2,4-二羟基-4-甲氧基二氢查尔酮 | 53596-71-7

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2,4-二羟基-4-甲氧基二氢查尔酮
• 英文名称: 1-(2,4-Dihydroxyphenyl)-3-(4-methoxycyclohexa-2,4-dien-1-yl)prop-2-en-1-one
• CAS: 53596-71-7
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.29
• InChiKey: WKFJTWMOXONXLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• 海关编码：
  2914501900

文献信息

• METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES
  申请人：Martineau Louis C.

  公开号：US20140135359A1

  公开（公告）日：2014-05-15

  The present invention provides a computer-assisted method of generating a protonophore requiring the use of a computer including a processor. The method includes: designing the protonophore, calculating, using the processor, an estimated protonophoric activity; producing the protonophore if the estimated protonophoric activity corresponds to an U 50 of about 20 μM or less; and determining the uncoupling activity of the protonophore. The present invention also provides novel protonophores that meet the above requirement and their methods of use.

  本发明提供了一种利用计算机辅助的方法来生成需要使用处理器的质子载体。该方法包括：设计质子载体，使用处理器计算估计的质子载体活性；如果估计的质子载体活性对应于大约20微米或更少的U50，则生产质子载体；并确定质子载体的解耦活性。本发明还提供了符合上述要求的新型质子载体及其使用方法。
• COMPOUNDS FROM AN EXTRACT OF ARTEMISIA AND METHODS FOR TREATING DISORDERS
  申请人：Rutgers, The State University of New Jersey

  公开号：EP1996212A2

  公开（公告）日：2008-12-03
• Compounds from an extract of Artemisia and methods for treating disorders
  申请人：Ribnicky M. David

  公开号：US20070224301A1

  公开（公告）日：2007-09-27

  This invention comprises an extract of Artemisia dracunculus that can be used for the treatment and prevention of diabetes, diabetic complications, metabolic syndrome and other comorbidities that share the underlying commonality of insulin resistance. The invention includes the identity of six compounds from the extract that contribute to the activity of the extract by inhibiting protein tyrosine phosphatase-1B (PTP-1B) activity, phosphoenolpyruvate carboxykinase (PEPCK) gene expression or aldose reductase activity (ALR2). The compounds include 4,5-Di-O-caffeoylquinic acid, davidigenin, 6-demethoxycapillarisin, 2′,4-dihydroxy-4′-methoxydihydrochalcone, 2′,4′-dihydroxy-4-methoxdihydrochalcone and sakuranetin.
• [EN] COMPOUNDS FROM AN EXTRACT OF ARTEMISIA AND METHODS FOR TREATING DISORDERS<br/>[FR] COMPOSÉS PROVENANT D'UN EXTRAIT D'ARMOISE ET PROCÉDÉS SERVANT À TRAITER DES TROUBLES
  申请人：RUTGERS THE STATES UNIVERSITY

  公开号：WO2007109217A2

  公开（公告）日：2007-09-27

  [EN] This invention comprises an extract of Artemisia dracunculus that can be used for the treatment and prevention of diabetes, diabetic complications, metabolic syndrome and other comorbidities that share the underlying commonality of insulin resistance. The invention includes the identity of six compounds from the extract that contribute to the activity of the extract by inhibiting protein tyrosine phosphatase- 1B (PTP-1B) activity, phosphoenolpyruvate carboxykinase (PEPCK) gene expression or aldose reductase activity (ALR2). The compounds include 4, 5-Di-O- caffeoylquinic acid, davidigenin, 6-demethoxycapilIarisin, 2',4-dihydroxy-4'- methoxydihydrochalcone, 2',4'-dihydroxy-4-.rnethoxydihydrochalcone and sakuranetin.
  [FR] Cette invention concerne un extrait d'Artemisia dracunculus qui peut être utilisé pour le traitement et la prévention du diabète, de complications diabétiques, d'un syndrome métabolique et d'autres comorbidités qui ont le point commun sous-jacent de la résistance à l'insuline. L'invention concerne six composés identifiés provenant de l'extrait qui contribuent à l'activité de l'extrait en inhibant l'activité de la protéine tyrosine phosphatase-1B (PTP-1B), l'expression du gène de la phosphoénolpyruvate carboxykinase (PEPCK) ou l'activité de l'aldose réductase (ALR2). Les composés comprennent l'acide 4,5-di-O-caféoylquinique, la davidigenine, la 6-déméthoxycapillarisine, la 2',4-dihydroxy-4'-méthoxydihydrochalcone, la 2',4'-dihydroxy-4-méthoxydihydrochalcone et la sakuranetine.
• [EN] COMPOSITIONS AND METHODS TO MODULATE GLUCOSE HOMEOSTASIS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR MODULER UNE HOMÉOSTASIE DU GLUCOSE
  申请人：THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV AND AGRICULTURAL AND MECHANICAL COLLEGE

  公开号：WO2021113473A1

  公开（公告）日：2021-06-10

  This invention is directed to compositions and methods for modulating glucose homeostasis.