1,2-dimethoxy-3,4-dimethylbenzene | 248252-69-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-dimethoxy-3,4-dimethylbenzene
• 英文别名: 3,4-dimethylveratrole；1,2-dimethoxy-3,4-dimethyl-benzene；1,2-Dimethoxy-3,4-dimethyl-benzol；3.4-Dimethyl-veratrol
• CAS: 248252-69-9
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: MOWKJTWPZXQWTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-dimethoxy-3,4-dimethylbenzene 在 硝酸 作用下， 以 乙酸酐 、 溶剂黄146 为溶剂， 以76%的产率得到1,2-dimethoxy-3,4-dimethyl-5-nitrobenzene
  参考文献：
  名称：

  有机合成中的过渡金属配合物，第54部分。改进的抗生素生物碱卡巴霉素A和B的总合成

  摘要：

  据报道，使用会合铁介导的一锅结构的咔唑骨架通过空气中的氧化环化，咔唑抗生素咔唑霉素A和咔唑霉素的总合成得到了显着改善。

  DOI：

  10.1016/s0040-4039(99)01418-5
• 作为产物：
  描述：

  2,3-二甲氧基甲苯 在 N-溴代丁二酰亚胺(NBS) 、 正丁基锂 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 3.0h， 生成 1,2-dimethoxy-3,4-dimethylbenzene
  参考文献：
  名称：

  有机合成中的过渡金属配合物，第54部分。改进的抗生素生物碱卡巴霉素A和B的总合成

  摘要：

  据报道，使用会合铁介导的一锅结构的咔唑骨架通过空气中的氧化环化，咔唑抗生素咔唑霉素A和咔唑霉素的总合成得到了显着改善。

  DOI：

  10.1016/s0040-4039(99)01418-5

文献信息

• 18F-LABELED PRECURSOR OF PET RADIOACTIVE MEDICAL SUPPLIES, AND PREPARATION METHOD THEREOF
  申请人：Chi Dae-Yoon

  公开号：US20140194620A1

  公开（公告）日：2014-07-10

  The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18 F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

  本发明涉及正电子发射断层扫描（PET）放射性医疗用品的前体、其制备方法及应用，更具体地，涉及一种具有四价有机盐离基的前体、其制备方法，以及通过引入 18 F并通过单步骤使用相同物质在短时间内高放射化学产率制备所需PET放射性医疗用品的方法。本发明的具有四价有机盐离基的前体可以将已知的复杂多步制备放射性医疗用品简化为单步骤，因为不需要过量的相转移催化剂，可以节省生产成本，促进反应后化合物的分离，并实现快速反应速度。这些特点适用于通过自动合成系统大规模生产PET放射性医疗用品。
• [EN] NEW MACROLIDES AND THEIR USE<br/>[FR] NOUVEAUX MACROLIDES ET LEUR UTILISATION
  申请人：BASILEA PHARMACEUTICA AG

  公开号：WO2009106419A1

  公开（公告）日：2009-09-03

  The invention relates to macrolide compounds of formula (I),the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with anti-inflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.

  本发明涉及公式(I)的大环内酯化合物，以及所述化合物作为药物的应用，特别是用于治疗或预防炎性和过敏性疾病，包含所述化合物的药物组合物，以及它们的制备过程。本发明特别涉及主要通过抑制磷酸二酯酶4（PDE4）介导抗炎活性的大环内酯化合物，这使得它们可用于治疗和/或预防诸如慢性阻塞性肺病（COPD）、哮喘、类风湿性关节炎、特应性皮炎、炎症性肠病或增殖性疾病，例如癌症等炎性和过敏性疾病。
• Palladium-Catalyzed, <i>tert-</i> Butyllithium-Mediated Dimerization of Aryl Halides and Its Application in the Atropselective Total Synthesis of Mastigophorene A
  作者：Jeffrey Buter、Dorus Heijnen、Carlos Vila、Valentín Hornillos、Edwin Otten、Massimo Giannerini、Adriaan J. Minnaard、Ben L. Feringa

  DOI：10.1002/anie.201510328

  日期：2016.3.7

  A palladium‐catalyzed direct synthesis of symmetric biaryl compounds from aryl halides in the presence of tBuLi is described. In situ lithium–halogen exchange generates the corresponding aryl lithium reagent, which undergoes a homocoupling reaction with a second molecule of the aryl halide in the presence of the palladium catalyst (1 mol %). The reaction takes place at room temperature, is fast (1 h)

  描述了在t BuLi存在下钯催化芳基卤化物直接合成对称联芳基化合物的方法。原位锂-卤素交换生成相应的芳基锂试剂，该试剂在钯催化剂（1摩尔％）存在下与第二个芳基卤分子进行均偶联反应。反应在室温下进行，反应快速（1小时），并以良好至极好的收率得到相应的联芳基化合物。该方法的应用已证明了高效的igo草烯A的不对称全合成。由于催化剂诱导的远程点对轴手性转移，手性联芳基轴的抗选择性为9：1。
• A Direct Palladium-Catalyzed Route to Selectively Substituted Carbazoles through Sequential CC and CN Bond Formation: Synthesis of Carbazomycin A
  作者：Nicola Della Ca'、Giovanni Sassi、Marta Catellani

  DOI：10.1002/adsc.200800421

  日期：2008.10.6

  one-pot procedure for the catalytic preparation of the biologically interesting class of carbazoles. The new procedure is based on the combined catalysis of palladium and norbornene starting from o-substituted iodoarenes and N-sulfonylated or N-acetylated o-bromoanilines. A well-known member of this class, carbazomycin A, has been successfully prepared.

