3-(4-ethylphenyl)-2-methylacrylic acid | 773112-19-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(4-ethylphenyl)-2-methylacrylic acid
• 英文别名: Methyl 3-(4-ethylphenyl)acrylic acid；3-(4-ethylphenyl)-2-methylprop-2-enoic acid
• CAS: 773112-19-9
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: GNPPLPJNYSGQGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-ethylphenyl)-2-methylacrylic acid 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 80.0 ℃ 、1.01 MPa 条件下， 反应 36.0h， 生成 6-ethyl-2-methyl-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

  摘要：

  RXR alpha represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXR alpha and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXR alpha (tRXR alpha) with the p85 alpha regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXR alpha-dependent AKT activation. A new compound 30 was identified to have improved biological activity. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.012
• 作为产物：
  描述：

  丙酸酐 、 4-乙基苯甲醛 在 potassium carbonate 作用下， 反应 12.08h， 以41%的产率得到3-(4-ethylphenyl)-2-methylacrylic acid
  参考文献：
  名称：

  Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

  摘要：

  RXR alpha represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXR alpha and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXR alpha (tRXR alpha) with the p85 alpha regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXR alpha-dependent AKT activation. A new compound 30 was identified to have improved biological activity. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.012

文献信息

• (METH)ACRYLIC COPOLYMER, RESIN COMPOSITION, MOLDED BODY OF SAME, AND METHOD FOR PRODUCING MOLDED BODY
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP3517571A1

  公开（公告）日：2019-07-31

  Provided is a resin composition which is capable of forming a molded body that has excellent surface hardness, transparency, hue and weather resistance, while exhibiting excellent wet heat resistance. A resin composition which contains a (meth)acrylic copolymer (A) and a polycarbonate-based resin (B), and wherein: the (meth)acrylic copolymer (A) contains an aromatic (meth)acrylate unit (al), a methyl (meth)acrylate unit (a2) and a (meth)acrylate unit (a3) represented by formula (1); the mass ratio (al)/(a2) is from 5/95 to 85/15; the content of the unit (a3) is 0.1-10 parts by mass relative to 100 parts by mass of the total of the units (a1) and (a2); and the unit (a1) is different from the unit (a3).

  本发明提供了一种树脂组合物，该树脂组合物能够形成表面硬度、透明度、色调和耐候性极佳的模塑体，同时还具有极佳的耐湿热性。一种树脂组合物，它含有(甲基)丙烯酸共聚物(A)和聚碳酸酯基树脂(B)，其中：(甲基)丙烯酸共聚物(A)含有由式(1)表示的芳香族(甲基)丙烯酸酯单元(al)、(甲基)丙烯酸甲酯单元(a2)和(甲基)丙烯酸酯单元(a3)；质量比(al)/(a2)为 5/95 至 85/15；单元(a3)的含量为 0.相对于单元(a1)和(a2)总质量的 100 质量份，单元(a1)的含量为 0.1-10 质量份；单元(a1)不同于单元(a3)。
• Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation
  作者：Zhi-Gang Wang、Liqun Chen、Jiebo Chen、Jian-Feng Zheng、Weiwei Gao、Zhiping Zeng、Hu Zhou、Xiao-kun Zhang、Pei-Qiang Huang、Ying Su

  DOI：10.1016/j.ejmech.2013.01.012

  日期：2013.4

  RXR alpha represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXR alpha and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXR alpha (tRXR alpha) with the p85 alpha regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXR alpha-dependent AKT activation. A new compound 30 was identified to have improved biological activity. (C) 2013 Elsevier Masson SAS. All rights reserved.