2-(羟基甲基)环戊醇 | 69618-32-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(羟基甲基)环戊醇
• 英文名称: 2-(hydroxymethyl)cyclopentanol
• 英文别名: 2-(hydroxymethyl)cyclopentan-1-ol
• CAS: 69618-32-2
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: UADBLZFWTJHOJC-UHFFFAOYSA-N

物化性质

• 沸点：
  252.7±8.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2906199090

反应信息

• 作为反应物：
  描述：

  2-(羟基甲基)环戊醇 在 Fe⁽²⁺⁾*C₁₂H₁₃N₃*2CF₃O₃S^(1-) 、 双氧水 作用下， 以 水 、 乙腈 为溶剂， 反应 0.25h， 以63%的产率得到2-(羟甲基)环戊酮
  参考文献：
  名称：

  Chemoselective, iron(ii)-catalyzed oxidation of a variety of secondary alcohols over primary alcohols utilizing H2O2 as the oxidant

  摘要：

  提出了一种温和的铁基催化体系，能够在室温下15分钟内利用H2O2作为氧化剂，在存在一级醇的情况下选择性地将二级醇氧化成相应的羟基酮。

  DOI：

  10.1039/c3cc41131a
• 作为产物：
  描述：

  2-甲氧羰基环戊酮 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以87%的产率得到2-(羟基甲基)环戊醇
  参考文献：
  名称：

  Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers

  摘要：

  Novel cyclopentane-based 3-phenyl-1-hydroxypropyl compounds were evaluated for inhibitory activity against the peripheral nerve sodium channel Na(v)1.7 and off-target activity against the cardiac potassium channel hERG. The stereochemistry of the hydroxyl group and substitution on the phenyl rings with either fluorinated O-alkyl or alkyl groups were found to be critical, for conferring potency against Na(v)1.7. A benchmark compound from this series displayed efficacy in rat models of inflammatory and neuropathic pain. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.051

文献信息

• Novel Thiazole Inhibitors of Fructose 1,6-Bishosphatase
  申请人：Dang Qun

  公开号：US20070225259A1

  公开（公告）日：2007-09-27

  Compounds of Formula I, their prodrugs and salts, their preparation and their uses are described.

  公式I的化合物，它们的前药和盐，它们的制备以及它们的用途被描述了。
• DDQ mediated regiospecific protection of primary alcohol and deprotection under neutral conditions: Application of new p -methoxy benzyl-pixyl ether as reagent of choice for nucleoside protection
  作者：Penjarla Srishylam、A. Raji Reddy、Shyamapada Banerjee、Santhosh Penta、Yogesh S. Sanghvi

  DOI：10.1016/j.tetlet.2017.05.066

  日期：2017.6

  A simple and efficient protocol is described for regiosepecific protection of primary hydroxyl group both in nucleosides and other molecules with p-methoxy-benzyl 2,7-dimethyl pixylether (MBDPE) in presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Furthermore, swift deprotection of 2, 7-dimethylpixyl (DMPx) is accomplished with DDQ in MeOH. Both procedures are successfully implemented on

  一个简单的，高效的协议被用于在两个核苷和其它分子与伯羟基的保护regiosepecific描述p -米乙氧基b enzyl 2,7- d imethyl p ixyl ë疗法（MBDPE）中的存在2,3-二氯5,6-二氰基-1,4-苯醌（DDQ）。此外，用DDQ在MeOH中快速脱保护2，7-二甲基pixyl（DMPx）。两种方法均在革兰氏级合成修饰核苷上成功实现。该方案为DMPx基团的选择性保护和脱保护提供了温和和中性的条件，同时可与其他常规保护基团（例如苯甲酰基，苄基，THP，TBDPS和丙酮化物）相容。
• Copper(II)nitrate catalyzed regioselective protection of primary alcohols with 4,4′-dimethoxytrityl and 2,7-dimethyl-9-phenyl xanthen-9-yl groups in nucleosides and carbohydrates
  作者：Srishylam Penjarla、S. Rajendra Prasad、Dhande Sudhakar Reddy、Shyamapada Banerjee、Santhosh Penta、Yogesh S. Sanghvi

  DOI：10.1080/15257770.2018.1460480

  日期：2018.4.3

  ABSTRACT Regioselective protection of primary hydroxyl group in nucleoside and carbohydrate analogs was accomplished using dimethoxytrityl alcohol (DMTr-OH) or dimethylpixyl alcohol (DMPx-OH) in presence of copper(II)nitrate as a Lewis acid catalyst. Excellent selectivity was observed for the protection of primary hydroxyl group over secondary while glycosidic bond remain unaffected. Utility of this

  摘要 在作为路易斯酸催化剂的硝酸铜 (II) 存在下，使用二甲氧基三苯甲醇 (DMTr-OH) 或二甲基苯甲醇 (DMPx-OH) 实现了核苷和碳水化合物类似物中伯羟基的区域选择性保护。观察到优异的选择性保护伯羟基而不是仲羟基，而糖苷键不受影响。通过脂肪族无环和环状二醇的 DMTr 和 DMPx 保护进一步举例说明了该方法的实用性。
• Novel Phosphinic Acid-Containing Thyromimetics
  申请人：Erion Mark D.

  公开号：US20090028925A1

  公开（公告）日：2009-01-29

  The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

  本发明涉及含有磷酸基T3拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟拟
• Acid amplifiers
  申请人：Brainard Robert L.

  公开号：US08501382B1

  公开（公告）日：2013-08-06

  There are disclosed sulfonic acid precursor compositions, as are methods of using these compositions in, for example, photolithography. Other embodiments are also disclosed.

  已披露磺酸前体组合物，以及在例如光刻中使用这些组合物的方法。还披露了其他实施方式。