  本文提供了一种合成简单的一锅法，用于催化制备生物学上有趣的咔唑类化合物。该新方法是基于钯和降冰片烯从邻取代的碘芳烃和N-磺酰化或N-乙酰化的o-溴代苯胺开始的联合催化。已经成功制备了此类的一个著名成员，卡巴霉素A。
• Macrolides Useful Against Inflammatory and Allergic Diseases
  申请人：Kellenberger Johannes Laurenz

  公开号：US20100120706A1

  公开（公告）日：2010-05-13

  Macrolide compounds of formula I: with PDF4 inhibiting activity are described, wherein R1 is a residue —Y—X-Q; Y is S, SO or SO 2 ; X is a bond or a linear group consisting of hydrogen atoms and with up to 9 atoms selected from C, N, O and/or S, of which up to 2 atoms can be N and one atom can be O or S, one carbon atom can appear as a CO group and the sulphur atom can appear as an SO2 group and two adjacent C atoms can be present as —CH═CH— or —C≡C— and which group X is unsubstituted or is substituted with —COO—W or —CONH—W; Q is a residue —V-A1-L-A2-W or, if X does not represent a bond, may also be —NR6R7; V is a divalent aromatic or heterocyclic group; W is aryl or heterocyclyl; or in a group —V-A1-L-A2-W, wherein at least one of the groups A1; L or A2 is present, can also be a monovalent substituted or unsubstituted, saturated or unsaturated linear group with up to 5 atoms consisting of C, N, O and/or S of which one carbon can appear as a CO group one sulphur atom can appear as an SO2 group, A1, A2 are independently of each other either absent or a C 1 -C 4 alkylene group; L is —O—, —S—, —SO2-, —NH—, —CO—, —(CO)O—, —O(OC)—, —(CO)NH—, —NH(CO)—, —(SO 2 )NH—, —HN(SO 2 )—, —HN(CO)NH—, —O(CO)NH—, —NH(CO)O—, or can also be absent if A1 and/or A2 are present; R2 is hydrogen and R3 is and OR4 or R2, R3 taken together form a C═O group; R4 is hydrogen or an saturated or unsaturated aliphatic group with 1 to 6 carbon atoms; R6, R7 are independently selected from aryl; aralkyl; heterocyclyl and heterocyclylalkyl; and one of R6 and R7 can also be a group -L-W; and * indicates a chiral centre which is in the (R) or (S) form.

  本文描述了具有PDF4抑制活性的公式I的大环内酯化合物，其中R1是一个残基-Y-X-Q; Y是S，SO或SO2; X是一个键或由氢原子组成的线性基团，其中可选的原子有C，N，O和/或S，其中最多有2个原子可以是N，一个原子可以是O或S，一个碳原子可以出现为CO基团，硫原子可以出现为SO2基团，两个相邻的C原子可以出现为-CH═CH-或-C≡C-，并且该基团X未被取代或被取代为-COO-W或CONH-W; Q是一个残基-V-A1-L-A2-W或，如果X不表示键，则也可以是-NR6R7; V是一个双价芳香或杂环基团; W是芳基或杂环基团; 或在一个组-V-A1-L-A2-W中，其中至少有一个A1；L或A2也可能是一个单价取代或未取代的饱和或不饱和线性基团，其中最多有5个原子，包括C，N，O和/或S，其中一个碳可以出现为CO基团，一个硫原子可以出现为SO2基团，A1，A2彼此独立地不存在或是C1-C4烷基基团; L是-O-，-S-，-SO2-，-NH-，-CO-，-(CO)O-，-O(OC)-，-(CO)NH-，-NH(CO)-，-(SO2)NH-，-HN(SO2)-，-HN(CO)NH-，-O(CO)NH-，-NH(CO)O-，或者如果A1和/或A2存在，则L也可以不存在; R2是氢，R3是OR4或R2，R3共同形成一个C═O基团; R4是氢或含有1到6个碳原子的饱和或不饱和脂肪基团; R6，R7独立地选自芳基；芳基烷基；杂环基和杂环基烷基；其中R6和R7中的一个也可以是一个-L-W基团; *表示一个手性中心，它是(R)或(S)形式。