烯丙基巯基乙酸-(2-羟基乙基酰胺) | 78418-03-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 烯丙基巯基乙酸-(2-羟基乙基酰胺)
• 英文名称: 5-n-dodecanoylsalicylic acid
• 英文别名: 5-dodecanoyl-2-hydroxy-benzoic acid；5-Dodecanoyl-2-hydroxy-benzoesaeure；5-dodecanoyl salicylic acid；5-Dodecanoylsalicylic acid；5-dodecanoyl-2-hydroxybenzoic acid
• CAS: 78418-03-8
• 化学式: C₁₉H₂₈O₄
• 分子量: 320.429
• InChiKey: NCYSBHWOHLGEQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  5-十二烷基-2-羟基苯甲酸	5-dodecyl-2-hydroxy-benzoic acid	28488-52-0	C19H30O3	306.445
  ——	N-(3,4-Dichloro-benzyl)-5-dodecanoyl-2-hydroxy-benzamide	78417-93-3	C26H33Cl2NO3	478.459
  ——	N-(4-Bromo-phenyl)-5-dodecanoyl-2-hydroxy-benzamide	78417-73-9	C25H32BrNO3	474.438

反应信息

• 作为反应物：
  描述：

  烯丙基巯基乙酸-(2-羟基乙基酰胺) 在 盐酸 、 amalgamated zinc 作用下， 生成 5-十二烷基-2-羟基苯甲酸
  参考文献：
  名称：

  �ber einige neue Salicyls�urederivate

  摘要：

  DOI：

  10.1007/bf00906441
• 作为产物：
  描述：

  水杨酸甲酯 在 sodium hydroxide 、 三氯化铝 作用下， 以 二硫化碳 、 乙醇 为溶剂， 反应 18.0h， 生成 烯丙基巯基乙酸-(2-羟基乙基酰胺)
  参考文献：
  名称：

  Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus

  摘要：

  A series of 55 salicylamides, including 3,5-dibromo-, 5-n-alkyl-, and 5-n-acylsalicyloyl derivatives of various anilines, heterocyclic amines, benzylamines, and alkylamines, was synthesized and evaluated for in vitro antibacterial activity against Actinomyces viscosus, an adherent oral microorganism implicated in periodontal disease. The in vitro minimum inhibitory concentrations of 15 4'-bromosalicylanilides were found to correlate (r = 0.92) with estimated log D values. Several nonhalogenated salicylanilides, such as 5-n-hexyl- (40) and 5-n-decanoyl-4'-nitrosalicylanilide (47), were found to exhibit higher levels of in vitro antibacterial activity against a number of Actinomycetes than did tribromsalan (1) or fluorophene (2).

  DOI：

  10.1021/jm00142a023

文献信息

• Photostable cosmetic compositions comprising dibenzoylmethane/pyrrolidinone compounds
  申请人：RICHARD Herve

  公开号：US20090285868A1

  公开（公告）日：2009-11-19

  Photostable UV-photoprotecting cosmetic sunscreen compositions contain (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane compound sunscreen, (b) an effective radiation-photostablizing amount of at least one pyrrolidinone compound having the formula (I) below: and, advantageously, at least one liquid fatty phase and at least one lipophilic active sunscreen agent of low solubility, formulated into (c) a cosmetically acceptable support therefor.

  Photostable UV-防晒化妆品防晒组合物包含(a) 至少一种二苯甲酮类化合物防晒剂的有效UV-防晒量，(b) 至少一种具有以下公式(I)的吡咯烷酮化合物的有效辐射光稳定量：而且，有利的是，至少一种液态脂相和至少一种低溶解度的亲脂性活性防晒剂，配制成(c) 用于美容的可接受支持。
• Chemical enhancer and method
  申请人：L'OREAL S.A.

  公开号：US20040162272A1

  公开（公告）日：2004-08-19

  The present invention relates to compositions containing at least one salicylic acid derivative and at least one cosmetic, dermatologic, pharmaceutical, etc. active agent, where the salicylic acid derivative increases, enhances, etc., the efficacy of the active agent, as well as to methods of making and using such compositions. The invention further relates to a method for enhancing the efficacy of active agents with these salicylic acid derivatives.

