1-(4-nitrophenyl)-2-((4-nitrophenyl)sulfonyl)ethanone | 86516-57-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-nitrophenyl)-2-((4-nitrophenyl)sulfonyl)ethanone
• 英文别名: 2-(4-nitro-benzenesulfonyl)-1-(4-nitro-phenyl)-ethanone；2-(4-Nitro-benzolsulfonyl)-1-(4-nitro-phenyl)-aethanon；1-(4-Nitrophenyl)-2-(4-nitrophenyl)sulfonylethanone
• CAS: 86516-57-6
• 化学式: C₁₄H₁₀N₂O₇S
• 分子量: 350.309
• InChiKey: JSRIWMXCYNLWJI-UHFFFAOYSA-N

物化性质

• 熔点：
  257 °C(Solv: ethanol (64-17-5))
• 沸点：
  617.9±55.0 °C(Predicted)
• 密度：
  1.517±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  151
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 双氧水 、 乙酸酐 、 溶剂黄146 作用下， 生成 1-(4-nitrophenyl)-2-((4-nitrophenyl)sulfonyl)ethanone
  参考文献：
  名称：

  α-(4-Aminophenylsulfonyl)-acetophenone Derivatives

  摘要：

  DOI：

  10.1021/ja01178a074

文献信息

• Visible-light-promoted oxidative difunctionalization of alkenes with sulfonyl chlorides to access β-keto sulfones under aerobic conditions
  作者：Teng-fei Niu、Jing Cheng、Chang-li Zhuo、Ding-yun Jiang、Xing-ge Shu、Bang-qing Ni

  DOI：10.1016/j.tetlet.2017.08.013

  日期：2017.9

  A mild, practical and efficient strategy to prepare β-keto sulfones has been developed by visible light promoted reactions. This reaction involves Ir(ppy)2(dtbbpy)PF6 catalyzed direct funcationalization of alkenes with sulfonyl chlorides under mild conditions. Air was used as oxidant without any additives. The transformation affords the corresponding products in moderate to high yields.

  通过可见光促进的反应，已经开发出一种温和，实用和有效的制备β-酮砜的策略。该反应涉及在温和的条件下，Ir（ppy）2（dtbbpy）PF 6催化的烯烃与磺酰氯的直接官能化反应。空气被用作氧化剂，没有任何添加剂。该转化以中等至高产率提供了相应的产物。
• Rapid synthesis of sulfone derivatives as potential anti-infectious agents
  作者：C. Curti、M. Laget、A. Ortiz Carle、A. Gellis、P. Vanelle

  DOI：10.1016/j.ejmech.2006.12.015

  日期：2007.6

  An original one-pot microwave reaction was developed for the synthesis of sulfone derivatives as new potent antimicrobial agents. This ecofriendly methodology conducted in 30 min led to desired products with good yields. The sulfones (4a and 4b) were obtained via the reaction of 3a with the corresponding halo-derivatives in the presence of sodium hydride.All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two gram positive, and two gram negative ones) and two yeasts. The disk diffusion method has shown an interesting antibacterial activity for seven compounds (3b-g and 4b) against Staphylococcus attreus. Among these seven compounds, five derivatives (3b-e and 3g) showed activity against Candida tropicalis. (c) 2007 Elsevier Masson SAS. All rights reserved.
• α-(4-Aminophenylsulfonyl)-acetophenone Derivatives
  作者：Price. Truitt、Richard. Stead、Loren M. Long、William J. Middleton

  DOI：10.1021/ja01178a074

  日期：1949.10