2,6-二(环己基亚基)环己烷-1-酮 | 3293-32-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,6-二(环己基亚基)环己烷-1-酮
• 英文名称: 2,6-dicyclohexylidenecyclohexanone
• 英文别名: 2,6-dicyclohexylidencyclohexanone；2,6-Dicyclohexyliden-cyclohexanon；2,6-di(cyclohexylidene)cyclohexan-1-one
• CAS: 3293-32-1
• 化学式: C₁₈H₂₆O
• 分子量: 258.404
• InChiKey: UXLWGCCTUFJXDJ-UHFFFAOYSA-N

物化性质

• 熔点：
  145-146 °C
• 沸点：
  192 °C(Press: 8 Torr)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914299000

反应信息

• 作为反应物：
  描述：

  2,6-二(环己基亚基)环己烷-1-酮 在 aluminum oxide 、 sodium hydroxide 、 palladium/alumina 作用下， 生成 2,6-二苯基苯酚
  参考文献：
  名称：

  Munk; Plesek, Collection of Czechoslovak Chemical Communications, 1957, vol. 22, p. 1691,1693

  摘要：

  DOI：
• 作为产物：
  描述：

  环己酮 在 aluminum oxide 作用下， 320.0 ℃ 、3.04 MPa 条件下， 生成 2,6-二(环己基亚基)环己烷-1-酮
  参考文献：
  名称：

  Petrow, Bulletin de la Societe Chimique de France, 1928, vol. <4> 43, p. 1274

  摘要：

  DOI：

文献信息

• The Influence of the Preparation Method on the Physico-Chemical Properties and Catalytic Activities of Ce-Modified LDH Structures Used as Catalysts in Condensation Reactions
  作者：Alexandra-Elisabeta Stamate、Rodica Zăvoianu、Octavian Dumitru Pavel、Ruxandra Birjega、Andreea Matei、Marius Dumitru、Ioana Brezeștean、Mariana Osiac、Ioan-Cezar Marcu

  DOI：10.3390/molecules26206191

  日期：——

  mechanochemical reactions are the subjects of mechanochemistry, a special branch of chemistry studied intensively since the 19th century. Herein, we comparably describe two synthesis methods used to obtain the following layered double hydroxide doped with cerium, Mg3Al0.75Ce0.25(OH)8(CO3)0.5·2H2O: the mechanochemical route and the co-precipitation method, respectively. The influence of the preparation method

  机械活化和机械化学反应是机械化学的主题，机械化学是自 19 世纪以来深入研究的化学的一个特殊分支。在此，我们比较描述了用于获得以下掺杂铈的层状双氢氧化物Mg 3 Al 0.75 Ce 0.25 (OH) 8 (CO 3 ) 0.5 ·2H 2 O的两种合成方法：机械化学路线和共沉淀法，分别。通过 XRD、SEM、EDS、XPS、DRIFT、RAMAN、DR-UV-VIS、碱度、酸度、实际/堆积密度和 BET 测量等多种技术确定制备方法对物理化学性质的影响也分析了。获得的样品缩写为HTCe-PP（通过共沉淀法制备）和HTCe-MC（通过机械化学法制备），及其相应的混合氧化物Ce-PP（由HTCe-PP产生）和Ce-MC（由HTCe产生） -MC)，被用作环己酮自缩合反应和两次克莱森-施密特缩合反应的基础催化剂，其中涉及芳香醛和酮之间在不同摩尔比下的反应，从黄酮类化合物中合成具有显着生物活性的化合物家族，即查尔酮（1
• Lactate Stress Testing in 155 Patients with Mitochondriopathy
  作者：Josef Finsterer、Erika Milvay

  DOI：10.1017/s0317167100001712

  日期：2002.2

  Few data are available about the diagnostic yield of the lactate stress test (LST) in a large group of patients with mitochondriopathy (MCP).

  Serum lactate was determined once before, three times during, and once after a 15-minute, constant 30W workload on a bicycle in 62 controls, aged 17 to 84 years, 155 patients with MCP, aged 17 to 87 years, and 31 patients with neurological disorders other than MCP.

  Lactate's upper reference limits at rest, 5, 10, 15 minutes after starting, and 15 minutes after finishing the exercise were 2.0, 2.1, 2.1, 2.1 and 1.8 mmol/l respectively. The test was regarded abnormal if more than two of the five lactate values exceeded the cut-off levels. Among the 103 patients with abnormal LST, 64 (62 %) had normal resting lactate. The sensitivity of the test was 67% and the specificity 94%.

