(E)-3-(3-chlorophenyl)-1-cyclopropylprop-2-en-1-one | 268221-60-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(3-chlorophenyl)-1-cyclopropylprop-2-en-1-one
• 英文别名: trans-3-(3 '-chlorophenyl)-1-cyclopropyl-2-propen-1-one；1-cyclopropyl-3-(m-chlorophenyl)prop-2-en-1-one
• CAS: 268221-60-9
• 化学式: C₁₂H₁₁ClO
• 分子量: 206.672
• InChiKey: HBYNZTAHWAWILN-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-3-(3-chlorophenyl)-1-cyclopropylprop-2-en-1-one 在 甲醇 、 sodium tetrahydroborate 作用下， 生成 (E)-3-(3-chlorophenyl)-1-cyclopropylprop-2-en-1-ol
  参考文献：
  名称：

  钌酰胺基配合物催化环烷基乙烯基酮不对称转移加氢成烯丙基醇

  摘要：

  描述了经由不对称转移氢化的对环烷基乙烯基酮的化学选择性1，2-还原。在温和条件下，使用手性二胺钌配合物作为催化剂，同时使用HCOOH-NEt 3共沸物作为氢源和溶剂，还原过程顺利进行。以良好的产率和高达87％的ee获得了广泛的1-环烷基手性烯丙基醇。发现烷基在对映选择性中起重要作用。

  DOI：

  10.1039/c8ob02604a
• 作为产物：
  描述：

  3-氯苯甲醛 生成 (E)-3-(3-chlorophenyl)-1-cyclopropylprop-2-en-1-one
  参考文献：
  名称：

  Pyrrolidine derivatives

  摘要：

  该发明提供了以下结构的化合物：其中R和R'为氢、卤素、烷基、烷氧基、三卤甲基或羟基，或它们一起形成亚甲二氧基；R"为氢或甲基；R"'为氢、烷基、苄基、丙炔基或羟乙基，或其盐。这些化合物可用作压食或兴奋剂。

  公开号：

  US04005103A1

文献信息

• Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides
  申请人：Rohm and Haas Company

  公开号：US06063956A1

  公开（公告）日：2000-05-16

  Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein X is N or CH; Z is O, S or NR.sub.8 ; A is hydrogen, halo, cyano, (C.sub.1 -C.sub.12)alkyl, or (C.sub.1 -C.sub.12)alkoxy; R.sub.1 and R.sub.8 are independently hydrogen or (C.sub.1 -C.sub.4)alkyl; R.sub.2 is hydrogen, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl, halo(C.sub.2 -C.sub.8)alkynyl, aryl, aralkyl, heterocyclic, heterocyclic(C.sub.1 -C.sub.4)alkyl or C(R.sub.10).dbd.N--OR.sub.9 ; R.sub.3 is hydrogen, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl, halo(C.sub.2 -C.sub.8)alkynyl, aryl, aralkyl, aryl(C.sub.3 -C.sub.7)cycloalkyl, heterocyclic or heterocyclic(C.sub.1 -C.sub.4)alkyl; R.sub.4 and R.sub.5 are independently hydrogen, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl, halo(C.sub.2 -C.sub.8)alkynyl, halo, cyano, (C.sub.1 -C.sub.4)alkoxycarbonyl, aryl, aralkyl, aryl(C.sub.3 -C.sub.7)cycloalkyl, heterocyclic or heterocyclic(C.sub.1 -C.sub.4)alkyl; R.sub.6 is hydrogen, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl, halo(C.sub.2 -C.sub.8)alkynyl, halo, cyano, (C.sub.1 -C.sub.4)alkoxycarbonyl, aryl, aralkyl, aryl(C.sub.3 -C.sub.7)cycloalkyl, heterocyclic or heterocyclic(C.sub.1 -C.sub.4)alkyl; R.sub.7 is aryl, aralkyl, heterocyclic or heterocyclic(C.sub.1 -C.sub.4)alkyl; R.sub.9 is hydrogen, (C.sub.1 -C.sub.12,)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl, halo(C.sub.2 -C.sub.8)alkynyl, (C.sub.1 -C.sub.4)alkylcarbonyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, aryl, or aralkyl; and R.sub.10 is hydrogen, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, halo(C.sub.3 -C.sub.7)cycloalkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.2 -C.sub.8)alkynyl, halo(C.sub.2 -C.sub.8)alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic(C.sub.1 -C.sub.4)alkyl.

