S-1-propyl-S'-(α,α'-dimethyl-α''-acetic acid)trithiocarbonate | 1254954-46-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-1-propyl-S'-(α,α'-dimethyl-α''-acetic acid)trithiocarbonate
• 英文别名: 2-(propylthiocarbonothioylthio)-2-methylpropionoic acid；2-[[(propylsulfanyl)carbonothioyl]sulfanyl]-2-methylpropionic acid；PDMAT；2-propylsulfanylthiocarbonylsulfanyl-2-methyl propionic acid；2-Methyl-2-(((propylthio)carbonothioyl)thio)propanoic acid；2-methyl-2-propylsulfanylcarbothioylsulfanylpropanoic acid
• CAS: 1254954-46-5
• 化学式: C₈H₁₄O₂S₃
• 分子量: 238.396
• InChiKey: QGLIGUHRECWBED-UHFFFAOYSA-N

物化性质

• 沸点：
  405.4±24.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  S-1-propyl-S'-(α,α'-dimethyl-α''-acetic acid)trithiocarbonate 、 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  用于高效触发释放和程序化酶促反应的自毁聚合物体

  摘要：

  刺激触发的嵌段共聚物囊泡或聚合物囊泡的分解通常是通过双层形成嵌段的溶解度转换来实现的，这需要大多数重复单元的协同变化。在这里，我们报告了一种替代方法，通过结合疏水块表现出刺激触发的头对尾级联解聚特征。带有该基序的两亲性嵌段共聚物自组装成自毁性聚合物囊泡（SIPsomes）。通过封端部分的模块化设计，可见光、紫外线和还原环境可用于驱动 SIPsomes 分解为水溶性小分子和亲水性嵌段。SIPsomes 的设计允许触发药物共同释放和可控地访问质子、氧气和酶底物。我们还演示了编程（OR-，

  DOI：

  10.1021/ja5030832
• 作为产物：
  描述：

  二硫化碳 、 丙烷-1-硫醇 、 2-溴-2-甲基丙酸 在 potassium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 反应 3.0h， 以30%的产率得到S-1-propyl-S'-(α,α'-dimethyl-α''-acetic acid)trithiocarbonate
  参考文献：
  名称：

  在环境条件下氧气引发和调节的受控自由基聚合

  摘要：

  在环境温度和大气条件下进行了快速的氧引发和调节的受控自由基聚合。三乙基硼烷与氧气之间的反应提供了乙基，该乙基引发和介导自由基聚合。使用RAFT链转移剂（CTA）可实现受控的自由基聚合，而无需任何除氧过程，可在短时间内（15分钟）提供定义明确的聚合物，其几乎完全转化（> 95％）。高通量筛选用于发现各种CTA和单体的合适条件。为了显示该方法的多功能性，通过高通量合成技术，在1小时内合成了一个包含25种定义明确的，具有不同组成（嵌段共聚物和统计共聚物）和分子量的聚合物的聚合物库。

  DOI：

  10.1002/anie.201805212

文献信息

• Heterofunctional polymers and core–shell nanoparticles via cascade aminolysis/Michael addition and alkyne–azide click reaction of RAFT polymers
  作者：Zesheng An、Wei Tang、Minghong Wu、Zheng Jiao、Galen D. Stucky

  DOI：10.1039/b816578e

  日期：——

  A convenient methodology involving cascade aminolysis/Michael addition and alkyne–azide click reaction was developed for polymers and polymeric core–shell nanoparticles, synthesized via RAFT-mediated homogeneous and heterogeneous polymerisation processes, respectively, to provide well-defined heterofunctional polymeric materials.

  开发了一种便捷的方法学，通过级联氨基解/迈克尔加成反应和炔烃-叠氮点击反应，用于分别由RAFT介导的均相和非均相聚合过程合成的聚合物及聚合物核-壳纳米粒子，以提供定义良好的异功能化聚合物材料。
• Metallo-Supramolecular Cyclic Polymers
  作者：Ke Zhang、Yongping Zha、Bo Peng、Yongming Chen、Gregory N. Tew

  DOI：10.1021/ja407381f

  日期：2013.10.30

  Cyclic brush polymers represent an exciting new macromolecular topology. For the first time, this new topology has been combined with metallo-supramolecular interactions to construct novel cyclic brush polymers. Here, ring-expansion metathesis polymerization was used to synthesize a universal cyclic template with a polynorbornene backbone, which was further modified with the metal-chelating synthon terpyridine. The terpyridine side chains served as the key supramolecular unit for the creation of cyclic polymer brushes and gels. This metallo-supramolecular functionality allowed direct visualization of the cyclic brush polymers by transmission electron microscopy for the first time. This demonstration should open a new area in which supramolecular interactions are used to build an array of novel cyclic brush copolymers as well as other cyclic-polymer-based architectures generating new materials.
• Highly Controlled Open Vessel RAFT Polymerizations by Enzyme Degassing
  作者：Robert Chapman、Adam J. Gormley、Karla-Luise Herpoldt、Molly M. Stevens

  DOI：10.1021/ma5021209

  日期：2014.12.23

  Intolerance to oxygen is a key limitation in many reactions and particularly in controlled radical polymerizations. Here we introduce the use of enzymes such as glucose oxidase (GOx) to deoxygenate reversible additionfragmentation chain transfer polymerizations (Enz-RAFT), facilitating the preparation of highly controlled polymers in vessels open to ambient oxygen. Because the removal of oxygen is so efficient, very low concentrations of GOx and initiator can be used, enabling excellent control which is demonstrated by pseudoliving polymerization kinetics and the preparation of multiblock copolymers with narrow molecular weight distributions (M-w/M-n < 1.15). GOx retains sufficient activity to facilitate polymerization not only in aqueous solutions but also in a range of water/organic solvent mixtures, and we demonstrate the use of this technique to perform open vessel Enz-RAFT polymerizations in various methanol and dioxane/water mixtures.
• Gold Nanoparticle Conjugates and Uses Thereof
  申请人：Boyes Stephen G.

  公开号：US20090060839A1

  公开（公告）日：2009-03-05

  The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient.
• Biomedical devices
  申请人：Linhardt Jeffrey G.

  公开号：US20100317809A1

  公开（公告）日：2010-12-16

  Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer comprising one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming monomers are disclosed.