2-[2-[2-(4-氨基苯氧基)乙氧基]乙氧基]乙醇 | 18790-97-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-[2-[2-(4-氨基苯氧基)乙氧基]乙氧基]乙醇
• 英文名称: 2-(2-(2-(4-amino-phenoxy)-ethoxy) -ethoxy)-ethanol
• 英文别名: Ethanol, 2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]-；2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethanol
• CAS: 18790-97-1
• 化学式: C₁₂H₁₉NO₄
• 分子量: 241.287
• InChiKey: LQGLNHNBYCRXIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  73.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-[2-[2-(4-硝基苯氧基)乙氧基]乙氧基]乙醇 在 铁粉 、 氯化铵 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 6.0h， 以80%的产率得到2-[2-[2-(4-氨基苯氧基)乙氧基]乙氧基]乙醇
  参考文献：
  名称：

  靶向粘着斑激酶的化合物及制备方法和应用

  摘要：

  本发明涉及一种靶向粘着斑激酶的化合物及制备方法和应用。本发明的靶向粘着斑激酶的化合物具有以下通式：本发明的靶向粘着斑激酶的化合物结构简单其可以作为标记前体的应用，优选作为放射性标记前体的应用。本发明的靶向粘着斑激酶的化合物还具有在靶向粘着斑激酶中的应用或在制备肿瘤治疗药物中的用途或在制备肿瘤诊断显像剂中的用途，具有良好的应用效果。

  公开号：

  CN114716385A

文献信息

• Process of making 3-phenylimino-3h-phenothiazine or 3-phenylimino-3h-phenoxazine mediator
  申请人：Marfurt Karen L.

  公开号：US20090171081A1

  公开（公告）日：2009-07-02

  A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.

  一种制备3-苯基亚胺基-3H-苯并噻嗪或3-苯基亚胺基-3H-苯并噁嗪介质的方法，包括提供含有苯并噻嗪或苯并噁嗪的第一反应物，提供第一溶剂，提供第二反应物和提供第二溶剂。将第一反应物、第一溶剂、第二反应物和第二溶剂混合形成反应物溶液。将过硫酸钠加入反应物溶液中，使第一反应物和第二反应物偶联，从而得到包含3-苯基亚胺基-3H-苯并噻嗪或3-苯基亚胺基-3H-苯并噁嗪介质的反应溶液。
• HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
  申请人：An Haoyun

  公开号：US20090048271A1

  公开（公告）日：2009-02-19

  Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

  本发明揭示了具有融合的双环杂芳环系统，其中含有一个杂环五元环的杂环取代的新化合物。这些化合物可以抑制多种类型的癌细胞的生长，因此可用于治疗癌症。这些化合物的疗效是通过一种监测细胞生长/迁移的系统来证明的，该系统显示它们是癌细胞生长和/或迁移的有效抑制剂。此外，本发明的化合物已被证明能够停止体内肿瘤的生长，并减小体内肿瘤的大小。本发明还揭示了包含这些化合物的组合物以及使用这些化合物和组合物治疗癌症的方法。
• PROCESS OF MAKING 3-PHENYLIMINO-3H-PHENOTHIAZINE OR 3-PHENYLIMINO-3H-PHENOXAZINE MEDIATOR
  申请人：Bayer HealthCare LLC

  公开号：EP2229590A1

  公开（公告）日：2010-09-22
• PROCESS OF MAKING 3-PHENYLIMINO-3H-PHENOXAZINE MEDIATOR
  申请人：Marfurt Karen L.

  公开号：US20110313155A1

  公开（公告）日：2011-12-22

  A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.
• Mediator For Test Sensor
  申请人：Bayer Healthcare LLC

  公开号：US20130126350A1

  公开（公告）日：2013-05-23

  A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.