4-chloro-2-(4-(trifluoromethyl)phenyl)pyridine | 659730-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-chloro-2-(4-(trifluoromethyl)phenyl)pyridine
• 英文别名: 4-Chloro-2-[4-(trifluoromethyl)phenyl]pyridine
• CAS: 659730-49-1
• 化学式: C₁₂H₇ClF₃N
• 分子量: 257.642
• InChiKey: UFUVIXUEKQZCSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-2-(4-(trifluoromethyl)phenyl)pyridine 在 四(三苯基膦)钯 、 三甲基氰硅烷 、 双氧水 、 sodium methylate 、 potassium carbonate 、 溶剂黄146 、 肼 、 二甲氨基甲酰氯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 114.0h， 生成
  参考文献：
  名称：

  2-PHENYL-6-AZOLYLPYRIDINE-BASED LIGAND AND GROUP VIII TRANSITION METAL COMPLEX

  摘要：

  一种基于2-苯基-6-氮杂吡啶的配体由以下公式（I）表示：其中，X代表氮或C—R10；R1、R2、R3、R4、R5、R6、R7、R8和R10独立地代表氢、卤素、氰基、氨基、可选择取代的芳基、可选择取代的杂环芳基、硫酸根、—COOH、烷氧基、羰基、C1-C10卤代烷基、C1-C12烷基、C2-C10烯基、C2-C10炔基、C3-C20环烷基、C3-C20环烯基、C1-C20杂环烷基或C1-C20杂环烯基；R9代表氢或碱金属。

  公开号：

  US20130018189A1
• 作为产物：
  描述：

  2-{4-(三氟甲基)苯基}-4-吡啶胺 在 亚硝酸特丁酯 、 copper dichloride 作用下， 以 乙腈 为溶剂， 反应 2.67h， 生成 4-chloro-2-(4-(trifluoromethyl)phenyl)pyridine
  参考文献：
  名称：

  [EN] VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
  [FR] LIGANDS DE RECEPTEUR VANILLOIDE ET LEUR UTILISATION DANS CERTAINS TRAITEMENTS

  摘要：

  公开号：

  WO2005033105A3

文献信息

• [EN] NOVEL HETEROCYCLIC COMPOUNDS AS ANTIMALARIAL AGENTS<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES UTILES EN TANT QU'AGENTS ANTIPALUDIQUES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2015028989A1

  公开（公告）日：2015-03-05

  The invention relates to novel heterocyclic compounds of the Formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the Formula I and especially their use as medicaments to treat or prevent malaria infections or to treat or prevent other protozoal diseases like sleeping sickness, Chagas disease, amebiasis, giardiasis, trichomoniasis, toxoplasmosis, and leishmaniasis.

  本发明涉及式I的新颖杂环化合物。本发明还涉及包括制备化合物的方法、包含式I的一个或多个化合物的药物组合物，尤其是它们作为药物用于治疗或预防疟疾感染或治疗或预防其他原虫疾病，如昏睡病、查加斯病、阿米巴病、贾第虫病、滴虫病、弓形虫病和利什曼病。
• Chemoselective Chromium(II)-Catalyzed Cross-Coupling Reactions of Dichlorinated Heteroaromatics with Functionalized Aryl Grignard Reagents
  作者：Andreas K. Steib、Olesya M. Kuzmina、Sarah Fernandez、Sushant Malhotra、Paul Knochel

  DOI：10.1002/chem.201405275

  日期：2015.1.26

  dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated in this transformation. Previously challenging substrates, quinolines and isoquinolines, participate in the selective Cr‐catalyzed cross‐coupling in cyclopentyl methyl ether (CPME) as the solvent. The effective purging of Cr salts is demonstrated

  氯化铬（II）在室温下催化二氯吡啶与一系列功能化（杂）芳族格氏试剂的化学选择性交叉偶联反应。在这种转化过程中，对酯和缩醛等官能团的耐受性良好。以前具有挑战性的底物喹啉和异喹啉在溶剂中以环戊基甲基醚（CPME）参与选择性的Cr催化交叉偶联。通过使用各种固体载体可有效清除Cr盐。
• TBAF-Catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds
  作者：Frédéric Louërat、Heather Tye、Spencer Napier、Michael Garrigou、Mark Whittaker、Philippe C. Gros

  DOI：10.1039/c0ob00710b

  日期：——

  The concomitant use of silver oxide and catalytic amount of TBAF allowed the efficient and chemoselective coupling of readily available 4-chloro- and 4-methyl-2-trimethyl-silyl-pyridines with heteroaromatic and aromatic halides. Based on control experiments, a mechanism involving the formation of a pyridylsilver intermediate and TBAF recycling is postulated.

  银氧化物和催化量的TBAF并用，使得容易获得的4-氯和4-甲基-2-三甲基硅基吡啶与杂芳香族和芳香族卤化物的高效且化学选择性偶联成为可能。基于对照实验，推测了一个涉及吡啶银中间体形成及TBAF再循环的机制。
• [EN] VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS<br/>[FR] LIGANDS DE RECEPTEUR VANILLOIDE ET LEUR UTILISATION DANS DES TRAITEMENTS
  申请人：AMGEN INC

  公开号：WO2004014871A1

  公开（公告）日：2004-02-19

  Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  含有通用结构和组成的化合物及其组合物，用于治疗急性、炎症性和神经痛、牙痛、普通头痛、偏头痛、集群性头痛、混合性血管和非血管综合症、紧张性头痛、普通炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠病、炎症性眼病、炎症性或不稳定的膀胱疾病、牛皮癣、带有炎症成分的皮肤病、慢性炎症状况、炎症性疼痛及相关的高敏性和触痛，神经痛及相关的高敏性和触痛、糖尿病神经病疼痛、烧伤后神经痛、交感神经维持的疼痛、去神经症候群、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸道、泌尿生殖系统、胃肠道或血管区域的内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、普通胃肠疾病、胃溃疡、十二指肠溃疡、腹泻、坏死性剂引起的胃病变、毛发生长、血管运动或过敏性鼻炎、支气管疾病或膀胱疾病。
• Vanilloid receptor ligands and their use in treatments
  申请人：——

  公开号：US20040082780A1

  公开（公告）日：2004-04-29

  Compounds having the general structure 1 and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  具有一般结构1的化合物及其组成物，用于治疗急性、炎症和神经痛、牙痛、普通头痛、偏头痛、集群头痛、混合血管和非血管综合症、紧张性头痛、普通炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠病、炎症性眼疾、炎症性或不稳定的膀胱疾病、牛皮癣、具有炎症成分的皮肤病、慢性炎症状况、炎症性疼痛及相关的高敏感性和触痛、神经痛及相关的高敏感性和触痛、糖尿病神经病痛、烧灼性疼痛、交感神经维持性疼痛、去神经症候群、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、胃肠或血管区域的内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、普通胃肠障碍、胃溃疡、十二指肠溃疡、腹泻、坏死剂诱导的胃病变、毛发生长、血管运动或过敏性鼻炎、支气管疾病或膀胱疾病。