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N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine

中文名称
——
中文别名
——
英文名称
N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine
英文别名
N-[(E)-(3-bromophenyl)methylideneamino]-7-chloroquinolin-4-amine
N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine化学式
CAS
——
化学式
C16H11BrClN3
mdl
——
分子量
360.64
InChiKey
JJTYWBMDLBXULI-KEBDBYFISA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5.1
  • 重原子数:
    21
  • 可旋转键数:
    3
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    37.3
  • 氢给体数:
    1
  • 氢受体数:
    3

反应信息

  • 作为反应物:
    描述:
    N-[(E)-(3-bromophenyl)methyleneamino]-7-chloro-quinolin-4-amine碘甲烷potassium carbonate 作用下, 以 丙酮 为溶剂, 反应 0.5h, 以62%的产率得到3-bromobenzaldehyde (E)-(7-chloro-1-methyl-4(1H)-quinolinylidene)hydrazone
    参考文献:
    名称:
    A new and potent class of quinoline derivatives against cancer
    摘要:
    A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in mu g/cm(3). These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 mu g/cm(3). These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.
    DOI:
    10.1007/s00706-015-1570-0
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