2-(pyrrolidin-1-yl)cyclohexanol | 93080-29-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(pyrrolidin-1-yl)cyclohexanol
• 英文别名: Cyclohexanol, 2-(1-pyrrolidinyl)-；2-pyrrolidin-1-ylcyclohexan-1-ol
• CAS: 93080-29-6
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: QPIDLIAAUJBCSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(pyrrolidin-1-yl)cyclohexanol 生成 2-环己烯醇
  参考文献：
  名称：

  Barieux,J.-J.; Gore,J., Bulletin de la Societe Chimique de France, 1971, p. 1649 - 1657

  摘要：

  DOI：
• 作为产物：
  描述：

  氧化环己烯 以 乙醚 、 水 为溶剂， 以1.499 g (89%)的产率得到2-(pyrrolidin-1-yl)cyclohexanol
  参考文献：
  名称：

  Benzothiophenes

  摘要：

  公开号：

  EP0905132B1

文献信息

• Asymmetric Amination of meso-Epoxide with Vegetable Powder as a Low-Toxicity Catalyst
  作者：Yuki Takeuchi、Tatsuhiro Asano、Kazuya Tsuzaki、Koichi Wada、Hiroyuki Kurata

  DOI：10.3390/molecules25143197

  日期：——

  This paper describes the scope and limitation of substrates subjected to asymmetric amination with epoxides catalyzed by a soluble soybean polysaccharide (Soyafibe S-DN), which we recently discovered from the reaction of 1,2-epoxycyclohexane with cyclopropylamine. Various meso-epoxides reacted with various amines afforded the corresponding products with good enantiomeric selectivity. Since it was found that pectin was found to have a catalytic ability after screening commercially available polysaccharides, we studied 33 different vegetable powders having pectic substances, and we found that many vegetable powders showed catalytic ability. These results should guide in using vegetable components as low-toxic catalysts for the production of pharmaceuticals.

  本文描述了由可溶性大豆多糖（Soyafibe S-DN）催化的环氧化合物与环丙胺不对称胺化反应所受限的基质范围和限制性。我们最近从1,2-环氧环己烷与环丙胺反应中发现了这种多糖。各种中间体环氧化合物与各种胺反应产生了相应的产物，具有良好的对映选择性。在筛选商业可获得的多糖后发现果胶具有催化能力后，我们研究了33种含有果胶物质的不同蔬菜粉末，发现许多蔬菜粉末显示出催化能力。这些结果应该指导在制药生产中使用蔬菜成分作为低毒性催化剂。
• The effect of different amine bases in the Swern oxidation of β-amino alcohols
  作者：William Chrisman、Bakthan Singaram

  DOI：10.1016/s0040-4039(97)00283-9

  日期：1997.3

  Swern oxidation of β-amino alcohols containing tertiary amino groups afforded the corresponding α-amino carbonyl compounds in fair to excellent yield. Yields were dependent on the steric requirement of the amine base used for the reaction and were optimized by the use of N-methylpyrrolidine, N-ethylpiperidine, or triethylamine, depending on the β-amino alcohol substrate.

  含有叔氨基的β-氨基醇的剧烈氧化得到相应的α-氨基羰基化合物，收率相当好。产率取决于用于反应的胺碱的空间要求，并且取决于β-氨基醇底物，通过使用N-甲基吡咯烷，N-乙基哌啶或三乙胺来优化产率。
• Mesoporous Titania-Iron(III) Oxide with Nanoscale Porosity and High Catalytic Activity for the Synthesis of β-Amino Alcohols and Benzimidazole Derivatives
  作者：Susmita Roy、Biplab Banerjee、Noor Salam、Asim Bhaumik、Sk. Manirul Islam

  DOI：10.1002/cctc.201500563

  日期：2015.9.1

  A mesoporous TiO2‐Fe2O3 mixed oxide material (MTF‐1E) with nanoscale porosity and a high BET surface area was synthesized using sodium dodecyl sulfate (SDS) as a structure‐directing agent. The material was characterized by powder XRD, high‐resolution TEM, N2 sorption, and NH3 temperature‐programmed desorption studies. The catalyst shows an excellent regioselectivity for the ring‐opening of epoxides

  使用十二烷基硫酸钠（SDS）作为结构导向剂，合成了具有纳米级孔隙率和高BET表面积的介孔TiO 2 -Fe 2 O 3混合氧化物材料（MTF-1E）。该材料的特点是粉末XRD，高分辨率TEM，N 2吸附和NH 3温度程序解吸研究。在室温下无溶剂条件下，该催化剂对胺类化合物的环氧化物开环显示出极佳的区域选择性，可用于合成一系列β-氨基醇。它还显示出在水中合成苯并咪唑衍生物的非常高的催化效率。可以容易地从反应介质中回收催化剂，并且可以重复使用六次而不会显着降低其催化活性和选择性。
• Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for CNS
  申请人：The United States of America as represented by the Department of Health

  公开号：US05739158A1

  公开（公告）日：1998-04-14

  Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychotic disorders, convulsions and parkinsonism. Compounds of particular interest are of the formula ##STR1## wherein R.sup.1 is selected from hydrido, loweralkyl, cycloalkylalkyl of four to six carbon atoms and loweralkenylloweralkyl; wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and loweralkyl; wherein each of R.sup.4 through R.sup.7, R.sup.10 and R.sup.11 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein n is a number selected from four through six; wherein p is a number selected from zero through four; wherein q is a number selected from three through five; wherein A is selected from phenyl, naphthyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.

  描述了用于治疗中枢神经系统疾病，如脑缺血、精神病性障碍、惊厥和帕金森症的某些含氮环杂环烷基氨基芳基化合物。特别感兴趣的化合物具有以下结构：其中R.sup.1从氢代基、低碳原子数的环烷基烷基和低碳烯基烷基中选择；其中R.sup.2和R.sup.3分别独立地从氢代基和低碳烷基中选择；其中R.sup.4至R.sup.7、R.sup.10和R.sup.11分别独立地从氢代基、羟基、低碳烷基、苄基、苯氧基、苄氧基和卤代低碳烷基中选择；其中n是从四到六中选择的数字；其中p是从零到四中选择的数字；其中q是从三到五中选择的数字；其中A从苯基、萘基和噻吩基中选择；其中上述任何A基都可以进一步取代一个或多个取代基，这些取代基独立地从氢代基、羟基、低碳烷基、低碳氧基、卤代基、卤代低碳烷基、氨基、单低碳烷基氨基和双低碳烷基氨基中选择；或其药用盐。
• Hydrophobic amplification of noncovalent organocatalysis
  作者：Christian M. Kleiner、Peter R. Schreiner

  DOI：10.1039/b605850g

  日期：——

  The effects of hydrogen-bonding organocatalysts and water for the acceleration of epoxide openings with a variety of nucleophiles are additive and lead to excellent yields of the catalyzed reactions in water.

  氢键有机催化剂和水对多种亲核试剂促进环氧化物开环反应的效果是相加的，并且在水中催化反应的产率极高。