A palladium‐catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2‐position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl benzoates afforded 2,4‐diaryloxazoles as products, while 2‐benzoyl‐substituted cyanomethyl benzoates delivered 3‐benzoyl‐4‐aryl‐isocoumarins selectively
Synthesis of 2,4,5-trisubstituted oxazoles from 1,2-diketones and amines by using an electrochemical method
作者:Liangxiao Wei、Gaoqing Yuan
DOI:10.1016/j.tet.2023.133246
日期:2023.2
An efficient electrochemical synthesis of trisubstituted oxazoles from readily available 1,2-diketones and amines is described. With KI as the electrocatalyst, t-BuOK as the base and MeOH as the electrolytic solvent, the electrochemical synthesis could be smoothly performed in an undivided cell to afford 2,4,5-trisubstituted oxazoles in good yields at room temperature.
描述了从容易获得的 1,2-二酮和胺中高效电化学合成三取代恶唑。以 KI 为电催化剂,t -BuOK 为碱,MeOH 为电解溶剂,电化学合成可以在未分隔的电池中顺利进行,在室温下以良好的产率得到 2,4,5-三取代恶唑。
Method for treating atherosclerosis employing an aP2 inhibitor and combination
申请人:——
公开号:US20020035064A1
公开(公告)日:2002-03-21
A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.