4-methyldec-1-yn-4-ol | 74120-68-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyldec-1-yn-4-ol
• 英文别名: 4-Methyl-dec-1-in-4-ol
• CAS: 74120-68-6
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: OCPUNOYFRXNPCT-UHFFFAOYSA-N

物化性质

• 沸点：
  105 °C(Press: 15 Torr)
• 密度：
  0.879±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methyldec-1-yn-4-ol 、 异氰酸甲酯 在 三乙胺 作用下， 生成 methyl-carbamic acid-(1-hexyl-1-methyl-but-3-ynyl ester)
  参考文献：
  名称：

  The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep

  摘要：

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.

  DOI：

  10.1080/08964280109595773
• 作为产物：
  描述：

  3-溴丙炔 、 仲辛酮 在 氢化铝 、 lead(II) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以95%的产率得到4-methyldec-1-yn-4-ol
  参考文献：
  名称：

  由PbCl2活化的炔丙基溴和铝制备有机铝试剂及其在羰基衍生物上的区域和非对映选择性加成

  摘要：

  通过在PbCl 2（1 mol％）存在下将铝直接插入到炔丙基溴中，可以很容易地制备出各种炔丙基和烯丙基铝试剂。这些有机铝试剂可与羰基化合物反应，以高至极高的选择性和高非对映选择性提供相应的烯丙醇或均丙炔醇。

  DOI：

  10.1002/chem.201000523

文献信息

• REACTION OF PROPARGYL BROMIDE AND TRIMETHYLSILYLPROPARGYL IODIDE WITH METALLIC TIN, ALUMINUM, AND ALDEHYDES OR KETONES. SELECTIVE SYNTHESIS OF β-ACETYLENE, β-TRIMETHYLSILYLACETYLENE, AND α-TRIMETHYLSILYLALLENE ALCOHOLS
  作者：Junzo Nokami、Takashi Tamaoka、Tadao Koguchi、Rokuro Okawara

  DOI：10.1246/cl.1984.1939

  日期：1984.11.5

  β-Acetylenic and α-allenic alcohols were synthesized selectively by the reaction of aldehydes and ketones with organotin compounds prepared by treatment of propargyl bromide or trimethylsilylpropargyl iodide with metallic tin and aluminum in a suitable solvent.

  通过醛和酮与有机锡化合物反应选择性地合成β-乙炔和α-丙二烯醇，该有机锡化合物是通过在合适的溶剂中用金属锡和铝处理炔丙基溴或三甲基甲硅烷基炔丙基碘而制备的。
• Preparation and reactions of samarium diiodide in nitriles
  作者：Béatrice Hamann、Jean-Louis Namy、Henri B. Kagan

  DOI：10.1016/0040-4020(96)00861-7

  日期：1996.11

  Samarium diiodide can be prepared from samarium metal in various nitriles. Because of its chemical inertness pivalonitrile is the most suitable solvent. Organic reactions mediated by SmI2 are slower than in THF, but selectivities are often improved. Reactions are greatly accelerated by addition of catalytic amounts of some transition metal salts.

  可以从各种腈中的金属metal制备二碘化prepared。由于其化学惰性，新戊腈是最合适的溶剂。由SmI 2介导的有机反应比在THF中慢，但选择性通常得到改善。通过加入催化量的某些过渡金属盐，可大大加快反应速度。
• Divalent lanthanide derivatives in organic synthesis. 1. Mild preparation of samarium iodide and ytterbium iodide and their use as reducing or coupling agents
  作者：P. Girard、J. L. Namy、H. B. Kagan

  DOI：10.1021/ja00528a029

  日期：1980.4
• Organosamariums: preparation using diiodosamarium and reactivity in tetrahydropyran
  作者：Béatrice Hamann-Gaudinet、Jean-Louis Namy、Henri B. Kagan

  DOI：10.1016/s0022-328x(98)00666-4

  日期：1998.9

  Diiodosamarium prepared in tetrahydropyran reduces allylic, benzylic and alkyl halides at 0 or -15 degrees C to give organosamariums which are stable under these conditions. The reactivity of these organometallics has been explored, showing that they are very selective reagents. (C) 1998 Elsevier Science S.A. All rights reserved.
• GIRARD P.; NAMY J. I.; KAGAN H. B., J. AMER. CHEM. SOC., 1980, 102, NO 8, 2693-2698
  作者：GIRARD P.、 NAMY J. I.、 KAGAN H. B.

  DOI：——

  日期：——