2-(全氟-N-己基)乙醛二甲基乙缩醛 | 142502-76-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(全氟-N-己基)乙醛二甲基乙缩醛
• 英文名称: 2-tridecafluorohexyl-1,1-dimethoxyethane
• 英文别名: 2-(Perfluoro-n-hexyl)acetaldehyde Dimethyl Acetal；1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8,8-dimethoxyoctane
• CAS: 142502-76-9
• 化学式: C₁₀H₉F₁₃O₂
• 分子量: 408.159
• InChiKey: BYPGRUVLTPMKIS-UHFFFAOYSA-N

物化性质

• 沸点：
  71°C 14mm
• 密度：
  1,534 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  15

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为产物：
  描述：

  1-溴-1-(全氟己基)乙烯 在 氢氧化钾 、 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 生成 2-(全氟-N-己基)乙醛二甲基乙缩醛
  参考文献：
  名称：

  Synthesis of vicinal perfluoroalkyl enol ethers

  摘要：

  A convenient preparation of vicinal perfluoroalkyl enol ethers, by the action of alcohols on 1-bromo-1-perfluoroalkylethylenes to the presence of potassium hydroxide, is described. Some aspects of their reactivity are reported. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2004.07.001

文献信息

• Novel aerosol formulation containing a polar fluorinated molecule
  申请人：——

  公开号：US20030194378A1

  公开（公告）日：2003-10-16

  The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.

  本发明涉及一种用于吸入的稳定药用气溶胶制剂。该制剂含有一种活性物质、一种气溶胶推进剂、一种极性氟化分子和一种赋形剂。优选的推进剂是 HFA 134a 或 HFA 227 或它们的混合物。
• Synthése de fluoroalkyl éthanl : RFCH2CHO
  作者：Ph. Laurent、H. Blancou、A. Commeyras

  DOI：10.1016/s0040-4039(00)92222-6

  日期：1992.4

  Aldehydes RFCH2CHO (R(F) is a linear perfluoroalkyl chain) have been obtained in the addition reaction of R(F)I to vinyl acetate in the presence of zinc. RFCH2CHIOAc is formed as an intermediate in the course of the reaction. Under appropriate conditions, RFCH2CHO and its acylal or acetal derivatives are obtained in good yields.
• NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE
  申请人：AstraZeneca AB

  公开号：EP1303258A1

  公开（公告）日：2003-04-23
• [EN] NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE<br/>[FR] NOUVELLE PREPARATION EN AEROSOL CONTENANT UNE MOLECULE FLUOREE POLAIRE
  申请人：ASTRAZENECA AB

  公开号：WO2002003958A1

  公开（公告）日：2002-01-17

  The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.
• Synthesis of vicinal perfluoroalkyl enol ethers
  作者：H. Zoghlami、I. Chehidi、M.M. Chaabouni、A. Baklouti

  DOI：10.1016/j.jfluchem.2004.07.001

  日期：2004.12

  A convenient preparation of vicinal perfluoroalkyl enol ethers, by the action of alcohols on 1-bromo-1-perfluoroalkylethylenes to the presence of potassium hydroxide, is described. Some aspects of their reactivity are reported. (C) 2004 Elsevier B.V. All rights reserved.