2-(4-(4-氟苯基)-1H-3-吡唑基)-6-甲基嘧啶 | 607738-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(4-(4-氟苯基)-1H-3-吡唑基)-6-甲基嘧啶
• 英文名称: 2-(4-(4-Fluorophenyl)-1H-pyrazol-3-yl)-6-methylpyridine
• 英文别名: 2-[4-(4-fluorophenyl)-1H-pyrazol-5-yl]-6-methylpyridine
• CAS: 607738-00-1
• 化学式: C₁₅H₁₂FN₃
• 分子量: 253.279
• InChiKey: VJPFFCRCUZQGJL-UHFFFAOYSA-N

物化性质

• 沸点：
  400.1±45.0 °C(Predicted)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  6-甲基-2-吡啶甲酸甲酯 在 盐酸 、 potassium tert-butylate 、 一水合肼 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 118.0h， 生成 2-(4-(4-氟苯基)-1H-3-吡唑基)-6-甲基嘧啶
  参考文献：
  名称：

  Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

  摘要：

  Pyrazole-based inhibitors of the transforming growth factor-beta type I receptor kinase domain (TbetaR-I) are described. Examination of the SAP, in both enzyme- and cell-based in vitro assays resulted in the emergence of two subseries featuring differing selectivity versus p38 MAP kinase. A common binding mode at the active site has been established by successful cocrystallization and X-ray analysis of potent inhibitors with the TbetaR-I receptor kinase domain.

  DOI：

  10.1021/jm0205705

文献信息

• 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME
  申请人：Frequency Therapeutics, Inc.

  公开号：US20180214458A1

  公开（公告）日：2018-08-02

  The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

  本发明涉及1,5-二氢-2H-吡咯-2-酮化合物及其使用方法，用于诱导干/祖细胞支持细胞的自我更新，包括诱导干/祖细胞增殖同时保持子细胞中分化为组织细胞的能力。
• 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME
  申请人：Frequency Therapeutics, Inc.

  公开号：US20200316089A1

  公开（公告）日：2020-10-08

  The present disclosure relates to 1,2-dihydro-3H-pyrazol-3-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

  本公开涉及1,2-二氢-3H-吡唑-3-酮化合物及其使用方法，用于诱导干/祖细胞支持细胞的自我更新，包括诱导干/祖细胞增殖，同时维持子细胞中分化成组织细胞的能力。
• OSTEOGENESIS-PROMOTION ENHANCER AND METHOD OF SCREENING THE SAME
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1632249A1

  公开（公告）日：2006-03-08

  It is an object of the present invention to provide an excellent enhancer for an osteogenesis accelerator that can enhance the activity of BMP as an osteogenesis accelerator. Another object of the present invention is to provide a method of screening for a novel enhancer for an osteogenesis accelerator. The present invention relates to an enhancer for an osteogenesis accelerator, which comprises a compound having a TGF-β selective inhibitory activity as an active ingredient, the enhancer being administered with an osteogenesis accelerator containing BMP as an active ingredient either simultaneously or successively, and to a method of screening for an enhancer for an osteogenesis accelerator, comprising using a TGF-β inhibition as a measure for discovering the enhancer.

  本发明的目的是提供一种优良的成骨促进剂增强剂，它能增强 BMP 作为成骨促进剂的活性。 本发明的另一个目的是提供一种筛选新型成骨促进剂的方法。 本发明涉及一种成骨促进剂的增强剂，它包括一种具有 TGF-β 选择性抑制活性的化合物作为活性成分，该增强剂与含有 BMP 作为活性成分的成骨促进剂同时或先后给药；本发明还涉及一种筛选成骨促进剂的增强剂的方法，包括使用 TGF-β 抑制作用作为发现增强剂的衡量标准。
• 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same
  申请人：Frequency Therapeutics, Inc.

  公开号：US10383881B2

  公开（公告）日：2019-08-20

  The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

  本发明涉及1,5-二氢-2H-吡咯-2-酮化合物以及使用它们诱导干/祖支持细胞自我更新的方法，包括诱导干/祖细胞增殖，同时保持子细胞分化成组织细胞的能力。
• 1H-pyrrole-2,5-dione compounds and methods of using same
  申请人：Frequency Therapeutics, Inc.

  公开号：US11066419B2

  公开（公告）日：2021-07-20

  The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

  本发明涉及 1H-吡咯-2,5-二酮化合物和使用它们诱导干/祖支持细胞自我更新的方法，包括诱导干/祖细胞增殖，同时保持子细胞分化成组织细胞的能力。