5,8-dioxadodecane-3,10-diol | 74262-25-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,8-dioxadodecane-3,10-diol
• 英文别名: 1-[2-(2-Hydroxybutoxy)ethoxy]butan-2-ol
• CAS: 74262-25-2
• 化学式: C₁₀H₂₂O₄
• 分子量: 206.282
• InChiKey: OWDMXJFGPMXOFD-UHFFFAOYSA-N

物化性质

• 沸点：
  130 °C(Press: 10 Torr)
• 密度：
  1.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2'-thiodiethanoyl chloride 、 5,8-dioxadodecane-3,10-diol 以 苯 为溶剂， 以20%的产率得到8,15-diethyl-1,7,10,13-tetraoxa-4-thiacyclopentadecane-2,6-dione
  参考文献：
  名称：

  Synthesis of diethyl, di-n-octyl, and mono- and dicyclohexano macrocyclic polyether-diester ligands

  摘要：

  DOI：

  10.1021/jo01306a003
• 作为产物：
  描述：

  1,2-环氧丁烷 、 乙二醇 在 sodium 作用下， 以66%的产率得到5,8-dioxadodecane-3,10-diol
  参考文献：
  名称：

  Synthesis of diethyl, di-n-octyl, and mono- and dicyclohexano macrocyclic polyether-diester ligands

  摘要：

  DOI：

  10.1021/jo01306a003

文献信息

• Photochromic Polymer
  申请人：Evans Richard Alexander

  公开号：US20140042377A1

  公开（公告）日：2014-02-13

  A photochromic polymer comprising at least two photochromic moieties linked by a straight or branched chain polymer selected from the group consisting of poly(C2 to C4 alkylene oxide), poly[C 1 to C 10 alkoxy substituted (C 2 to C 4 alkylene oxide)] and poly[C 1 to C- 15 acyloxy substituted (C 2 to C 4 alkylene oxide)].

  一种光致变色聚合物，包括至少两个光致变色基团，这些基团通过直链或支链聚合物链接，所述聚合物选自以下组合：聚（C2到C4烷氧基）烷，聚[C1到C10烷氧基取代（C2到C4烷氧基）]和聚[C1到C-15酰氧取代（C2到C4烷氧基）]。
• Chain-extended polydimethylsiloxane vinylic crosslinkers and uses thereof
  申请人：Novartis AG

  公开号：US10301451B2

  公开（公告）日：2019-05-28

  The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.

  本发明提供了一种链延聚二有机硅氧烷乙烯基交联剂，它包括(1)一条聚合物链，该聚合物链包括至少两个聚二有机硅氧烷段和每对聚二有机硅氧烷段之间的一个亲水连接体，其中每个聚二有机硅氧烷包括至少5个连续排列的二甲基硅氧烷单元，其中亲水连接体是具有至少两个(甲基)丙烯酰胺分子的二价基；(2) 两个末端(甲基)丙烯酰基，其中链延聚二有机硅氧烷乙烯基交联剂的平均分子量至少约为 1500 道尔顿。本发明还涉及一种硅酮水凝胶隐形眼镜，它包含由本发明的链延聚二有机硅氧烷乙烯基交联剂衍生的重复单元。此外，本发明还提供了一种使用包含本发明的链延聚二有机硅氧烷乙烯基交联剂的镜片成型配方来制造硅氧烷水凝胶隐形眼镜的方法。
• Silicone hydrogel contact lenses
  申请人：Alcon Inc.

  公开号：US10866344B2

  公开（公告）日：2020-12-15

  The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

  本发明一般涉及具有相对较高透氧率、相对较高平衡水含量和相对较低弹性模量的固有可湿性硅水凝胶隐形眼镜。本发明还涉及制作这种固有可湿性硅水凝胶隐形眼镜的方法。
• Method for producing silicone hydrogel contact lenses
  申请人：Alcon Inc.

  公开号：US11254075B2

  公开（公告）日：2022-02-22

  The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprises the combination of using a hydrophilic (meth)acrylamido monomer as one of major polymerizable components in a lens formulation for cast-molding of contact lenses, adding a post-curing treatment step which involves heating molds with molded lenses therewithin in an oven at a post-curing temperature higher than the curing temperature and under nitrogen gas flow at a higher flow rate, and using ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.

  本发明提供了一种隐形眼镜制造方法，包括一种以相对高效和一致的方式从半模中取出未加工的模制硅水凝胶隐形眼镜的工艺。本发明的方法包括以下组合：使用亲水性（甲基）丙烯酰胺单体作为镜片配方中的主要可聚合成分之一，用于隐形眼镜的浇铸成型；添加后固化处理步骤，包括在后固化温度高于固化温度的烘箱中，并在较高流速的氮气流下加热装有模塑镜片的模具；以及使用超声波振动能量进行脱膜。本发明的方法可在生产环境中轻松实施，以提高产量。
• Method for making silicone hydrogel contact lenses
  申请人：Alcon Inc.

  公开号：US11427685B2

  公开（公告）日：2022-08-30

  The invention provides a method for making silicone hydrogel contact lenses. The method of the invention is characterized by using an organic solvent as a processing-aid tool for controlling lens diameter without significantly affecting lens equilibrium water content during cast-molding of soft contact lenses from a polymerizable composition. By adjusting the weight percentage of the organic solvent in a polymerizable composition for making SiHy contact lenses, one can adjust lens diameter of produced SiHy lenses to meet target without affecting adversely the lens properties.

  本发明提供了一种硅水凝胶隐形眼镜的制作方法。本发明方法的特点是在用可聚合组合物浇铸成型软性隐形眼镜的过程中，使用有机溶剂作为控制镜片直径的加工辅助工具，而不会明显影响镜片的平衡含水量。通过调整有机溶剂在用于制造硅水隐形眼镜的可聚合组合物中的重量百分比，可以调整所生产的硅水隐形眼镜的镜片直径以达到目标，而不会对镜片性能产生不利影响。