2,2,4-三甲基二环[2.2.2]辛烷-3-酮 | 144340-75-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,2,4-三甲基二环[2.2.2]辛烷-3-酮
• 英文名称: 1,3,3-Trimethylbicyclo<2.2.2>octan-2-one
• 英文别名: Cineole；1,3,3-Trimethylbicyclo[2.2.2]octan-2-one
• CAS: 144340-75-0
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: SMWQXDIDJQZSOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  丙烯基三苯基锡 、 2,2,4-三甲基二环[2.2.2]辛烷-3-酮 在 苯基锂 作用下， 生成 1,3,3-Trimethyl-2-(2-propenyl)bicyclo<2.2.2>octan-2-ol
  参考文献：
  名称：

  A study on the structure/odour relationship of norpatchoulenol and patchoulol, II

  摘要：

  In continuation of studying structure/odour relationships of odourous compounds, the tricyclic patchouli-system is degraded to bicyclic structures by cutting the C6-C-7 bond (8 and 9) or by omitting the methylene group of C-11 (12). The olfactory properties are studied and described by using the key odour descriptors - woody, earthy, and camphoraceous.

  DOI：

  10.1007/bf00816853
• 作为产物：
  描述：

  2,6,6-三甲基-2,4-环己二烯-1-酮 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 、 苯 为溶剂， 85.0 ℃ 、8.11 MPa 条件下， 反应 2.5h， 生成 2,2,4-三甲基二环[2.2.2]辛烷-3-酮
  参考文献：
  名称：

  A study on the structure/odour relationship of norpatchoulenol and patchoulol, II

  摘要：

  In continuation of studying structure/odour relationships of odourous compounds, the tricyclic patchouli-system is degraded to bicyclic structures by cutting the C6-C-7 bond (8 and 9) or by omitting the methylene group of C-11 (12). The olfactory properties are studied and described by using the key odour descriptors - woody, earthy, and camphoraceous.

  DOI：

  10.1007/bf00816853

文献信息

• Pharmaceutical composition and method of manufacturing
  申请人：CURE PHARMACEUTICAL HOLDING CORP.

  公开号：US11331358B2

  公开（公告）日：2022-05-17

  The present invention provides for methods of obtaining an extract of Cannabis plant material as well as subsequent processing of the extract to provide a concentrate of Cannabis. The present invention also provides for pharmaceutical dosage forms (e.g., oral thin films and transdermal patches) that include the concentrate (or extract) of Cannabis, as well as methods of medical treatment that include administering the pharmaceutical dosage forms.

  本发明提供了获得大麻植物材料提取物的方法，以及对提取物进行后续加工以提 供大麻浓缩物的方法。本发明还提供了包括大麻浓缩物（或提取物）的药物剂型（如口服薄膜和透皮贴剂），以及包括施用药物剂型的医疗方法。
• DOSAGE FORM FOR CINEOLE
  申请人：Greve Harald

  公开号：US20160000722A1

  公开（公告）日：2016-01-07

  The invention relates to a dosage form containing cineole for peroral application in capsule form, wherein the dosage form containing cineole is designed as a capsule-in-capsule system, wherein the capsule-in-capsule system has an outer capsule (outside capsule) having an outer capsule shell and a plurality of inner capsules (inside capsules) located in the outer capsule, wherein the inner capsules are completely enclosed by the capsule shell of the outer capsule and the inner capsules are designed as microcapsules, which each contain the active ingredient 1,8-cineole. The invention further relates to the production and use of said dosage form containing cineole.
• PHARMACEUTICAL COMPOSITION AND METHOD OF MANUFACTURING
  申请人：CURE PHARMACEUTICAL HOLDING CORP.

  公开号：US20200246406A1

  公开（公告）日：2020-08-06

  The present invention provides for methods of obtaining an extract of Cannabis plant material as well as subsequent processing of the extract to provide a concentrate of Cannabis . The present invention also provides for pharmaceutical dosage forms (e.g., oral thin films and transdermal patches) that include the concentrate (or extract) of Cannabis , as well as methods of medical treatment that include administering the pharmaceutical dosage forms.
• US3967629A
  申请人：——

  公开号：US3967629A

  公开（公告）日：1976-07-06
• A study on the structure/odour relationship of norpatchoulenol and patchoulol, II
  作者：Helmut Spreitzer

  DOI：10.1007/bf00816853

  日期：——

  In continuation of studying structure/odour relationships of odourous compounds, the tricyclic patchouli-system is degraded to bicyclic structures by cutting the C6-C-7 bond (8 and 9) or by omitting the methylene group of C-11 (12). The olfactory properties are studied and described by using the key odour descriptors - woody, earthy, and camphoraceous.