(2-methylphenyl)diphenylphosphine sulfide | 20676-80-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-methylphenyl)diphenylphosphine sulfide
• 英文别名: diphenyl(o-tolyl)phosphine sulfide；diphenyl-o-tolylphosphine sulfide；Diphenyl-(o-tolyl)-phosphinsulfid；Diphenyl-o-tolyl-thiophosphinoxid；(2-Methylphenyl)-diphenyl-sulfanylidene-lambda5-phosphane；(2-methylphenyl)-diphenyl-sulfanylidene-λ5-phosphane
• CAS: 20676-80-6
• 化学式: C₁₉H₁₇PS
• 分子量: 308.384
• InChiKey: BIJAPGNFJICUQH-UHFFFAOYSA-N

物化性质

• 沸点：
  444.7±38.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三苯基瞵硫 在 四甲基乙二胺 、 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 以26%的产率得到(2-methylphenyl)diphenylphosphine sulfide
  参考文献：
  名称：

  硫代磷酰基化合物的苯基邻位锂化和烷基α位锂化

  摘要：

  将二苯基膦硫基硫基化合物邻位锂化，将烷基二苯基硫醚硫化物进行α-锂化，并使所得的硫代硫基化合物反应，得到相应的-和α-取代的产物。

  DOI：

  10.1016/s0040-4039(00)99936-2

文献信息

• Pd-Catalyzed P-C Cross-Coupling of Aryl Bromides and Triflates with Hydroxymethylphosphine Sulfide Derivatives
  作者：Hidetoshi Ohta、Qian Xue、Minoru Hayashi

  DOI：10.1002/ejoc.201701706

  日期：2018.2.14

  A powerful method for versatile phosphine synthesis: The P–C coupling of hydroxymethylphosphine sulfide derivatives with various aryl bromides and triflates to yield triarylphosphine sulfides has been developed. The new method was successfully applied to the sequential triple coupling of an orthogonally protected precursor to give an unsymmetrically substituted triarylphosphine sulfide.

  通用膦合成的有效方法：已开发了羟甲基膦硫化物衍生物与各种芳基溴化物和三氟甲磺酸酯进行P–C偶联以产生三芳基膦硫化物的方法。该新方法已成功应用于正交保护的前体的顺序三重偶联，从而得到不对称取代的三芳基膦硫化物。
• Radical Phosphination of Organic Halides and Alkyl Imidazole-1-carbothioates
  作者：Akinori Sato、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1021/ja058783h

  日期：2006.4.5

  Taking advantage of a radical-based methodology, mild and chemoselective phosphination reactions of organic halide and alkyl imidazole-1-carbothioates have been developed. The mild reaction conditions allow labile functional groups to survive during the reaction.
• Pd-Catalyzed P–C Cross-Coupling Reactions for Versatile Triarylphosphine Synthesis
  作者：Minoru Hayashi、Takashi Matsuura、Ippei Tanaka、Hidetoshi Ohta、Yutaka Watanabe

  DOI：10.1021/ol303448j

  日期：2013.2.1

  Practical and versatile syntheses of tertiary phosphine derivatives have been achieved by palladium-catalyzed deformylative P-C cross-coupling reactions of hydroxymethylphosphine derivatives. Sequential couplings of orthogonally protected precursors provide a simple and practical route toward a variety of tertiary phosphine derivatives having aryl substituents in any combination.
• YOSHIFUJI, MASAAKI;ISHIZUKA, TADAO;CHOI, YOON, JUNG;INAMOTO, NAOKI, TETRAHEDRON LETT., 1984, 25, N 5, 553-556
  作者：YOSHIFUJI, MASAAKI、ISHIZUKA, TADAO、CHOI, YOON, JUNG、INAMOTO, NAOKI

  DOI：——

  日期：——
• ANTI-CANCER GOLD COMPOUNDS
  申请人：Royal Melbourne Institute of Technology

  公开号：US20220204538A1

  公开（公告）日：2022-06-30

  A compound according to Formula (I), or a pharmaceutically acceptable salt thereof: wherein R 1 and R 2 are each independently selected from optionally substituted C 1-6 -alkyl and optionally substituted aryl; R 3 , R 4 , R 5 , and R 6 are each independently selected from the group consisting of H, halo, optionally substituted C 1-6 -alkyl, and optionally substituted C 1-6 alkoxy; and R 7 is a phosphorus containing moiety, wherein a phosphorus atom is bonded to Au.