2,N-二羟基-2-甲基丙脒 | 15485-97-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,N-二羟基-2-甲基丙脒
• 英文名称: 2,N-dihydroxy-2-methylpropionamidine
• 英文别名: N',2-dihydroxy-2-methylpropanamidine；N,2-Dihydroxy-2-methylpropanimidamide；N',2-dihydroxy-2-methylpropanimidamide
• CAS: 15485-97-9
• 化学式: C₄H₁₀N₂O₂
• mdl: MFCD05662937
• 分子量: 118.136
• InChiKey: WNNSNZSHDOGSHA-UHFFFAOYSA-N

物化性质

• 熔点：
  52 °C(Solv: ethyl ether (60-29-7))
• 沸点：
  209.2±42.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  2,N-二羟基-2-甲基丙脒 、 2-(2-aminopyrimidin-5-yl)-4-morpholinylthieno[3,2-d]pyrimidine-6-carboxylic acid 在 N,N'-羰基二咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  WO2008/73785

  摘要：

  公开号：
• 作为产物：
  描述：

  丙酮氰醇 在 盐酸羟胺 、 sodium carbonate 作用下， 以 乙醇 为溶剂， 以1 g的产率得到2,N-二羟基-2-甲基丙脒
  参考文献：
  名称：

  [EN] (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA
  [FR] DÉRIVÉS DE (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)MÉTHANONE UTILISÉS EN TANT QUE STABILISATEURS DE PAH MUTANTE POUR TRAITER LA PHÉNYLCÉTONURIE

  摘要：

  The disclosure relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein, m, R1-R5, R5A, and L are defined herein. These compounds are useful in methods for stabilizing a mutant PAH protein or reducing blood phenylalanine concentration in a subject suffering from phenylketonuria. In some embodiments, the mutant PAH protein contains at least one R408W, R261Q, R243Q, Y414C, L48S, A403V, I65T, R241C, L348V, R408Q, or V388M mutation. In other embodiments, the mutant PAH protein contains at least one R408W, Y414C, I65T, F39L, R408Q, L348V, R261Q, A300S, or L48S mutation.

  公开号：

  WO2023164233A1

文献信息

• GRISEOFULVIN COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20200216433A1

  公开（公告）日：2020-07-09

  The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R 1 : a C1-C6 alkyl group or the like, R 2 : a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R 3 , R 3′ : a C1-C6 alkyl group or the like]

  本发明旨在解决提供用于预防或治疗中枢性炎症性疾病的化合物或其药理上可接受的盐的问题。本发明提出了一种通式（I）的化合物或其药理上可接受的盐作为解决问题的手段。[R1：C1-C6烷基等，R2：C1-C6烷基等，A：5员芳香杂环等，R3，R3'：C1-C6烷基等]
• PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE
  申请人：Castanedo Georgette

  公开号：US20080269210A1

  公开（公告）日：2008-10-30

  Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

  化合物Ia-d的化学式中，X为S或O，mor为吗啡啶基团，R3为单环杂芳基团，包括立体异构体、几何异构体、互变异构体、溶剂化物、代谢产物和其药学上可接受的盐，对于调节脂质激酶（包括PI3K）的活性以及治疗由脂质激酶介导的癌症等疾病具有用处。本文揭示了使用化合物Ia-d进行哺乳动物细胞中的体外、体内和原位诊断、预防或治疗此类疾病或相关病理条件的方法。
• HETEROARYL-SUBSTITUTED PIPERIDINES
  申请人：Heimbach Dirk

  公开号：US20090306139A1

  公开（公告）日：2009-12-10

  The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.

  本发明涉及新型杂环芳基取代哌啶，其制备过程，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是心血管疾病和肿瘤疾病。
• Heteroaryl-substituted piperidines
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US08119663B2

  公开（公告）日：2012-02-21

  The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumor diseases.

  本发明涉及新型杂环芳基取代哌啶，其制备过程，以及它们用于治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物，特别是心血管疾病和肿瘤疾病。
• Schiff,H., Justus Liebigs Annalen der Chemie, 1902, vol. 321, p. 369
  作者：Schiff,H.

  DOI：——

  日期：——