1-tert-butoxy-2,2,4-trimethyl-pentan-3-one | 61478-23-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-tert-butoxy-2,2,4-trimethyl-pentan-3-one
• 英文别名: 1-tert-Butoxy-2,2,4-trimethylpentan-3-one；2,2,4-trimethyl-1-[(2-methylpropan-2-yl)oxy]pentan-3-one
• CAS: 61478-23-7
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: FQUOIALALTZHRP-UHFFFAOYSA-N

物化性质

• 沸点：
  248.8±13.0 °C(Predicted)
• 密度：
  0.868±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  碘代三甲硅烷 、 1-tert-butoxy-2,2,4-trimethyl-pentan-3-one 以 氘代氯仿 为溶剂， 生成 2,2,4-Trimethyl-1-trimethylsilanyloxy-pentan-3-one
  参考文献：
  名称：

  Quantitative dealkylation of alkyl ethers via treatment with trimethylsilyl iodide. A new method for ether hydrolysis

  摘要：

  DOI：

  10.1021/jo00443a033
• 作为产物：
  描述：

  2,2,4-三甲基-1,3-戊二醇 、 异丁烯 生成 1-tert-butoxy-2,2,4-trimethyl-pentan-3-one
  参考文献：
  名称：

  Oxidation of ethers via hydride abstraction: a new procedure for selective oxidation of primary, secondary diols at the secondary position

  摘要：

  DOI：

  10.1021/ja00440a102

文献信息

• METHODS FOR LIGATION AND USES THEREOF
  申请人：Ploegh Hidde L.

  公开号：US20110321183A1

  公开（公告）日：2011-12-29

  The present invention relates to methods for ligation. The invention provides novel reagents and methods for ligating an acyl donor compound with an acyl acceptor compound. Provided acyl donor compounds comprise a transamidase recognition sequence that allows ligation with a nucleophilic acyl acceptor in the presence of transamidase. The invention further provides kits comprising acyl donor compounds and optionally comprising other reagents for ligation.
• Quantitative dealkylation of alkyl ethers via treatment with trimethylsilyl iodide. A new method for ether hydrolysis
  作者：Michael E. Jung、Mark A. Lyster

  DOI：10.1021/jo00443a033

  日期：1977.11
• Oxidation of ethers via hydride abstraction: a new procedure for selective oxidation of primary, secondary diols at the secondary position
  作者：Michael E. Jung、Laurine M. Speltz

  DOI：10.1021/ja00440a102

  日期：1976.11