6-tert-butyl-5,6,7,8-tetrahydroquinoline | 75414-04-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-tert-butyl-5,6,7,8-tetrahydroquinoline
• 英文别名: 6-t-butyl-5,6,7,8-tetrahydroquinoline
• CAS: 75414-04-9
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: RTZQUWCOCWAQIA-UHFFFAOYSA-N

物化性质

• 沸点：
  272.2±9.0 °C(Predicted)
• 密度：
  0.967±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-特-丁基-4-硝基苯 在 platinum(IV) oxide arsenic(V) oxide 、 硫酸 、 氢气 作用下， 以 三氟乙酸 为溶剂， 生成 6-tert-butyl-5,6,7,8-tetrahydroquinoline
  参考文献：
  名称：

  Hoenel, Michael; Vierhapper, Friedrich W., Journal of the Chemical Society. Perkin transactions I, 1980, p. 1933 - 1939

  摘要：

  DOI：

文献信息

• Substituted Bicyclic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands
  申请人：FRANK Robert

  公开号：US20120115893A1

  公开（公告）日：2012-05-10

  Substituted bicyclic carboxamide and urea compounds corresponding to formula (I) processes for the preparation thereof, pharmaceutical compositions containing these compounds, and a method of using these compounds for the treatment and/or inhibition of pain and other conditions mediated at least in part via the vanilloid receptor 1.

  取代的二环状羧酰胺和尿素化合物，对应于公式(I)，其制备方法，包含这些化合物的药物组合物，以及使用这些化合物治疗和/或抑制至少部分通过香草酸受体1介导的疼痛和其他条件的方法。
• Sequential Amination/Annulation/Aromatization Reaction of Carbonyl Compounds and Propargylamine:  A New One-Pot Approach to Functionalized Pyridines
  作者：Giorgio Abbiati、Antonio Arcadi、Gabriele Bianchi、Sabrina Di Giuseppe、Fabio Marinelli、Elisabetta Rossi

  DOI：10.1021/jo0347260

  日期：2003.9.1

  A general one-pot synthesis of pyridines 4a-t from the reaction of dialkyl acyclic/cyclic ketones 1a-i, methyl, aryl/heteroaryl ketones 1m-r, and aldehydes bearing alpha-hydrogens 1s,t with propargylamine 2 is described. Gold and copper salts are efficient catalysts for the reaction of ketones with 2. The formation of the pyridines 4 is suggested to proceed through the sequential amination of carbonyl

  描述了由二烷基无环/环状酮1a-i，甲基，芳基/杂芳基酮1m-r和带有α-氢1s，t的醛与炔丙基胺2反应的吡啶的一般一锅合成。金盐和铜盐是使酮与2发生反应的有效催化剂。建议通过依次胺化羰基化合物，然后对N-炔丙基亚胺（N-炔丙基二胺）进行区域选择性6-内-挖环化来进行吡啶4的形成。 ）中间体3（5）和芳构化反应。线性多环吡啶4i的制备可以通过使胆甾烷-3-酮1i与2反应来进行，而从胆甾-5-烯-3-酮1j开始已经获得了角型多环吡啶4j。还研究了多环二羰基1k，l与2的反应的选择性。
• Nitrogen and Sulfur-Containing Heterocycle Derivatives
  申请人：Armilli Murty N.

  公开号：US20110269953A1

  公开（公告）日：2011-11-03

  The present invention provides nitrogen and sulfur-containing heterocycle compounds to be used as scaffolds and, in particular, nitrogen and sulfur-containing heterocycle compounds having a thiomorpholine core. The compounds herein described may be useful in treating diseases such as diabetes, obesity, cancer, cardiovascular, Alzheimer's, inflammatory, antidepressant, rheumatoid arthritis, multiple sclerosis, allergic rhinitis, asthma as well as viral and bacterial infections. The compounds herein described may also be useful in treating CNS disorders such as but not limited to Schizophrenia, Alzheimer's disease (AD).

  本发明提供了氮和硫含杂环化合物，用作支架，特别是具有硫代吗啉核心的氮和硫含杂环化合物。所述化合物可用于治疗糖尿病、肥胖症、癌症、心血管疾病、阿尔茨海默病、炎症、抗抑郁症、类风湿性关节炎、多发性硬化症、过敏性鼻炎、哮喘以及病毒和细菌感染等疾病。所述化合物还可用于治疗中枢神经系统疾病，例如但不限于精神分裂症、阿尔茨海默病（AD）。
• NITROGEN AND SULFUR-CONTAINING HETROCYCLE DERIVATIVES
  申请人：Armilli Murty N.

  公开号：US20120041194A1

  公开（公告）日：2012-02-16

  The present invention provides nitrogen and sulfur-containing heterocycle compounds to be used as scaffolds and, in particular, nitrogen and sulfur-containing heterocycle compounds having a thiomorpholine core. The compounds herein described may be useful in treating diseases such as diabetes, obesity, cancer, cardiovascular, Alzheimer's, inflammatory, antidepressant, rheumatoid arthritis, multiple sclerosis, allergic rhinitis, asthma as well as viral and bacterial infections. The compounds herein described may also be useful in treating CNS disorders such as but not limited to Schizophrenia, Alzheimer's disease (AD).

  本发明提供了含氮和硫杂环化合物作为支架使用，特别是具有硫代吗啉核心的含氮和硫杂环化合物。所述化合物可用于治疗糖尿病、肥胖症、癌症、心血管疾病、阿尔茨海默病、炎症、抗抑郁、类风湿性关节炎、多发性硬化症、过敏性鼻炎、哮喘以及病毒和细菌感染等疾病。所述化合物还可用于治疗中枢神经系统疾病，例如但不限于精神分裂症、阿尔茨海默病（AD）。
• Au-complex containing phosphino and imidazolyl moieties as a bi-functional catalyst for one-pot synthesis of pyridine derivatives
  作者：Da Yang、Huan Liu、Dong-Liang Wang、Yong Lu、Xiao-Li Zhao、Ye Liu

  DOI：10.1016/j.molcata.2016.09.008

  日期：2016.12

  The complex of Au-L1 containing imidazolyl ring and the phosphine-ligated-Au moiety was synthesized and applied as the efficient bi-functional catalyst for the one-pot sequential condensation/annulation reaction for the synthesis of pyridine derivatives. It was found that, as for Au-L1, the involved imidazolyl group acted as a Lewis base to catalyze the condensation of carbonyl compounds with propargylamine to form the imino intermediate, and the involved Au+-complex species with alkynophilicity corresponded to the subsequent activation of imino-tailed alkynyl to afford dehydropyridine intermediate. The latter proceeded auto-oxidation reaction to afford the pyridine derivatives. The observed sequential catalysis over Au-L1 proved more efficient than that over the mechanical mixtures of the Au-complex (Au-L2) and N-methylimidazole, because the free N-methylimidazole as an N-containing donor competed with the alkyne substrate to coordinate to Au-center. Moreover, Au-L1 exhibited good generality to a wide range of the substrates for the synthesis of 2,3-fused pyridine derivatives and 2-aryl(heteroaryl)-substituted pyridines. (C) 2016 Elsevier B.V. All rights reserved.