(2-methylcyclohex-2-enyl)methanol | 78426-31-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-methylcyclohex-2-enyl)methanol
• 英文别名: (2-Methylcyclohex-2-en-1-yl)methanol
• CAS: 78426-31-0
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: WMPNCBLXIFPBPW-UHFFFAOYSA-N

物化性质

• 沸点：
  196.4±9.0 °C(Predicted)
• 密度：
  0.925±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (2-Methylcyclohex-2-en-1-yl)methyl 4-methylbenzenesulfonate 在 sodium hydroxide 、 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以30%的产率得到(2-methylcyclohex-2-enyl)methanol
  参考文献：
  名称：

  均烯丙基甲苯磺酸盐的亲核取代：位阻和构象刚度的影响

  摘要：

  报道了具有不同程度的阻碍和刚性的均烯丙基甲苯磺酸盐的亲核取代作用的比较研究。π键的参与受阻和刚性以及弱亲核试剂（例如水或二甲基甲酰胺）的帮助。

  DOI：

  10.1016/s0040-4020(01)00415-x

文献信息

• (2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors
  申请人：ALLERGAN SALES, INC.

  公开号：US20020161051A1

  公开（公告）日：2002-10-31

  Compounds of formula (i) and of formula (ii) 1 wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate &agr; 2B and/or &agr; 2C adrenergic receptors in preference over &agr; 2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.

  式（i）和式（ii）的化合物 其中符号的含义在说明书中披露，特别或选择性地调节&agr; 2B 和/或&agr; 2C 肾上腺素受体，优先于&agr; 2A 肾上腺素受体，因此对缓解慢性疼痛和触痛有用，并且几乎没有或只有极小的心血管和/或镇静活性。
• Dimethylaluminum chloride catalyzed ene reactions of aldehydes
  作者：Barry B. Snider、David J. Rodini、Thomas C. Kirk、Robert Cordova

  DOI：10.1021/ja00366a031

  日期：1982.1
• Formaldehyde Encapsulated in Zeolite:  A Long-Lived, Highly Activated One-Carbon Electrophile to Carbonyl-Ene Reactions
  作者：Takahiro Okachi、Makoto Onaka

  DOI：10.1021/ja039737p

  日期：2004.3.3

  Gaseous formaldehyde is extremely unstable and readily undergoes self-polymerization to a solid paraformaldehyde or disproportionation to methanol and formic acid in the presence of moisture. We disclose a simple method to stably store such a labile formaldehyde as a monomer in a nanoporous faujasite zeolite at 5 degrees C for at least 50 days without self-polymerization or disproportionation. The greater stability of formaldehyde encapsulated in zeolite was confirmed by 13C MAS NMR spectroscopy. Formaldehyde was not only stabilized within the zeolite cages but functioned as a powerful electrophile toward various olefins. Zeolite-encapsulated formaldehyde was proved to be a stable but highly reactive C1 reagent.
• Scandium(III) triflate catalyzed synthesis of primary homoallylic alcohols via carbonyl-ene reaction
  作者：Sabera Sultana、Somasekhar Bondalapati、Kiran Indukuri、Paramartha Gogoi、Pipas Saha、Anil K. Saikia

  DOI：10.1016/j.tetlet.2013.01.046

  日期：2013.3

  Scandium trifluoromethanesulfonate can efficiently catalyze the formation of homoallylic alcohols from olefins and paraformaldehyde in good yields. (c) 2013 Elsevier Ltd. All rights reserved.
• Reactions of the formaldehyde-trimethylaluminum complex with alkenes
  作者：Barry B. Snider、Robert Cordova、Robert T. Price

  DOI：10.1021/jo00140a009

  日期：1982.9