3-ethyl-4-methyl-oxetan-2-one | 114592-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-ethyl-4-methyl-oxetan-2-one
• 英文别名: 3-Aethyl-4-methyl-oxetan-2-on；3-Ethyl-4-methyloxetan-2-one
• CAS: 114592-79-9
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: PAIRTJOPUAQMRQ-UHFFFAOYSA-N

物化性质

• 沸点：
  62-65 °C(Press: 12 Torr)
• 密度：
  0.983±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-ethyl-4-methyl-oxetan-2-one 生成 methylammonium carbonate 、 2-戊烯
  参考文献：
  名称：

  Salkowski, Journal fur praktische Chemie (Leipzig 1954), 1923, vol. <2>106, p. 258,263

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 、 sodium carbonate 作用下， 生成 3-ethyl-4-methyl-oxetan-2-one 、 2-戊烯
  参考文献：
  名称：

  Johansson; Hagmann, Chemische Berichte, 1922, vol. 55, p. 658

  摘要：

  DOI：

文献信息

• Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
  申请人：The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone

  公开号：US11376242B2

  公开（公告）日：2022-07-05

  Provided are methods and compositions for identifying candidate agents for treatment of obesity, liver disease, and/or diabetes. Such methods include, e.g., contacting a mammalian cell or cell population with a test agent, and measuring an expression level and/or activity level of ClpP in the mammalian cell or in cells of the cell population. Also provided are methods and compositions for treating an individual (e.g., one who is obese and/or has diabetes). Treatment methods include administering an inhibitor of ClpP to the individual (e.g., to prevent or reduce weight gain, to increase insulin sensitivity, and/or to increase glucose tolerance).

  本文提供了用于鉴定治疗肥胖症、肝病和/或糖尿病的候选药物的方法和组合物。这些方法包括，例如，用测试剂接触哺乳动物细胞或细胞群，并测量哺乳动物细胞或细胞群中 ClpP 的表达水平和/或活性水平。还提供了治疗个体（如肥胖和/或糖尿病患者）的方法和组合物。治疗方法包括给个体施用ClpP抑制剂（例如，防止或减少体重增加、增加胰岛素敏感性和/或增加葡萄糖耐量）。
• Johansson; Hagmann, Chemische Berichte, 1922, vol. 55, p. 658
  作者：Johansson、Hagmann

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR TREATING OBESITY AND/OR DIABETES AND FOR IDENTIFYING CANDIDATE TREATMENT AGENTS
  申请人：The J. David Gladstone Institutes

  公开号：EP3429567A1

  公开（公告）日：2019-01-23
• TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20140243255A1

  公开（公告）日：2014-08-28

  The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1.
• LACTONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US20170313669A1

  公开（公告）日：2017-11-02

  Provided herein are lactone compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as inhibitors of serine hydrolases, such as ABHD16A. Furthermore, the subject compounds and compositions may be useful for the treatment of, for example, PHARC and other neuroinflammatory diseases.