3-Oxo-3-(4-phenylphenyl)propanal | 84864-25-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Oxo-3-(4-phenylphenyl)propanal
• CAS: 84864-25-5
• 化学式: C₁₅H₁₂O₂
• mdl: MFCD09996477
• 分子量: 224.259
• InChiKey: AYWBLKYTVMQJMC-UHFFFAOYSA-N

物化性质

• 沸点：
  388.4±25.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Oxo-3-(4-phenylphenyl)propanal 在 三乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.5h， 生成 1-benzyl-4-biphenyl-4-yl-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid tert-butylamide
  参考文献：
  名称：

  Highly Substituted Pyrrolidinones and Pyridones by 4-CR/2-CR Sequence

  摘要：

  By combining a Ugi four-component reaction of isocyanides, phosphonoacetic acids, primary amines, and glyoxals or alternatively 3-keto aldehydes with a subsequent Wittig ring-closing reaction (using the Horner/Wadsworth/Emmons variant (HWE)), highly substituted 5-oxo-2,5dihydro-1H-pyrrole-2-carboxylic acid amides and 6-oxo-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid amides can be assembled, respectively. The corresponding tandem of a Passerini reaction on 3-keto aldehydes and subsequent Wittig ring closure does not afford the expected six-membered 6-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid amides but instead leads to the formation of 4-oxo-pent-2-enoic acid amides via an elimination route.

  DOI：

  10.1021/ol035787n
• 作为产物：
  描述：

  联苯单乙酮 、 甲酸乙酯 在 sodium methylate 作用下， 以 四氢呋喃 为溶剂， 生成 3-Oxo-3-(4-phenylphenyl)propanal
  参考文献：
  名称：

  乙烯基异羟肟酸的合成，化学和生物学特性：5-脂氧合酶和IL-1生物合成的双重抑制剂。

  摘要：

  制备了乙烯基异羟肟酸（3-（N-羟基-N-烷基氨基）-2-丙烯-1-酮，VHA）作为抗炎剂。描述了这些相对未开发的化合物的合成，化学性质和体外生物学活性。通过将适当的N-取代的羟胺与以下三种试剂中的任何一种缩合来制备VHA：1,3-二羰基化合物（方法A）；乙烯基酰胺（方法B）；或炔烃（方法C）。VHA以一种或多种互变异构体的形式存在于溶液中，每种互变异构体的相对比例取决于VHA的结构，溶剂和pH。VHA会经历异羟肟酸和乙烯基酰胺类的某些典型反应。VHA在体外具有5-脂氧合酶和IL-1生物合成抑制剂的活性，不会抑制花生四烯酸级联反应的其他酶。ESR研究表明，它们可通过还原活性位点铁来抑制大豆1 15型脂氧合酶。

  DOI：

  10.1021/jm00100a011

文献信息

• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• [EN] SAMPLE PRECONCENTRATION TUBES WITH SOL-GEL SURFACE COATINGS AND/OR SOL-GEL MONOLITHIC BEDS<br/>[FR] TUBES DE PRECONCENTRATION D'ECHANTILLON A REVETEMENTS DE SURFACE SOL-GEL ET/OU LITS MONOLITHIQUES SOL-GEL
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2002055986A2

  公开（公告）日：2002-07-18

  A method of preconcentrating trace analytes is accomplished by extracting polar and non-polar analytes through a sol-gel coating. The sol-gel coating is either disposed on the inner surface of a capillary tube or disposed within the tube as a monolithic bed.