2-(2-甲氧基苯氧基)丙酸甲酯 | 63857-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-甲氧基苯氧基)丙酸甲酯
• 英文名称: methyl 2-(2-methoxyphenoxy)propanoate
• CAS: 63857-99-8
• 化学式: C₁₁H₁₄O₄
• mdl: MFCD03130311
• 分子量: 210.23
• InChiKey: LUHNVBLQLUWKGK-UHFFFAOYSA-N

物化性质

• 沸点：
  272.6±15.0 °C(Predicted)
• 密度：
  1.101±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-甲氧基苯氧基)丙酸甲酯 、 乙二胺 在 三甲基铝 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 13.0h， 以86%的产率得到2-(1-(2-methoxyphenoxy)ethyl)-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  Might the observed α2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?

  摘要：

  We recently reported that the alpha(2)-adrenoreceptor (AR) ligand allyphenyline (9) significantly enhanced morphine analgesia (due to its alpha(2C)-AR agonism), was devoid of sedative side effects (due to its alpha(2A)-AR antagonism), prevented and reversed morphine tolerance and dependence. To highlight the molecular characteristics compatible with this behaviour and to obtain novel agents potentially useful in chronic pain and opioid addiction management, the allyl group of 9 was replaced by substituents of moderate steric bulk (MR) and positive or negative lipophilic (pi) and electronic (sigma) contributions in all the possible combinations. Effective novel alpha(2C)-agonists/alpha(2A)-antagonists (2, 3, 10, 12, and 17) were obtained. This study also demonstrated that contradictory combinations of the physicochemical parameters were similarly able to induce the alpha(2A)-activation. Since we had previously observed that the absolute configuration affected only the potency, but not the functional profile of the ligands, we hypothesized that the alpha(2A)-activation was governed by a ligand preferred conformation. From a structural overlay investigation it emerged that an extended conformation appeared to be associated with dual alpha(2C)-agonism/alpha(2A)-antagonism, whereas a folded conformation associated with alpha(2C)-/alpha(2A)-agonism. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.01.035
• 作为产物：
  描述：

  2-溴丙酸甲酯 、 木榴油 在 potassium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 18.0h， 以90%的产率得到2-(2-甲氧基苯氧基)丙酸甲酯
  参考文献：
  名称：

  Might the observed α2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?

  摘要：

  We recently reported that the alpha(2)-adrenoreceptor (AR) ligand allyphenyline (9) significantly enhanced morphine analgesia (due to its alpha(2C)-AR agonism), was devoid of sedative side effects (due to its alpha(2A)-AR antagonism), prevented and reversed morphine tolerance and dependence. To highlight the molecular characteristics compatible with this behaviour and to obtain novel agents potentially useful in chronic pain and opioid addiction management, the allyl group of 9 was replaced by substituents of moderate steric bulk (MR) and positive or negative lipophilic (pi) and electronic (sigma) contributions in all the possible combinations. Effective novel alpha(2C)-agonists/alpha(2A)-antagonists (2, 3, 10, 12, and 17) were obtained. This study also demonstrated that contradictory combinations of the physicochemical parameters were similarly able to induce the alpha(2A)-activation. Since we had previously observed that the absolute configuration affected only the potency, but not the functional profile of the ligands, we hypothesized that the alpha(2A)-activation was governed by a ligand preferred conformation. From a structural overlay investigation it emerged that an extended conformation appeared to be associated with dual alpha(2C)-agonism/alpha(2A)-antagonism, whereas a folded conformation associated with alpha(2C)-/alpha(2A)-agonism. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.01.035

文献信息

• Might the observed α2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?
  作者：Eleonora Diamanti、Fabio Del Bello、Giuseppe Carbonara、Antonio Carrieri、Giuseppe Fracchiolla、Mario Giannella、Valerio Mammoli、Alessandro Piergentili、Katariina Pohjanoksa、Wilma Quaglia、Mika Scheinin、Maria Pigini

  DOI：10.1016/j.bmc.2012.01.035

  日期：2012.3

  We recently reported that the alpha(2)-adrenoreceptor (AR) ligand allyphenyline (9) significantly enhanced morphine analgesia (due to its alpha(2C)-AR agonism), was devoid of sedative side effects (due to its alpha(2A)-AR antagonism), prevented and reversed morphine tolerance and dependence. To highlight the molecular characteristics compatible with this behaviour and to obtain novel agents potentially useful in chronic pain and opioid addiction management, the allyl group of 9 was replaced by substituents of moderate steric bulk (MR) and positive or negative lipophilic (pi) and electronic (sigma) contributions in all the possible combinations. Effective novel alpha(2C)-agonists/alpha(2A)-antagonists (2, 3, 10, 12, and 17) were obtained. This study also demonstrated that contradictory combinations of the physicochemical parameters were similarly able to induce the alpha(2A)-activation. Since we had previously observed that the absolute configuration affected only the potency, but not the functional profile of the ligands, we hypothesized that the alpha(2A)-activation was governed by a ligand preferred conformation. From a structural overlay investigation it emerged that an extended conformation appeared to be associated with dual alpha(2C)-agonism/alpha(2A)-antagonism, whereas a folded conformation associated with alpha(2C)-/alpha(2A)-agonism. (C) 2012 Elsevier Ltd. All rights reserved.