4-(2-Bromo-4-fluorophenoxy)pyridine | 1016707-67-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-Bromo-4-fluorophenoxy)pyridine
• CAS: 1016707-67-7
• 化学式: C₁₁H₇BrFNO
• mdl: MFCD09929853
• 分子量: 268.085
• InChiKey: SJVJOTCFTZGJQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-Bromo-4-fluorophenoxy)pyridine 在 palladium diacetate 、 potassium carbonate 、 1,3-双(2,6-二异丙基苯基)氯化咪唑鎓 作用下， 以 乙二醇二甲醚 为溶剂， 以85%的产率得到C₁₁H₆FNO
  参考文献：
  名称：

  Facile synthesis of benzo[4,5]furo[3,2-c]pyridines via palladium-catalyzed intramolecular Heck reaction

  摘要：

  The heating of 4-chloropyridine with 2-bromophenol in either neat or DME as solvent gives rise to 2-bromophenoxy pyridines, which were treated with Pd(OAc)(2) and various ligands to afford functionalized benzo[4,5]furo[3,2-c]pyridines. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.063
• 作为产物：
  描述：

  4-氯吡啶 、 2-溴-4-氟苯酚 反应 24.0h， 生成 4-(2-Bromo-4-fluorophenoxy)pyridine
  参考文献：
  名称：

  Facile synthesis of benzo[4,5]furo[3,2-c]pyridines via palladium-catalyzed intramolecular Heck reaction

  摘要：

  The heating of 4-chloropyridine with 2-bromophenol in either neat or DME as solvent gives rise to 2-bromophenoxy pyridines, which were treated with Pd(OAc)(2) and various ligands to afford functionalized benzo[4,5]furo[3,2-c]pyridines. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.063

文献信息

• Facile synthesis of benzo[4,5]furo[3,2-c]pyridines via palladium-catalyzed intramolecular Heck reaction
  作者：Woo Sub Yoon、Su Jung Lee、Seung Kyu Kang、Deok-Chan Ha、Jae Du Ha

  DOI：10.1016/j.tetlet.2009.05.063

  日期：2009.8

  The heating of 4-chloropyridine with 2-bromophenol in either neat or DME as solvent gives rise to 2-bromophenoxy pyridines, which were treated with Pd(OAc)(2) and various ligands to afford functionalized benzo[4,5]furo[3,2-c]pyridines. (C) 2009 Elsevier Ltd. All rights reserved.