  The LST proved to have a high sensitivity and specificity in the detection of patients with MCP, being thus a simple but powerful tool to assess the impaired oxidative metabolism in MCP patients.

  方法：对62名年龄在17至84岁之间的对照组患者、155名年龄在17至87岁之间的线粒体病变（MCP）患者以及31名MCP以外的神经系统疾病患者进行血清乳酸测定。结果：休息时、开始运动后 5 分钟、10 分钟、15 分钟和结束运动后 15 分钟的乳酸参考上限分别为 2.0、2.1、2.1、2.1 和 1.8 毫摩尔/升。如果五个乳酸值中有两个以上超过临界值，则测试结果为异常。在 103 名 LST 异常的患者中，64 人（62%）的静息乳酸正常。结论：事实证明，LST 在检测 MCP 患者方面具有很高的灵敏度和特异性，是评估 MCP 患者氧化代谢受损情况的一种简单而强大的工具。
• METHOD FOR THE PRODUCTION OF 4,4'-[1-TRIFLUOROMETHYL)ALKYLIDENE]-BIS-(2,6-DIPHENYLPHENOLS)
  申请人：Gralla Gabriele

  公开号：US20100312020A1

  公开（公告）日：2010-12-09

  The present invention relates to a process for preparing 4,4′-[1-(trifluoromethyl)alkylidene]bis(2,6-diphenylphenols), in particular for preparing 4,4′-[1-(trifluoromethyl)ethylidene]bis(2,6-diphenylphenol), which comprises the self-condensation of cyclohexanone in the presence of a basic catalyst to form tricyclic condensation products, dehydrogenation of the resulting tricyclic condensation products in the presence of a supported transition metal catalyst in the condensed phase to form 2,6-diphenylphenol and reaction of the 2,6-diphenylphenol with a trifluoromethyl ketone. The invention further provides an improved process for preparing 2,6-diphenylphenol by aldol self-condensation of cyclohexanone.

  本发明涉及一种制备4,4'-[1-(三氟甲基)烷基亚甲基]二(2,6-二苯基酚)的方法，特别是制备4,4'-[1-(三氟甲基)乙基亚甲基]二(2,6-二苯基酚)的方法，包括在碱性催化剂存在下环己酮的自缩合反应，形成三环缩合产物，然后在支持的过渡金属催化剂存在下，在凝聚相中脱氢，形成2,6-二苯基酚，最后将2,6-二苯基酚与三氟甲基酮反应。本发明还提供了一种改进的通过环己酮的自缩合反应制备2,6-二苯基酚的方法。
• Tailored texture synthesized LDH catalysts in the presence of quaternary ammonium salts
  作者：Bogdan Cojocaru、Bogdan Ciprian Jurca、Rodica Zăvoianu、Ruxandra Bîrjega、Vasile I. Pârvulescu、Octavian Dumitru Pavel

  DOI：10.1016/j.catcom.2022.106485

  日期：2022.10

  Tetramethylammonium- and tetrabutylammonium-hydroxides operate as alternative bases to the traditional inorganic ones for the LDH structures synthesis with controlled texture. This is valuable for both co-precipitation and mechano-chemical routes, where these organic bases limited the production of wastewaters by more than ten times, the contamination of hydrotalcites with other metallic cations, an

  四甲基铵和四丁基氢氧化铵可作为传统无机碱的替代碱，用于具有受控质地的 LDH 结构合成。这对于共沉淀和机械化学路线都很有价值，在这些路线中，这些有机碱将废水的产生限制了十倍以上，水滑石被其他金属阳离子污染，大大减少了合成过程中消耗的能量，以及，也可作为生成预定孔隙率的模板。产生的 LDH 的结晶度受烷基铵阳离子的性质影响。催化剂的催化行为已经在氰乙基化、克莱森-施密特和自环己酮缩合反应中进行了评估。
• Optimization of a cyclohexanone distillation stage in the presence of alkali
  作者：I. L. Glazko、S. V. Levanova、E. A. Martynenko、A. A. Sokolova

  DOI：10.1134/s1070427211100156

  日期：2011.10

  Kinetics of two reactions: hydrolysis of esters and condensation of cyclohexanone in an alkaline environment, was studied in model mixtures. Derived kinetic equations were used to assess optimal parameters of proceeding cyclohexanone distillation in the presence of alkali.