  具有杀菌和杀虫性质的化合物的化学式为##STR1##其中X为N或CH；Z为O，S或NR.sub.8；A为氢，卤素，氰基，（C.sub.1-C.sub.12）烷基或（C.sub.1-C.sub.12）烷氧基；R.sub.1和R.sub.8分别为氢或（C.sub.1-C.sub.4）烷基；R.sub.2为氢，（C.sub.1-C.sub.12）烷基，卤代（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基，卤代（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.8）烯基，卤代（C.sub.2-C.sub.8）烯基，（C.sub.2-C.sub.8）炔基，卤代（C.sub.2-C.sub.8）炔基，芳基，芳基烷基，杂环，杂环（C.sub.1-C.sub.4）烷基或C（R.sub.10）.dbd.N--OR.sub.9；R.sub.3为氢，（C.sub.1-C.sub.12）烷基，卤代（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基，卤代（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.8）烯基，卤代（C.sub.2-C.sub.8）烯基，（C.sub.2-C.sub.8）炔基，卤代（C.sub.2-C.sub.8）炔基，芳基，芳基烷基，芳基（C.sub.3-C.sub.7）环烷基，杂环或杂环（C.sub.1-C.sub.4）烷基；R.sub.4和R.sub.5分别为氢，（C.sub.1-C.sub.12）烷基，卤代（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基，卤代（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.8）烯基，卤代（C.sub.2-C.sub.8）烯基，（C.sub.2-C.sub.8）炔基，卤代（C.sub.2-C.sub.8）炔基，卤素，氰基，（C.sub.1-C.sub.4）烷氧羰基，芳基，芳基烷基，芳基（C.sub.3-C.sub.7）环烷基，杂环或杂环（C.sub.1-C.sub.4）烷基；R.sub.6为氢，（C.sub.1-C.sub.12）烷基，卤代（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基，卤代（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.8）烯基，卤代（C.sub.2-C.sub.8）烯基，（C.sub.2-C.sub.8）炔基，卤代（C.sub.2-C.sub.8）炔基，卤素，氰基，（C.sub.1-C.sub.4）烷氧羰基，芳基，芳基烷基，芳基（C.sub.3-C.sub.7）环烷基，杂环或杂环（C.sub.1-C.sub.4）烷基；R.sub.7为芳基，芳基烷基，杂环或杂环（C.sub.1-C.sub.4）烷基；R.sub.9为氢，（C.sub.1-C.sub.12）烷基，卤代（C.sub.1-C.sub.12）烷基，（C.sub.2-C.sub.8）烯基，卤代（C.sub.2-C.sub.8）烯基，（C.sub.2-C.sub.8）炔基，卤代（C.sub.2-C.sub.8）炔基，（C.sub.1-C.sub.4）烷基羰基，（C.sub.1-C.sub.4）烷氧羰基，芳基或芳基烷基；R.sub.10为氢，（C.sub.1-C.sub.12）烷基，卤代（C.sub.1-C.sub.12）烷基，（C.sub.3-C.sub.7）环烷基，卤代（C.sub.3-C.sub.7）环烷基，（C.sub.2-C.sub.8）烯基，卤代（C.sub.2-C.sub.8）烯基，（C.sub.2-C.sub.8）炔基，卤代（C.sub.2-C.sub.8）炔基，芳基，芳基烷基，杂环或杂环（C.sub.1-C.sub.4）烷基。
• Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1026151A1

  公开（公告）日：2000-08-09

  Compounds with fungicidal and insecticidal properties having formula wherein X is N or CH; Z is O, S or NR8; A is hydrogen, halo, cyano, (C1-C12)alkyl, or (C1-C12)alkoxy; R1 and R8 are independently hydrogen or (C1-C4)alkyl; R2 is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, hererocyclic, hererocyclic(C1-C4)alkyl or C(R10)=N-OR9; R3 is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, aryl(C3-C7)cycloalkyl, heterocyclic or heterocyclic(C1-C4)alkyl; R4 and R5 are independently hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, halo, cyano, (C1-C4)alkoxycarbonyl, aryl, aralkyl, aryl(C3-C7)cycloalkyl, heterocyclic or hererocyclic(C1-C4)alkyl; R6 is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, halo, cyano, (C1-C4)alkoxycarbonyl, aryl, aralkyl, aryl(C3-C7)cycloalkyl, heterocyclic or hererocyclic(C1-C4)alkyl; R7 is aryl, aralkyl, heterocyclic or heterocyclic(C1-C4)alkyl; R9 is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, (C1-C4)alkylcarbonyl, (C1-C4)alkoxycarbonyl, aryl, or aralkyl; and R10 is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic(C1-C4)alkyl.

