2,2-双(丙烷-2-基)6,6-甲氧基螺环[3.3]庚烷E-2,2-二甲酸 | 1118786-87-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,2-双(丙烷-2-基)6,6-甲氧基螺环[3.3]庚烷E-2,2-二甲酸
• 英文名称: 2,2-Bis(propan-2-yl) 6,6-dimethoxyspiro[3.3]heptane-2,2-dicarboxylate
• 英文别名: dipropan-2-yl 2,2-dimethoxyspiro[3.3]heptane-6,6-dicarboxylate
• CAS: 1118786-87-0
• 化学式: C₁₇H₂₈O₆
• mdl: MFCD11858161
• 分子量: 328.4
• InChiKey: ZCZRABRYWOITQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.882
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• DISPIROPYRROLIDINE DERIVATIVES
  申请人：Sugimoto Yuuichi

  公开号：US20120264738A1

  公开（公告）日：2012-10-18

  A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R 1 , R 2 , R 3 , ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

  提供了一种抑制小鼠双分子2（Mdm2）蛋白与p53蛋白相互作用并具有抗肿瘤活性的化合物。本发明提供了以下式（1）所代表的二螺环吡咯烷衍生物，其具有各种取代基，抑制Mdm2蛋白与p53蛋白之间的相互作用并具有抗肿瘤活性，其中式（1）中的R1、R2、R3、环A和环B分别具有规范中定义的相同含义。
• DISPIROPYRROLIDINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2684880A1

  公开（公告）日：2014-01-15

  A novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

  本发明提供了一种新型化合物，它能抑制小鼠双分 2（Mdm2）蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性。本发明提供了一种由下式（1）表示的二吡咯烷衍生物，该衍生物具有各种取代基，可抑制 Mdm2 蛋白和 p53 蛋白之间的相互作用并具有抗肿瘤活性，其中式（1）中的 R1、R2、R3、环 A 和环 B 分别具有与说明书中所定义的相同的含义。
• EP3753926A1
  申请人：——

  公开号：EP3753926A1

  公开（公告）日：2020-12-23
• SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR
  申请人：SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES

  公开号：US20210047290A1

  公开（公告）日：2021-02-18

  Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The inhibitor of the present invention has a structure as represented by general formula (I), wherein the definitions of Ar, E, Y, X, V, D, W, B, ring A and ring B are as shown in the description and claims. Also disclosed in the present invention is a preparation method for the inhibitor. The compound of general formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor for preparing a medicament for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.
• US8629133B2
  申请人：——

  公开号：US8629133B2

  公开（公告）日：2014-01-14