2-(2-呋喃)-4(5)-(2-呋喃)-1H-咪唑 | 91037-91-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(2-呋喃)-4(5)-(2-呋喃)-1H-咪唑
• 英文名称: 2-(2-furoyl)-4-(2-furyl)-1H-imidazole
• 英文别名: furan-2-yl-[4-(furan-2-yl)-1H-imidazol-2-yl]methanone；2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole；furan-2-yl-[5-(furan-2-yl)-1H-imidazol-2-yl]methanone
• CAS: 91037-91-1
• 化学式: C₁₂H₈N₂O₃
• 分子量: 228.207
• InChiKey: DKZNJXJLTVYBRA-UHFFFAOYSA-N

物化性质

• 沸点：
  455.6±48.0 °C(Predicted)
• 密度：
  1.342±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2-furyl)-2-oxoethyl(propyl)ammonium oxalate 在 ammonium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 2-(2-呋喃)-4(5)-(2-呋喃)-1H-咪唑
  参考文献：
  名称：

  Formation of 2-(2-furoyl)-4(5)-(2-furyl)-1H-imidazole in the Maillard reaction

  摘要：

  DOI：

  10.1016/0008-6215(88)84012-6

文献信息

• Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines via a cascade process
  作者：Cong Liu、Rongji Dai、Guowei Yao、Yulin Deng

  DOI：10.3998/ark.5550190.p008.270

  日期：——

  The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

  研究了由芳基甲基酮通过 DMSO-HBr 氧化和 Debus 反应的级联过程合成 (4 或 5)-芳基-2-芳酰基-1H-咪唑和 2-羟基-3,6-二芳基吡嗪。由于起始原料简单、条件温和、操作方便、咪唑和吡嗪衍生物的生物活性高，该方案在药物化学中具有很大的潜力。
• HUBER, BERNHARD;LEDL, FRANZ;SEVERIN, THEODOR;STANGL, ACHIM;PELEIDERER, GE+, CARBOHYDR. RES., 182,(1988) N 2, C. 301-306
  作者：HUBER, BERNHARD、LEDL, FRANZ、SEVERIN, THEODOR、STANGL, ACHIM、PELEIDERER, GE+

  DOI：——

  日期：——
• METHOD AND AGENTS FOR MEASURING PROTEIN AGING
  申请人：THE ROCKEFELLER UNIVERSITY

  公开号：EP0175764A1

  公开（公告）日：1986-04-02
• EP0175764B1
  申请人：——

  公开号：EP0175764B1

  公开（公告）日：1989-12-27
• DEVICES AND METHODS FOR DETERMINING A DISEASE STATE BASED TOTAL LENS FLUORESCENCE
  申请人：YuScan USA, LLC

  公开号：US20210097683A1

  公开（公告）日：2021-04-01

  A device is provided that may include an illuminator operable to interrogate at least a lens of an eye. The illuminator may include at least one light source and a lens positioned with respect to the light source to produce interrogating radiation. The device also may include a detector operable to image the total autofluorescence response of the lens of the eye as viewable through a pupil of the eye, the detector comprising an image sensor. The device can also include a controller operable to control operation of the illuminator and the detector. The controller may interrogate at least the lens of the eye by activating the illuminator for a select time, obtain at least one image of the total autofluorescence response of the lens at the detector during or immediately subsequent to the select time, and transmit the at least one image to a remote device.