2-iodo-decan-1-ol | 127201-29-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 2-iodo-decan-1-ol
• 英文别名: 2-iodo-1-decanol；2-Iododecan-1-ol
• CAS: 127201-29-0
• 化学式: C₁₀H₂₁IO
• 分子量: 284.181
• InChiKey: DODBHWJCNQEXFB-UHFFFAOYSA-N

物化性质

• 沸点：
  291.2±23.0 °C(Predicted)
• 密度：
  1.351±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正癸烯 在 potassium iodate 、 硫酸 、 水 、 potassium iodide 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 生成 1-iodo-decan-2-ol 、 2-iodo-decan-1-ol
  参考文献：
  名称：

  用2：1溴化物/溴酸盐和碘化物/碘酸盐试剂对烯烃进行邻位官能化的比较研究

  摘要：

  比较评价在邻位卤代醇，卤代甲基醚和卤代乙酸盐的合成由从使用2-烯烃：1溴- /的BrO 3 -和我- / IO 3 -试剂。在许多情况下，两种试剂都以高收率选择性地提供产物。得到最高卤素原子效率为97％和溴93％- /的BrO 3 -和我- / IO 3 - ，分别。这两个试剂，我- / IO 3 -已确定“丙烯酰胺”是用于直链烯烃的邻位官能化以及用于制备卤代乙酸酯的优选试剂。然而，只有溴- /的BrO 3 -是有效的邻位官能反式-二苯乙烯和查耳酮。

  DOI：

  10.1016/j.tet.2009.01.095

文献信息

• Regio- and Stereoselective Synthesis of β-Halohydrins from 1,2-Epoxides with Ammonium Halides in the Presence of Metal Salts
  作者：Marco Chini、Paolo Crotti、Cristina Gardelli、Franco Macchia

  DOI：10.1016/s0040-4020(01)92271-9

  日期：1992.1

  A simple efficient, stereoselective, and regioselective method for the synthesis of beta-chlorohydrins, beta-bromohydrins, and beta-iodohydrins by the direct opening of 1,2-epoxides with the corresponding ammonium halide in acetonitrile, in the presence of metal salts. is described. This new method appears to be of general use and competitive with the other methods previously reported.
• Green approach for the conversion of olefins into vic-halohydrins using N-halosuccinimides in ionic liquids
  作者：J.S. Yadav、B.V.S. Reddy、Gakul Baishya、S.J. Harshavardhan、Ch. Janardhana Chary、Manoj Kumar Gupta

  DOI：10.1016/j.tetlet.2005.03.108

  日期：2005.5

  Alkenes undergo smooth bromo- and iodohydroxylation with N-bromo- and N-iodosuccinimides/water, respectively, using the air and moisture stable ionic liquid [bmim]BF4 as a novel recyclable reaction medium in high to quantitative yields. N-Halosuccinimides show enhanced reactivity in ionic liquids thereby reducing the reaction times and improving the yields considerably. (c) 2005 Published by Elsevier Ltd.
• [EN] 3-SUBSTITUTED CLAVAMS FOR CALPAIN INHIBITION<br/>[FR] CLAVAMS 3-SUBSTITUES SERVANT A L'INHIBITION DE LA CALPAINE
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：WO1998037084A1

  公开（公告）日：1998-08-27

  (EN) Pharmaceutical compositions and methods of inhibiting calpain using novel 3-substituted clavams of formula (I) in which: R is -CO-X-(CH2)nY, -CH2OCO-(CH2)n-A or -(CH2)n-B; X is O, NH or NH-C6H4-; Y is CH3, -PhZ, NH-D or, when n is 0 and X is NH, -CH(PhZ)2; n is 0-20 or 4-20 when X is O; D is hydrogen or an amino protecting group; A is COOH, COOalkyl, NH(CH2)nPh or NH-D; Z is one or two groups substituted on the phenyl ring independently selected from halogen, amino, hydroxy, alkoxy, alkyl, arylalkyl and B is CH3 or -(PhZ).(FR) L'invention concerne des compositions pharmaceutiques et des procédés destinés à inhiber la calpaïne, utilisant de nouveaux clavams 3-substitués représentés par la formule (I), dans laquelle R est -CO-X-(CH2)nY, -CH2OCO-(CH2)n-A ou -(CH2)n-B; X est O, NH ou NH-C6H4-; Y est CH3, -PhZ, NH-D ou, lorsque n est égal à 0 et X est NH, -CH(PhZ)2; n est une valeur comprise entre 0 et 20, ou entre 4 et 20 lorsque X est O; D est H ou un groupe amino de protection; A est COOH, COOalkyle, NH(CH2)nPh ou NH-D; Z est un ou deux groupes substitués sur le noyau phényle sélectionné(s) indépendamment dans le groupe constitué par un halogène, amino, hydroxy, alkoxy, alkyle, et arylalkyle; et B est CH3 ou -(PhZ).
• [EN] LOW TRANSITION TEMPERATURE MIXTURES OR DEEP EUTECTIC SOLVENTS AND PROCESSES FOR PREPARATION THEREOF<br/>[FR] MÉLANGES À FAIBLE TEMPÉRATURE DE TRANSITION OU SOLVANTS EUTECTIQUES PROFONDS ET PROCÉDÉS POUR LEUR PRÉPARATION
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2016073149A1

  公开（公告）日：2016-05-12

  A low transition temperature mixture (LTTM) or deep eutectic solvent (DES) useful as a lubricating oil base stock and lubricating oil including a eutectic mixture of at least a first component and at least a second component. The at least first component comprises a hydrogen bond acceptor and the at least second component comprises a hydrogen bond donor. The eutectic mixture includes an equilibrium phase between the at least first component and the at least second component. The equilibrium phase does not exhibit physical characteristics of the at least first component in an unmixed state and the at least second component in an unmixed state. The at least first component and the at least second component form an intermolecular interaction between each other sufficient to prevent crystallization of the at least first component and the at least second component in the eutectic mixture. The eutectic mixture is a liquid at 20°C.
• Comparative study of the vicinal functionalization of olefins with 2:1 bromide/bromate and iodide/iodate reagents
  作者：Manoj K. Agrawal、Subbarayappa Adimurthy、Bishwajit Ganguly、Pushpito K. Ghosh

  DOI：10.1016/j.tet.2009.01.095

  日期：2009.4

  halohydrins, halo methyl ethers, and halo acetates from olefins using 2:1 Br−/BrO3− and I−/IO3− reagents. In many cases both reagents afforded products selectively in high yields. The highest halogen atom efficiencies attained were 97% and 93% for Br−/BrO3− and I−/IO3−, respectively. Of the two reagents, I−/IO3− was established to be the preferred reagent for vicinal functionalization of linear alkenes and

  比较评价在邻位卤代醇，卤代甲基醚和卤代乙酸盐的合成由从使用2-烯烃：1溴- /的BrO 3 -和我- / IO 3 -试剂。在许多情况下，两种试剂都以高收率选择性地提供产物。得到最高卤素原子效率为97％和溴93％- /的BrO 3 -和我- / IO 3 - ，分别。这两个试剂，我- / IO 3 -已确定“丙烯酰胺”是用于直链烯烃的邻位官能化以及用于制备卤代乙酸酯的优选试剂。然而，只有溴- /的BrO 3 -是有效的邻位官能反式-二苯乙烯和查耳酮。