subject process provides an efficient and effective means of preparing formylated compounds which may be useful in a wide variety of applications.

  本发明提供了一种制备醛基芳香化合物的方法，包括将芳香化合物与（i）卤代化合物在Lewis酸存在下接触，以及（ii）碱。该方法提供了一种高效和有效的制备醛基化合物的手段，这些化合物可能在各种应用中有用。
• Asymmetric Organocatalyzed Friedel–Crafts Reaction of Trihaloacetaldehydes and Phenols
  作者：David Svestka、Jan Otevrel、Pavel Bobal

  DOI：10.1002/adsc.202200180

  日期：2022.7.5

  Herein we report the asymmetric organocatalyzed method for the Friedel–Crafts reaction between activated phenols and trihaloacetaldehydes. A three-phase screening including 41 compounds was employed to identify a catalyst structure based on 3,5-dinitrobenzamide of 9-amino-epi-cinchonidine as the lead catalytic molecule. Under the optimized reaction conditions, the above catalyst offered trihalohydroxyalkylated

  在这里，我们报告了活化酚和三卤代乙醛之间的傅克反应的不对称有机催化方法。采用包括 41 种化合物的三相筛选来确定基于 9-氨基-表-辛可尼丁的 3,5-二硝基苯甲酰胺作为先导催化分子的催化剂结构。在优化的反应条件下，上述催化剂提供的三卤代羟基烷基化加合物的收率在 26% 到 92% 之间，对映体比在 69:31-99:1 之间。确定了29个条目的反应范围，并完成了对映体富集产物的多次后续转化。
• Synthesis and some properties of 2,2,2-trichloro-1-alkoxy-1-nitroxyethanes
  作者：A. I. Polyakov、L. N. Spiridonova

  DOI：10.1007/bf00854055

  日期：1973.3