5,6-Dimethyldecane-5,6-diol | 97795-56-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,6-Dimethyldecane-5,6-diol
• CAS: 97795-56-7
• 化学式: C₁₂H₂₆O₂
• 分子量: 202.337
• InChiKey: XSLFJDUVYGPEQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-己酮 在 三氢化钐 、 三甲基氯硅烷 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 0.25h， 生成 5,6-Dimethyldecane-5,6-diol
  参考文献：
  名称：

  钐和三甲基氯硅烷/碘化钠体系在乙腈中生成和反应碘化钐等价物

  摘要：

  在环境条件下，从金属钐和 Me3SiCl/Nal 试剂在乙腈中生成碘化钐 (II) 等价物。α-卤代羰基化合物的脱卤和酮的还原偶联成功地通过使用在乙腈中产生的钐（II）物种进行。

  DOI：

  10.1246/cl.1992.2431

文献信息

• Generation and Reaction of Samarium(II) Iodide Equivalent from Samarium and Chlorotrimethylsilane/Sodium Iodide System in Acetonitrile
  作者：Noriyuki Akane、Yoshinori Kanagawa、Yutaka Nishiyama、Yasutaka Ishii

  DOI：10.1246/cl.1992.2431

  日期：1992.12

  Samarium(II) iodide equivalent was generated from metallic samarium and Me3SiCl/Nal reagent in acetonitrile under ambient conditions. Dehalogenation of α-halocarbonyl compounds and reductive coupling of ketones were successfully carried out by the use of the samarium(II) species, thus generated, in acetonitrile.

  在环境条件下，从金属钐和 Me3SiCl/Nal 试剂在乙腈中生成碘化钐 (II) 等价物。α-卤代羰基化合物的脱卤和酮的还原偶联成功地通过使用在乙腈中产生的钐（II）物种进行。
• Reactions of methyl and allyl praseodymium derivatives with ketones
  作者：G. A. Gailyunas、R. Kh. Biktimirov、Yu. B. Monakov、G. A. Tolstikov

  DOI：10.1007/bf00953055

  日期：1985.12
• GAJLYUKAS, G. A.;BIKTIMIROV, R. X.;MONAKOV, YU. B.;TOLSTIKOV, G. A., IZV. AN CCCP. CEP. XIM., 1985, N 12, 2830-2831
  作者：GAJLYUKAS, G. A.、BIKTIMIROV, R. X.、MONAKOV, YU. B.、TOLSTIKOV, G. A.

  DOI：——

  日期：——
• New Generation Method for a Samarium(II) Equivalent: Me3SiX (X = Br and I)/Sm-Assisted Intermolecular Carbon-Carbon Bond Forming Reactions of Carbonyl Compounds
  作者：Noriyuki Akane、Tadashi Hatano、Hiroko Kusui、Yutaka Nishiyama、Yasutaka Ishii

  DOI：10.1021/jo00104a056

  日期：1994.12

  Samarium(II) species can be efficiently generated in situ from a reaction between elemental samarium and chlorotrimethylsilane (Me(3)SiCl)/sodium iodide (NaI) reagent or bromotrimethylsilane (Me(3)SiBr) in acetonitrile. The reductive coupling reaction of carbonyl compounds was achieved by the action of Sm(II) reagent thus generated from Sm/Me(3)SiCl/NaI or Sm/Me(3)SiBr to give the corresponding pinacol products in moderate to high yields. The samarium(II) reagent induced the intermolecular coupling reaction of alpha,beta-unsaturated esters with carbonyl compounds or imines followed by intramolecular cyclization to form the corresponding gamma-lactones or gamma-lactams in moderate yields. The reaction of alpha-bromo esters with carbonyl compounds using the Sm (II) species, generated from the Sm/Me(3)SiX system, led to the corresponding beta-hydroxy esters in 52-95% yields.