  具有杀菌和杀虫特性的化合物，其式为 其中 X 是 N 或 CH；Z 是 O、S 或 NR8；A 是氢、卤代、氰基、(C1-C12)烷基或(C1-C12)烷氧基；R1 和 R8 独立地是氢或(C1-C4)烷基；R2 是氢、(C1-C12)烷基、卤代(C1-C12)烷基、(C3-C7)环烷基、卤代(C3-C7)环烷基、(C2-C8)烯基、卤代(C2-C8)烯基、(C2-C8)炔基、卤代(C2-C8)炔基、芳基、芳烷基、异环烷基、异环(C1-C4)烷基或 C(R10)=N-OR9；R3 是氢、(C1-C12)烷基、卤代(C1-C12)烷基、(C3-C7)环烷基、卤代(C3-C7)环烷基、(C2-C8)烯基、卤代(C2-C8)烯基、(C2-C8)炔基、卤代(C2-C8)炔基、芳基、芳烷基、芳基(C3-C7)环烷基、杂环或杂环(C1-C4)烷基；R4 和 R5 独立地为氢、(C1-C12)烷基、卤代(C1-C12)烷基、(C3-C7)环烷基、卤代(C3-C7)环烷基、(C2-C8)烯基、卤代(C2-C8)烯基、(C2-C8)炔基、卤代(C2-C8)炔基、卤代、氰基、(C1-C4)烷氧基羰基、芳基、芳烷基、芳基(C3-C7)环烷基、杂环或杂环(C1-C4)烷基；R6 是氢、(C1-C12)烷基、卤代(C1-C12)烷基、(C3-C7)环烷基、卤代(C3-C7)环烷基、(C2-C8)烯基、卤代(C2-C8)烯基、(C2-C8)炔基、卤代(C2-C8)炔基、卤代、氰基、(C1-C4)烷氧基羰基、芳基、芳烷基、芳基(C3-C7)环烷基、杂环或异环(C1-C4)烷基；R7 是芳基、芳烷基、杂环基或杂环（C1-C4）烷基；R9 是氢、(C1-C12)烷基、卤代(C1-C12)烷基、(C2-C8)烯基、卤代(C2-C8)烯基、(C2-C8)炔基、卤代(C2-C8)炔基、(C1-C4)烷基羰基、(C1-C4)烷氧基羰基、芳基或芳烷基；R10 是氢、(C1-C12)烷基、卤代(C1-C12)烷基、(C3-C7)环烷基、卤代(C3-C7)环烷基、(C2-C8)烯基、卤代(C2-C8)烯基、(C2-C8)炔基、卤代(C2-C8)炔基、芳基、芳烷基、杂环基或杂环(C1-C4)烷基。
• US6063956A
  申请人：——

  公开号：US6063956A

  公开（公告）日：2000-05-16
• Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes
  作者：Sensheng Liu、Peng Cui、Juan Wang、Haifeng Zhou、Qixing Liu、Jinliang Lv

  DOI：10.1039/c8ob02604a

  日期：——

  A chemoselective 1,2-reduction of cycloalkyl vinyl ketones via asymmetric transfer hydrogenation is described. The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH–NEt3 azeotrope as both a hydrogen source and solvent under mild conditions. A wide range of 1-cycloalkyl chiral allylic alcohols were obtained in good yields and up to 87% ee. It was found that

  描述了经由不对称转移氢化的对环烷基乙烯基酮的化学选择性1，2-还原。在温和条件下，使用手性二胺钌配合物作为催化剂，同时使用HCOOH-NEt 3共沸物作为氢源和溶剂，还原过程顺利进行。以良好的产率和高达87％的ee获得了广泛的1-环烷基手性烯丙基醇。发现烷基在对映选择性中起重要作用。
• Pyrrolidine derivatives
  申请人：Societe Anonyme dite: Hexachimie

  公开号：US04005103A1

  公开（公告）日：1977-01-25

  The invention provides compounds of formula ##STR1## wherein R and R' are hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxy or they together form methylenedioxy, R" is hydrogen or methyl, and R"' is hydrogen, alkyl, benzyl, propargyl or hydroxyethyl, or salts thereof. The compounds are useful as anorexigenic or analeptic agents.

  该发明提供了以下结构的化合物：其中R和R'为氢、卤素、烷基、烷氧基、三卤甲基或羟基，或它们一起形成亚甲二氧基；R"为氢或甲基；R"'为氢、烷基、苄基、丙炔基或羟乙基，或其盐。这些化合物可用作压食或兴奋剂。