2,2-diethoxybutanenitrile | 56011-13-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-diethoxybutanenitrile
• 英文别名: 2,2-diethoxy-butyronitrile；2,2-Diaethoxy-butyronitril；Bis-ethoxybutyronitril
• CAS: 56011-13-3
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: URVAQRRJJYOYGN-UHFFFAOYSA-N

物化性质

• 沸点：
  62-63 °C(Press: 10 Torr)
• 密度：
  0.9113 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  42.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-diethoxybutanenitrile 在 lithium aluminium tetrahydride 、 水 、 溶剂黄146 作用下， 生成 2,2-diethoxybutanal
  参考文献：
  名称：

  Babler, James H., Synthetic Communications, 1989, vol. 19, # 3and4, p. 355 - 358

  摘要：

  DOI：
• 作为产物：
  描述：

  丙酮腈 、 原丙酸三乙酯 反应 20.0h， 生成 2,2-diethoxybutanenitrile
  参考文献：
  名称：

  A facile route to α-imino acetals and the corresponding monoacetal derivatives of α-diketones with complete regiochemical control.

  摘要：

  DOI：

  10.1016/s0040-4039(00)96589-4

文献信息

• Doornbos,T.; Peer,H.G., Recueil des Travaux Chimiques des Pays-Bas, 1972, vol. 91, p. 711 - 728
  作者：Doornbos,T.、Peer,H.G.

  DOI：——

  日期：——
• Laparoscopic Surgery for Endometriosis: A Long Term Follow-Up
  作者：Makoto Tokushige、Hiroshi Suginami、Fumiaki Taniguchi、Yuki Kitaoka

  DOI：10.1111/j.1447-0756.2000.tb01350.x

  日期：2000.12

  AbstractObjective: To investigate if complete resolution of endometriosis by laparoscopic surgery is beneficial to postoperative fecundity, dysmenorrhea and dyspareunia.Design: An observational comparative study on the outcome of laparoscopic surgery.Patients: Laparoscopically‐treated symptomatic women with endometriosis (total n = 236); complete (n = 185) and incomplete (n = 51) surgery groups.Measurements: Postoperative fecundity and symptom reduction.Results: With whole populations, no surgical completeness‐related difference was observed in cumulative pregnancy rates during the postoperative days 0–400 (cycle fecundity rate = 0.0319). Further accumulation of pregnant cases was followed in the complete surgery group (final cumulative pregnancy rate = 80%), but not in the counterpart group (p = 0.003). The similar result was obtained when only r‐AFS classification stages III and IV were compared (p = 0.007). No r‐AFS stage‐related difference was observed in cumulative pregnancy rates when only patients of complete surgery were selected for comparison. The surgery reduced dysmenorrhea (84.7%) and dyspareunia (80.0%).Conclusions: Laparoscopic conservative surgery for endometriosis, especially when it is complete, increases fecundity and reduces disease‐related symptoms, such as dysmenorrhea and dyspareunia.
• Synthetic Methods and Reactions; 114¹. General Procedure for the Conversion of Acetals and Ketone Acetals into 2-Alkoxyalkanenitriles using Cyanotritnethylsilane
  作者：Stephan Kirchmeyer、Alfred Mertens、Massoud Arvanaghi、George A. Olah

  DOI：10.1055/s-1983-30402

  日期：——
• A facile route to α-imino acetals and the corresponding monoacetal derivatives of α-diketones with complete regiochemical control.
  作者：James H. Babler、Charles J. Marcuccilli

  DOI：10.1016/s0040-4039(00)96589-4

  日期：1987.1
• BABLER, JAMES H., SYNTH. COMMUN., 19,(1989) N-4, C. 355-358
  作者：BABLER, JAMES H.

  DOI：——

  日期：——