3-(1H-indol-2-yl)quinoline | 99285-62-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(1H-indol-2-yl)quinoline
• 英文别名: 3-indol-2-ylquinoline；2-(3-quinolyl)indole；3-(indol-2-yl)-quinoline
• CAS: 99285-62-8
• 化学式: C₁₇H₁₂N₂
• 分子量: 244.296
• InChiKey: GNZDZFSSIXGWIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 3-(1H-indol-2-yl)quinoline 在 sodium acetate 作用下， 反应 20.0h， 以34 mg的产率得到5-acetyl-5a,6-dihydroindolo<2,1-f>benzo<1,6>naphthyridin-7(6H)-one
  参考文献：
  名称：

  Baradarani, M. Mehdi; Dalton, Lesley; Heatley, Frank, Journal of the Chemical Society. Perkin transactions I, 1985, p. 1503 - 1508

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙酰基喹啉 在 PPA 作用下， 以 甲苯 为溶剂， 反应 36.25h， 生成 3-(1H-indol-2-yl)quinoline
  参考文献：
  名称：

  Baradarani, M. Mehdi; Dalton, Lesley; Heatley, Frank, Journal of the Chemical Society. Perkin transactions I, 1985, p. 1503 - 1508

  摘要：

  DOI：

文献信息

• Gold(<scp>i</scp>)-catalyzed synthesis of 2-substituted indoles from 2-alkynylnitroarenes with diboron as reductant
  作者：Wenqiang Fu、Kai Yang、Jinglong Chen、Qiuling Song

  DOI：10.1039/c7ob01918a

  日期：——

  An efficient method for the synthesis of 2-substituted indoles via a diboron/base promoted tandem reductive cyclization of o-alkynylnitroarene under Au catalysis conditions has been disclosed. This reaction is efficient and convenient, affording 2-substituted indoles with broad functional groups tolerance and excellent yields.

  公开了一种在Au催化条件下通过二硼/碱促进的邻炔基硝基芳烃的串联还原还原环化反应合成2-取代的吲哚的有效方法。该反应是有效且方便的，提供具有宽泛的官能团耐受性和优异的产率的2-取代的吲哚。
• Synthesis of 2-substituted indoles by palladium-catalyzed heteroannulation with Pd–NaY zeolite catalysts
  作者：Ki Bum Hong、Chul Wee Lee、Eul Kgun Yum

  DOI：10.1016/j.tetlet.2003.11.075

  日期：2004.1

  Various 2-substituted indoles were prepared by heteroannulation of o-iodoanilines and terminal alkynes in a one-pot reaction with a Pd(II)–NaY zeolite catalyst. The product formation largely depended on the solvent, base, and reaction temperature. The recycled catalyst showed good reusability in the heteroannulation reaction.

  通过邻位碘苯胺和末端炔烃与Pd（II）-NaY沸石催化剂的一锅法反应，制得各种2-取代的吲哚。产物的形成很大程度上取决于溶剂，碱和反应温度。再循环的催化剂在杂环化反应中显示出良好的可重复使用性。
• Treatment of protein folding disorders
  申请人：Carter D. Michael

  公开号：US20070015813A1

  公开（公告）日：2007-01-18

  In certain embodiments, the invention is directed to a method for treating a protein folding disorder comprising administering to a subject a compound of the formulas disclosed. In preferred embodiments, the compounds are bis-indole compounds.

  在某些实施例中，本发明涉及一种治疗蛋白质折叠紊乱的方法，包括向受试者给予公开的配方的化合物。在优选实施例中，这些化合物是双吲哚化合物。
• [EN] QUINOLINE-INDOLE ANTIMICROBIAL AGENTS, USES AND COMPOSITIONS RELATED THERETO<br/>[FR] AGENTS ANTIMICROBIENS QUINOLEINE-INDOLE, ET UTILISATIONS ET COMPOSITIONS ASSOCIEES
  申请人：SEPRACOR INC

  公开号：WO2000034265A2

  公开（公告）日：2000-06-15

  Compounds presented by the following general structure: inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.

  具备以下一般结构的化合物：抑制细菌微生物的生长。此外，本发明还提供了一种能够杀灭细菌微生物的方法及药物制剂。
• 2-Aryl and 2-Heteroaryl Indoles from 1-Alkynes and <i>o</i>-Iodotrifluoroacetanilide through a Domino Copper-Catalyzed Coupling−Cyclization Process
  作者：Sandro Cacchi、Giancarlo Fabrizi、Luca M. Parisi

  DOI：10.1021/ol035378r

  日期：2003.10.1

  [GRAPHICS]A general method for the synthesis of 2-aryl and 2-heteroaryl indoles from aryl iodides and 1-alkynes through a domino copper-catalyzed process is reported. The best results have been obtained with [Cu(phen)(PPh3)(2)]NO3 in the presence of K3PO4 in toluene or dioxane at 110 degreesC. 2-Aryl and 2-heteroaryl indoles can also be isolated in good yields by using catalysts derived from CuI and PPh3 in dioxane at 110 degreesC.