3-methylguanosine | 68768-32-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 3-methylguanosine
• 英文别名: 3-methyl-guanosine；3-Methylguanosin；2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-methylpurin-6-one
• CAS: 68768-32-1
• 化学式: C₁₁H₁₅N₅O₅
• 分子量: 297.271
• InChiKey: BHIRVHIKZMXXQN-KQYNXXCUSA-N

物化性质

• 熔点：
  180-183 °C
• 沸点：
  737.4±70.0 °C(Predicted)
• 密度：
  2.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-methylguanosine 在 hydroxide 、 氢气 作用下， 生成 3-甲基鸟嘌呤
  参考文献：
  名称：

  Itaya, Taisuke; Matsumoto, Hiroo; Watanabe, Tomoko, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 6, p. 2339 - 2347

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-5-(methylamino)imidazole-4-carboxamide 在 氨 、 sodium acetate 、 sodium hydride 作用下， 以 溶剂黄146 为溶剂， 反应 44.0h， 生成 3-methylguanosine
  参考文献：
  名称：

  Itaya, Taisuke; Matsumoto, Hiroo; Watanabe, Tomoko, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 6, p. 2339 - 2347

  摘要：

  DOI：

文献信息

• A simple synthesis of 3-β-<scp>D</scp>-ribofuranosylwye and the stability of its glycosidic bond
  作者：Taisuke Itaya、Tomoko Watanabe、Hiroo Matsumoto

  DOI：10.1039/c39800001158

  日期：——

  Treatment of 5-(methylamino)-1-β-D-ribofuranosylimidazole-4-carboxamide (3) with CNBr followed by cyclization and reaction with bromoacetone gave 3-β-D-ribofuranosylwye (2) whose glycosidic bond was cleaved rapidly in acidic or alkaline solution, but was fairly stable at pH 5–8·5 at 37 °C.

  用CNBr处理5-（甲基氨基）-1 - β - D-呋喃核糖嘧啶-4-羧酰胺（3），然后环化并与溴丙酮反应，得到3- β - D-呋喃呋喃糖基wye（2），其糖苷键在酸性条件下迅速断裂或碱性溶液，但在37°C的pH 5–8·5下相当稳定。
• Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids
  申请人：Direvo Biotech AG

  公开号：EP1281757A1

  公开（公告）日：2003-02-05

  Methods and kit for producing recombinant chimeric polynucleotides comprising: forming heteroduplices with single-stranded, partially heterologous source nucleic acids which contain at least one marker nucleotide, introducing single-stranded nicks at sites of the marker nucleotides, and starting synthesis of single-stranded nucleic acids at the nick sites, the non-nicked strand serving as template.

  用于生产重组嵌合多核苷酸的方法和试剂盒，包括：与含有至少一个标记核苷酸的单链部分异源核酸形成异源复合物，在标记核苷酸位点引入单链缺口，并在缺口位点开始合成单链核酸，非缺口链作为模板。
• Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
  申请人：Baker F. Brenda

  公开号：US20050037370A1

  公开（公告）日：2005-02-17

  Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers has a modified base for binding to an adenine or guanine base in the opposite strand. Oligonucleotide/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein the oligomer has a modified base for binding to an adenine or guanine base in the opposite strand.

  提供了包含第一和第二寡聚体的寡聚体组合物，其中第一寡聚体的至少一部分能够与第二寡聚体的至少一部分杂交，第一寡聚体的至少一部分与所选靶核酸互补并能够与所选靶核酸杂交，第一或第二寡聚体的至少一种具有修饰碱基，用于与相反链中的腺嘌呤或鸟嘌呤碱基结合。还提供了寡核苷酸/蛋白质组合物，该组合物包含与所选靶核酸互补并能与之杂交的寡聚体，以及至少一种包含 RNA 诱导沉默复合体（RISC）至少一部分的蛋白质，其中寡聚体具有与相反链中腺嘌呤或鸟嘌呤碱基结合的修饰碱基。
• A novel route to 3-methylguanosine by chemical degradation of wyosine
  作者：Jerzy Boryski、Wojciech Folkman、Bo·enna Golankiewicz

  DOI：10.1016/s0040-4039(00)80445-1

  日期：1988.1
• Itaya, Taisuke; Harada, Tsunehiro, Heterocycles, 1984, vol. 21, # 2, p. 748
  作者：Itaya, Taisuke、Harada, Tsunehiro

  DOI：——

  日期：——