2,2-二甲基-1-(3-喹啉基)-1-丙醇 | 1179140-63-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2,2-二甲基-1-(3-喹啉基)-1-丙醇
• 英文名称: 2,2-dimethyl-1-(3-quinolinyl)-1-propanol
• 英文别名: 2,2-Dimethyl-1-quinolin-3-ylpropan-1-ol
• CAS: 1179140-63-6
• 化学式: C₁₄H₁₇NO
• 分子量: 215.295
• InChiKey: VMAJJKKZFHVJTC-UHFFFAOYSA-N

物化性质

• 熔点：
  177.4 °C
• 沸点：
  357.8±17.0 °C(Predicted)
• 密度：
  1.090±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-碘喹啉 在 tris-(dibenzylideneacetone)dipalladium(0) 、 potassium hydroxide 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 、 苯 为溶剂， 反应 40.0h， 生成 喹啉 、 2,2-二甲基-1-(3-喹啉基)-1-丙醇
  参考文献：
  名称：

  Preparation and Reaction of Quinolinyl (or Pyridinyl)phosphonium Salts with Base and Pivalaldehyde

  摘要：

  alpha- and gamma-Heteroaryltriphenylphosphonium iodides were prepared by reaction of the corresponding heteroaryl iodides with triphenylphosphine. Reaction of beta-heteroaryl iodides with triphenylphosphine in the presence of a palladium catalyst gave beta-heteroaryltriphenylphosphonium iodides. Elimination of the heteroaryl group was achieved by treating the heteroaryltriphenylphosphonium iodides with a base. Further, the heteroaryl group was trapped with pivalaldehyde to introduce a pivaloyl substituent onto the heteroaromatic ring.

  DOI：

  10.3987/com-11-12154

文献信息

• Preparation and Reaction of Quinolinyl (or Pyridinyl)phosphonium Salts with Base and Pivalaldehyde
  作者：Osamu Sugimoto、Minami Shimada、Akihiro Sato、Ken-ichi Tanji

  DOI：10.3987/com-11-12154

  日期：——

  alpha- and gamma-Heteroaryltriphenylphosphonium iodides were prepared by reaction of the corresponding heteroaryl iodides with triphenylphosphine. Reaction of beta-heteroaryl iodides with triphenylphosphine in the presence of a palladium catalyst gave beta-heteroaryltriphenylphosphonium iodides. Elimination of the heteroaryl group was achieved by treating the heteroaryltriphenylphosphonium iodides with a base. Further, the heteroaryl group was trapped with pivalaldehyde to introduce a pivaloyl substituent onto the heteroaromatic ring.