3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-propionic acid | 65004-76-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-propionic acid
• 英文别名: β-(3-Methoxy-4-benzyloxy-phenyl)-α-cyan-propionsaeure；3-Methoxy-4-benzyloxy-α-cyan-hydrozimtsaeure；3-(4-Benzyloxy-3-methoxy-phenyl)-2-cyan-propionsaeure；3-Methoxy-4-benzyloxy-benzylcyanessigsaeure；2-cyano-3-(3-methoxy-4-phenylmethoxyphenyl)propanoic acid
• CAS: 65004-76-4
• 化学式: C₁₈H₁₇NO₄
• 分子量: 311.337
• InChiKey: VSEXFSRTOBFLSP-UHFFFAOYSA-N

物化性质

• 熔点：
  125-126.5 °C
• 沸点：
  512.8±50.0 °C(Predicted)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  79.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-propionic acid 在 吡啶 作用下， 生成 3-(4-benzyloxy-3-methoxy-phenyl)-propionitrile
  参考文献：
  名称：

  Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms

  摘要：

  Purpose: To determine the correlation between the tomographic features and the visual functions of eyes with diabetic macular edema. Methods: Optical coherence tomographic (OCT) images and multifocal electroretinograms were obtained from 45 eyes of 25 patients with diabetic macular edema and from 21 eyes of 21 normal subjects. Results: The OCT images showed cystoid macular edema in 18 eyes and diffuse retinal swelling without cystoid edema in the other 27 eyes. The fovea was significantly thicker in eyes with cystoid macular edema and in those with diffuse retinal swelling than in normal eyes. The fovea of eyes with cystoid edema was significantly thicker than the fovea of eyes with diffuse swelling. The best-corrected visual acuity and the electrical response density from the macular area were significantly reduced in eyes with diabetic macular edema, particularly in those with cystoid edema. The best-corrected visual acuity and macular response density of the multifocal ERGs were inversely correlated, and the implicit times were directly correlated with foveal thickness. Conclusion: The visual acuity was correlated significantly with morphological changes revealed by OCT and with multifocal ERGs. The combination of OCT and multifocal ERGs may provide objective criteria for the evaluation and assessment of diabetic macular edema.

  DOI：

  10.1007/s004170000238
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium amalgam 、 水 作用下， 生成 3-(4-benzyloxy-3-methoxy-phenyl)-2-cyano-propionic acid
  参考文献：
  名称：

  Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms

  摘要：

  Purpose: To determine the correlation between the tomographic features and the visual functions of eyes with diabetic macular edema. Methods: Optical coherence tomographic (OCT) images and multifocal electroretinograms were obtained from 45 eyes of 25 patients with diabetic macular edema and from 21 eyes of 21 normal subjects. Results: The OCT images showed cystoid macular edema in 18 eyes and diffuse retinal swelling without cystoid edema in the other 27 eyes. The fovea was significantly thicker in eyes with cystoid macular edema and in those with diffuse retinal swelling than in normal eyes. The fovea of eyes with cystoid edema was significantly thicker than the fovea of eyes with diffuse swelling. The best-corrected visual acuity and the electrical response density from the macular area were significantly reduced in eyes with diabetic macular edema, particularly in those with cystoid edema. The best-corrected visual acuity and macular response density of the multifocal ERGs were inversely correlated, and the implicit times were directly correlated with foveal thickness. Conclusion: The visual acuity was correlated significantly with morphological changes revealed by OCT and with multifocal ERGs. The combination of OCT and multifocal ERGs may provide objective criteria for the evaluation and assessment of diabetic macular edema.

  DOI：

  10.1007/s004170000238

文献信息

• KANO S.; YOKOMATSU T.; SHIBUFA S., CHEM. AND PHARM. BULL. <CPBT-AL>, 1977, 25, NO 9, 2401-2409
  作者：KANO S.、 YOKOMATSU T.、 SHIBUFA S.

  DOI：——

  日期：——