毒理性
识别和使用：元素钐是一种菱形银色金属。它用作中子吸收剂、激光晶体掺杂剂、冶金研究以及永久磁铁。人类暴露和毒性：钐金属如果通过皮肤吸收、吞咽或吸入可能有害。它可能导致皮肤、呼吸道和眼睛刺激。动物研究：技术磁性材料越来越多地用于开发磁性保持牙齿修复和口腔面部修复装置。由于大多数基于稀土金属的磁铁，例如钐-钴基合金，具有很高的腐蚀倾向，因此它们首先被锡覆盖，然后被钛封装。然而，特别是牙齿装置上的高机械负荷可能导致钛胶囊破裂，合金可以直接接触生物流体。测试了钕-铁-硼和钐-钴（普通、锡和钛涂层）磁铁的细胞毒性。首先，将磁铁在培养介质中孵化多达7天，以准备用于细胞毒性测量的提取物。3T3小鼠成纤维细胞在提取物存在下培养，并通过中性红和代谢分析测量其活性。3T3成纤维细胞也直接与材料接触培养，并通过显微镜监测材料对细胞形态和生长的影响。研究发现，钐-钴磁铁具有很强的腐蚀倾向，并表现出相当大的细胞毒性。
IDENTIFICATION AND USE: Elemental samarium is a rhobohedral silver metal. It is used as a neutron absorber, dopant for laser crystals, metallurgical research, and in permanent magnets. HUMAN EXPOSURE AND TOXICITY: Samarium metal may be harmful if absorbed through the skin, swallowed or inhaled. It may cause skin, respiratory tract, and eye irritation. ANIMAL STUDIES: Technical magnetic materials are increasingly used for the development of magnetic retained dental prosthetic and orofacial epithetic devices. Since most of the magnets based on rare earth metals, such as samarium-cobalt based alloys, have a high tendency for corrosion, they were first coated by tin and then encapsulated by titanium. However, the high mechanical load particularly on dental devices may cause a rupture of the titanium capsule and the alloys can contact directly biological fluids. The cytotoxicity of neodymium-iron-boron and samarium-cobalt (plain, tin and titanium coated) magnets was tested. First, magnets were incubated up to 7 days in culture medium to prepare extracts for cytotoxicity measurements. 3T3 mouse fibroblasts were cultured in the presence of extracts and their viability measured by neutral red and metabolic assays. 3T3 fibroblasts were also cultured in direct contact with the materials and material induced effects on cell morphology and growth monitored by microscopy. It was found that samarium-cobalt magnets have a strong tendency for corrosion and exert a considerable cytotoxicity.
来源:Hazardous Substances Data Bank (HSDB)
