N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine
• 英文别名: N-[(E)-(3-bromophenyl)methylideneamino]-7-chloroquinolin-4-amine
• 化学式: C₁₆H₁₁BrClN₃
• 分子量: 360.64
• InChiKey: JJTYWBMDLBXULI-KEBDBYFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以62%的产率得到3-bromobenzaldehyde (E)-(7-chloro-1-methyl-4(1H)-quinolinylidene)hydrazone
  参考文献：
  名称：

  A new and potent class of quinoline derivatives against cancer

  摘要：

  A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in mu g/cm(3). These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 mu g/cm(3). These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.

  DOI：

  10.1007/s00706-015-1570-0