4-hydroxy-2-(4-nitro-phenyl)-quinoline-3-carboxylic acid ethyl ester | 855762-93-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-hydroxy-2-(4-nitro-phenyl)-quinoline-3-carboxylic acid ethyl ester
• 英文别名: 4-Hydroxy-2-(4-nitro-phenyl)-chinolin-3-carbonsaeure-aethylester；2-(4-Nitrophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester；ethyl 2-(4-nitrophenyl)-4-oxo-1H-quinoline-3-carboxylate
• CAS: 855762-93-5
• 化学式: C₁₈H₁₄N₂O₅
• 分子量: 338.32
• InChiKey: HULZJWFXZZEQIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-hydroxy-2-(4-nitro-phenyl)-quinoline-3-carboxylic acid ethyl ester 在 sodium hydroxide 作用下， 生成 4-hydroxy-2-(4-nitro-phenyl)-quinoline-3-carboxylic acid
  参考文献：
  名称：

  Synthesis of 2-Phenyl-4-chloroquinolines¹

  摘要：

  DOI：

  10.1021/ja01211a042
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 4-hydroxy-2-(4-nitro-phenyl)-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  102.亚氨基氯化物。第三部分 苯胺基亚氨基氯化物与苏马二酸乙酯的反应

  摘要：

  DOI：

  10.1039/jr9360000428

文献信息

• [EN] TETRACYCLIC IMMUNOMODULATORY COMPOUNDS<br/>[FR] COMPOSES IMMUNOMODULATEURS TETRACYCLIQUES
  申请人：ACTIVE BIOTECH AB

  公开号：WO2004055014A1

  公开（公告）日：2004-07-01

  The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

  本发明涉及新型杂环化合物、其制备方法、含有它们的组合物以及用于临床治疗可能从免疫调节中获益的医疗条件的方法和用途，包括类风湿性关节炎、多发性硬化症、糖尿病、哮喘、移植、系统性红斑狼疮和银屑病等。更具体地，本发明涉及新型杂环化合物，它们是CD80拮抗剂，能够抑制CD80和CD28之间的相互作用。
• Tetracylic immunomodulatory compounds
  申请人：Matthews Richard Lan

  公开号：US20060035919A1

  公开（公告）日：2006-02-16

  The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly, the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

  本发明涉及新型杂环化合物，其制备方法，含有它们的组合物，以及用于医疗条件的临床治疗的方法和用途，这些条件可能从免疫调节中受益，包括类风湿性关节炎，多发性硬化症，糖尿病，哮喘，移植，系统性红斑狼疮和牛皮癣。更具体地说，本发明涉及新型杂环化合物，它们是CD80拮抗剂，能够抑制CD80和CD28之间的相互作用。
• Tetracyclic immunomodulatory compounds
  申请人：Active Biotech AB

  公开号：US07674906B2

  公开（公告）日：2010-03-09

  The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly, the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.

  本发明涉及新型杂环化合物、其制备方法、含有它们的组合物，以及用于临床治疗可能受益于免疫调节的医疗情况的方法和用途，包括类风湿性关节炎、多发性硬化症、糖尿病、哮喘、移植、系统性红斑狼疮和银屑病。更具体地说，本发明涉及新型杂环化合物，它们是CD80拮抗剂，能够抑制CD80和CD28之间的相互作用。
• 102. Imidochlorides. Part III. Reaction of anilide imidochlorides and ethyl sodiomalonate
  作者：R. C. Shah、V. R. Heeramaneck

  DOI：10.1039/jr9360000428

  日期：——
• TETRACYCLIC IMMUNOMODULATORY COMPOUNDS
  申请人：Active Biotech AB

  公开号：EP1572689B1

  公开（公告）日：2009-03-11