  本发明涉及含有至少一种水杨酸衍生物和至少一种化妆品、皮肤科、药物等活性剂的组合物，其中水杨酸衍生物增强、增强等活性剂的功效，以及制备和使用这种组合物的方法。本发明还涉及一种利用这些水杨酸衍生物增强活性剂功效的方法。
• Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions
  申请人：Richard Hervé

  公开号：US20100143276A1

  公开（公告）日：2010-06-10

  Stable UV-screening cosmetic compositions contain at least one ester solvent derived from 4-carboxy-2-pyrrolidinone, of formula (I): in which: R 1 is a linear or branched C 1 -C 20 alkyl radical, and R 2 is a linear or branched C 1 -C 20 alkyl radical optionally containing a C 5 -C 6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical, and at least one liquid fatty phase and at least one lipophilic UV-screening active agent, the at least one ester derivative constituting a solvent for the at least one active agent in the at least one liquid fatty phase and/or constituting an agent for improving the solubility of the at least one active agent in the at least one fatty phase.

  稳定的紫外线防护化妆品组合物包含至少一种来自4-羧基-2-吡咯烷酮衍生的酯类溶剂，其化学式为（I）：其中：R1是线性或支链烷基，其碳数范围为C1-C20；R2是线性或支链烷基，可选含有C5-C6环成员、苯基、苄基或苯乙基，且其碳数范围为C1-C20；至少含有一种液态脂肪相和至少一种亲脂性紫外线防护活性剂，至少一种酯类衍生物在至少一种液态脂肪相中构成至少一种活性剂的溶剂和/或构成至少一种改善至少一种活性剂在至少一种脂肪相中溶解度的剂。
• Compositions for the treatment of acne containing a derivative of
  申请人：L'Oreal

  公开号：US05411742A1

  公开（公告）日：1995-05-02

  Composition for the treatment of acne containing a dispersion of vesicles of ionic or non-ionic amphiphilic lipids, the vesicles containing in the lipid phase at least one salicylic acid derivative of formula (I): ##STR1## in which R represents a linear or branched C.sub.11 -C.sub.17 alkyl radical; R'.sub.1, R'.sub.2, R'.sub.3, which are identical or different, represent a C.sub.1 -C.sub.18 alkyl or hydroxyalkyl radical, it being possible for one of the radicals R'.sub.1, R'.sub.2 or R'.sub.3 to be a benzyl radical. The derivative of formula (I) serves both as charged lipid and as anti-acne active ingredient. The derivatives of formula (I) in which, when R represents a C.sub.13 -C.sub.17 alkyl radical, R'.sub.1, R'.sub.2, R'.sub.3, when they are identical, do not represent a hydroxyethyl radical.

  含有离子或非离子两性脂质囊泡分散体的治疗痤疮组合物，该囊泡中的脂质相含有至少一种式(I)的水杨酸衍生物：##STR1## 其中R代表线性或支链C.sub.11-C.sub.17烷基基团；R'.sub.1，R'.sub.2，R'.sub.3相同或不同，代表C.sub.1-C.sub.18烷基或羟基烷基基团，其中可能有一个基团R'.sub.1，R'.sub.2或R'.sub.3是苄基基团。式(I)的衍生物既可作为带电的脂质，又可作为抗痤疮活性成分。当R代表C.sub.13-C.sub.17烷基基团时，当R'.sub.1，R'.sub.2，R'.sub.3相同时，它们不代表羟乙基基团的式(I)的衍生物。
• Polyamide particles as anti-irritant agents
  申请人：L'OREAL

  公开号：US20020176843A1

  公开（公告）日：2002-11-28

  The present invention relates to the use of polyamide particles as anti-irritant agents for reducing or eliminating the irritant effect of one or more compounds with an irritant effect, preferably in a cosmetic or dermatological composition.

  本发明涉及使用聚酰胺颗粒作为抗刺激剂，以减少或消除一个或多个具有刺激性的化合物的刺激作用，优选地在化妆品或皮肤科组合物中。