3t-(3-methoxy-4-benzyloxy-phenyl)-2-cyano-acrylic acid | 65004-73-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3t-(3-methoxy-4-benzyloxy-phenyl)-2-cyano-acrylic acid
• 英文别名: 3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-acrylic acid；3t-(3-Methoxy-4-benzyloxy-phenyl)-2-cyan-acrylsaeure；3-(4-Benzyloxy-3-methoxy-phenyl)-2-cyan-acrylsaeure；3-Methoxy-4-benzyloxy-benzylidencyanessigsaeure；3-Methoxy-4-benzyloxy-α-cyan-zimtsaeure；(E)-2-cyano-3-(3-methoxy-4-phenylmethoxyphenyl)prop-2-enoic acid
• CAS: 65004-73-1
• 化学式: C₁₈H₁₅NO₄
• 分子量: 309.321
• InChiKey: NYIFCLVWUIQWSE-OQLLNIDSSA-N

物化性质

• 熔点：
  203-204 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• 沸点：
  510.5±50.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  79.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3t-(3-methoxy-4-benzyloxy-phenyl)-2-cyano-acrylic acid 、 硼氢化钠 生成 3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-propionic acid
  参考文献：
  名称：

  KANO S.; YOKOMATSU T.; SHIBUFA S., CHEM. AND PHARM. BULL. , 1977, 25, NO 9, 2401-2409

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-acrylic acid ethyl ester 在 氢氧化钾 作用下， 生成 3t-(3-methoxy-4-benzyloxy-phenyl)-2-cyano-acrylic acid
  参考文献：
  名称：

  Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms

  摘要：

  Purpose: To determine the correlation between the tomographic features and the visual functions of eyes with diabetic macular edema. Methods: Optical coherence tomographic (OCT) images and multifocal electroretinograms were obtained from 45 eyes of 25 patients with diabetic macular edema and from 21 eyes of 21 normal subjects. Results: The OCT images showed cystoid macular edema in 18 eyes and diffuse retinal swelling without cystoid edema in the other 27 eyes. The fovea was significantly thicker in eyes with cystoid macular edema and in those with diffuse retinal swelling than in normal eyes. The fovea of eyes with cystoid edema was significantly thicker than the fovea of eyes with diffuse swelling. The best-corrected visual acuity and the electrical response density from the macular area were significantly reduced in eyes with diabetic macular edema, particularly in those with cystoid edema. The best-corrected visual acuity and macular response density of the multifocal ERGs were inversely correlated, and the implicit times were directly correlated with foveal thickness. Conclusion: The visual acuity was correlated significantly with morphological changes revealed by OCT and with multifocal ERGs. The combination of OCT and multifocal ERGs may provide objective criteria for the evaluation and assessment of diabetic macular edema.

  DOI：

  10.1007/s004170000238

文献信息

• 153. The constituents of natural phenolic resins. Part X. Structure of l-matairesinol dimethyl ether and observations on the condensation of reactive methylene groups with O-methyleugenol oxide
  作者：Robert D. Haworth、John R. Atkinson

  DOI：10.1039/jr9380000797

  日期：——
• RADIOGRAPHIC ELEMENT
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0555465A1

  公开（公告）日：1993-08-18
• US5215876A
  申请人：——

  公开号：US5215876A

  公开（公告）日：1993-06-01
• [EN] RADIOGRAPHIC ELEMENT
  申请人：EASTMAN KODAK COMPANY

  公开号：WO1993005444A1

  公开（公告）日：1993-03-18

  (EN) A radiographic element comprises a polyester support having double sided silver halide emulsion layers. An ultraviolet light absorbing methine compound is copolymerized with the support and is present in an amount sufficient to reduce the average percent transmission of ultraviolet light over the range of wavelength of from about 350 nm to about 395 nm to less than about 25 percent, and whereby the percent transmittance of said element is at least about 55 percent at a wavelength of about 410 nm for an element thickness of about 0.007 inch.(FR) Un élément radiographique comprend un support en polyester ayant des couches d'émission en halogénure d'argent double face. Un composé de méthine absorbant la lumière ultraviolette est copolymérisé avec le support et est présent en une quantité suffisante pour réduire le pourcentage moyen de transmission de lumière ultraviolette dans la plage de longueurs d'ondes allant de 350 nm environ 395 nm environ jusqu'à réduire ce pourcentage à 25 % environ, le pourcentage du facteur de transmission dudit élément étant au moins de 55 % environ à une longueur d'onde d'environ 410 nm pour une épaisseur d'élément d'environ 0,007 pouce.
• Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms
  作者：Shuichi Yamamoto、Teiko Yamamoto、Masanori Hayashi、Shinobu Takeuchi

  DOI：10.1007/s004170000238

  日期：2001.2

  Purpose: To determine the correlation between the tomographic features and the visual functions of eyes with diabetic macular edema. Methods: Optical coherence tomographic (OCT) images and multifocal electroretinograms were obtained from 45 eyes of 25 patients with diabetic macular edema and from 21 eyes of 21 normal subjects. Results: The OCT images showed cystoid macular edema in 18 eyes and diffuse retinal swelling without cystoid edema in the other 27 eyes. The fovea was significantly thicker in eyes with cystoid macular edema and in those with diffuse retinal swelling than in normal eyes. The fovea of eyes with cystoid edema was significantly thicker than the fovea of eyes with diffuse swelling. The best-corrected visual acuity and the electrical response density from the macular area were significantly reduced in eyes with diabetic macular edema, particularly in those with cystoid edema. The best-corrected visual acuity and macular response density of the multifocal ERGs were inversely correlated, and the implicit times were directly correlated with foveal thickness. Conclusion: The visual acuity was correlated significantly with morphological changes revealed by OCT and with multifocal ERGs. The combination of OCT and multifocal ERGs may provide objective criteria for the evaluation and assessment of diabetic macular edema.