2,5-二甲基-4-乙氧基-3(2H)-呋喃酮 | 65330-49-6

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 中文名称: 2,5-二甲基-4-乙氧基-3(2H)-呋喃酮
• 中文别名: 呋喃酮乙醚；4-乙氧基-2,5-二甲基-3(2H)呋喃酮；4-乙氧基-2,5-二甲基-3(2H)呋喃酮;呋喃酮乙醚;2,5-二甲基-4-乙氧基-3(2H)-呋喃酮
• 英文名称: 2,5-dimethyl-4-ethoxy-3(2H)-furanone
• 英文别名: 4-ethoxy-2,5-dimethylfuran-3-one
• CAS: 65330-49-6
• 化学式: C₈H₁₂O₃
• mdl: MFCD08457804
• 分子量: 156.181
• InChiKey: AILFSZXBRNLVHY-UHFFFAOYSA-N

物化性质

• 沸点：
  239 ºC
• 密度：
  1.07
• 闪点：
  89 ºC
• LogP：
  0.779 (est)
• 保留指数：
  1090

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

制备方法与用途

用途广泛，既是重要水果，也是优质的调酒香精原料。

反应信息

• 作为产物：
  描述：

  2,5-二甲基-4-羟基-3(2H)-呋喃酮 、 乙醇 在 对甲苯磺酸 作用下， 反应 6.0h， 以80%的产率得到2,5-二甲基-4-乙氧基-3(2H)-呋喃酮
  参考文献：
  名称：

  Direct Formation of 4-Alkoxy Derivatives from 2,5-Dimethyl-4-hydroxy-3(2H)-furanone and Aliphatic Alcohols

  摘要：

  The reaction of 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DHF) with aliphatic alcohols using a small amount of strong acid catalyst proceeded, in an analogous way to classical carboxylic acid ester formation, to give good yields of the 4-alkoxy derivatives. This raises the possibility that this type of ester-like formation might occur in foods that contain both DHF and alcohols. Odor threshold determinations of 4-alkoxy DHF derivatives from a number of common food alcohols including methanol, ethanol, butanol, 3-methylbutanol, and (Z)-3-hexenol showed them, however, to be relatively weak odorants.

  DOI：

  10.1021/jf950451g

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• FLAVOUR ADDITIVES
  申请人：Mars, Incorporated

  公开号：EP3461347A1

  公开（公告）日：2019-04-03

  The present invention relates to the use of a first amino acid selected from the group consisting of glycine, alanine, cysteine, histidine, leucine, methionine, phenylalanine, serine, tryptophan and tyrosine or a mixture of two or more thereof; a second amino acid selected from the group consisting of aspartic acid, cystine, glutamic acid, glutamine, isoleucine, lysine, aspartic acid, ornithine, threonine, valine, proline and hydroxyproline or a mixture of two or more thereof and one or more furanones for increasing the palatability of a foodstuff to a companion animal. The invention also relates to a pet foodstuff or supplement comprising a first amino acid selected from the group consisting of glycine, alanine, cysteine, histidine, leucine, methionine, phenylalanine, serine, tryptophan and tyrosine or a mixture of two or more thereof; a second amino acid selected from the group consisting of aspartic acid, cystine, glutamic acid, glutamine, isoleucine, lysine, aspartic acid, ornithine, threonine, valine, proline and hydroxyproline or a mixture of two or more thereof and one or more furanones, and also to a method of increasing the palatability of a foodstuff to a companion animal.

  本发明涉及选自甘氨酸、丙氨酸、半胱氨酸、组氨酸、亮氨酸、蛋氨酸、苯丙氨酸、丝氨酸、色氨酸和酪氨酸或其两种或两种以上混合物的第一种氨基酸的用途；第二种氨基酸，选自由天冬氨酸、胱氨酸、谷氨酸、谷氨酰胺、异亮氨酸、赖氨酸、天门冬氨酸、鸟氨酸、苏氨酸、缬氨酸、脯氨酸和羟脯氨酸或其两种或两种以上的混合物组成的组，以及一种或多种呋喃酮，用于增加伴侣动物对食品的适口性。本发明还涉及一种宠物食品或补充剂，包含选自甘氨酸、丙氨酸、半胱氨酸、组氨酸、亮氨酸、蛋氨酸、苯丙氨酸、丝氨酸、色氨酸和酪氨酸或其两种或两种以上混合物的第一种氨基酸；第二种氨基酸，选自由天冬氨酸、胱氨酸、谷氨酸、谷氨酰胺、异亮氨酸、赖氨酸、天门冬氨酸、鸟氨酸、苏氨酸、缬氨酸、脯氨酸和羟脯氨酸或其两种或两种以上的混合物以及一种或多种呋喃酮组成的组。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10392371B2

  公开（公告）日：2019-08-27

  Provided herein are compounds which are useful as cooling sensation compounds.

  本文提供的化合物可用作冷感化合物。
• Pro-fragrance composition
  申请人：AQDOT LIMITED

  公开号：US10695277B2

  公开（公告）日：2020-06-30

  A pro-fragrance composition includes a cucurbituril in complex with a fragrance molecule and use of the compositions in counteracting malodour. The cucurbituril is present as a mixture, wherein the mixture includes at least two different cucurbiturils selected from CB[5], CB[6], CB[7] and CB[8]. The complexed fragrance molecule is released when the composition is exposed to a stimulus. Also provides methods for the preparation of pro-fragrance complexes of cucurbiturils and fragrance molecules.

  一种促香组合物包括葫芦素与香味分子的复合物，该组合物用于对抗恶臭。葫芦素以混合物的形式存在，其中混合物包括至少两种选自 CB[5]、CB[6]、CB[7] 和 CB[8] 的不同葫芦素。当组合物受到刺激时，络合的香味分子就会释放出来。还提供了葫芦素和香味分子的原香味复合物的制备方法。